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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2011 Volume 26 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2011 Volume 26 Issue 5

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Article

Protein expression of the Ets transcription factor Elf-1 in breast cancer cells is negatively correlated with histological grading, but not with clinical outcome

  • Authors:
    • Alice Gerloff
    • Angela Dittmer
    • Ilka Oerlecke
    • Hans-Jürgen Holzhausen
    • Jürgen Dittmer

  • View Affiliations / Copyright

    Affiliations: Klinik für Gynäkologie, Universität Halle, Halle/Saale, Germany, Klinik für Gynäkologie, Universität Halle, Ernst-Grube-Str. 40, 06120 Halle/Saale, Germany
  • Pages: 1121-1125
    |
    Published online on: August 2, 2011
       https://doi.org/10.3892/or.2011.1409
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Abstract

Several members of the Ets (E26 transformation specific) transcription factor family are involved in tumor progression, e.g. by activating matrix metalloproteases. Ets proteins share a unique DNA-binding domain, the Ets domain, which specifically recognizes GGAA/T-containing sequences common in many promoters. While the roles of quite a number of Ets proteins in carcinogenesis have been well established, little is known about the importance of the Ets protein Elf-1 (E74-like factor 1) in cancer. Herein, we analyzed the expression of Elf-1 in breast cancer. We found that, like T-cells, breast cancer cells express both the 80 and 98 kDa isoforms of the Elf-1 protein with the 98 kDa isoform only be present in the nucleus. Immunohistochemical analysis of 119 breast cancer biopsies showed anti-Elf-1 immunoreactivity exclusively in the nucleus. Elf-1 expression varied largely among the breast cancer samples showing a negative correlation with histological grading. However, no association of Elf-1 expression with clinical outcome was observed, even when sub-cohorts of patients who received either only adjuvant endocrine treatment or only chemotherapy were separately analyzed. These data suggest that Elf-1 may modulate breast cancer progression to some extent without having an impact on survival of breast cancer patients.

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Copy and paste a formatted citation
Spandidos Publications style
Gerloff A, Dittmer A, Oerlecke I, Holzhausen H and Dittmer J: Protein expression of the Ets transcription factor Elf-1 in breast cancer cells is negatively correlated with histological grading, but not with clinical outcome. Oncol Rep 26: 1121-1125, 2011.
APA
Gerloff, A., Dittmer, A., Oerlecke, I., Holzhausen, H., & Dittmer, J. (2011). Protein expression of the Ets transcription factor Elf-1 in breast cancer cells is negatively correlated with histological grading, but not with clinical outcome. Oncology Reports, 26, 1121-1125. https://doi.org/10.3892/or.2011.1409
MLA
Gerloff, A., Dittmer, A., Oerlecke, I., Holzhausen, H., Dittmer, J."Protein expression of the Ets transcription factor Elf-1 in breast cancer cells is negatively correlated with histological grading, but not with clinical outcome". Oncology Reports 26.5 (2011): 1121-1125.
Chicago
Gerloff, A., Dittmer, A., Oerlecke, I., Holzhausen, H., Dittmer, J."Protein expression of the Ets transcription factor Elf-1 in breast cancer cells is negatively correlated with histological grading, but not with clinical outcome". Oncology Reports 26, no. 5 (2011): 1121-1125. https://doi.org/10.3892/or.2011.1409
Copy and paste a formatted citation
x
Spandidos Publications style
Gerloff A, Dittmer A, Oerlecke I, Holzhausen H and Dittmer J: Protein expression of the Ets transcription factor Elf-1 in breast cancer cells is negatively correlated with histological grading, but not with clinical outcome. Oncol Rep 26: 1121-1125, 2011.
APA
Gerloff, A., Dittmer, A., Oerlecke, I., Holzhausen, H., & Dittmer, J. (2011). Protein expression of the Ets transcription factor Elf-1 in breast cancer cells is negatively correlated with histological grading, but not with clinical outcome. Oncology Reports, 26, 1121-1125. https://doi.org/10.3892/or.2011.1409
MLA
Gerloff, A., Dittmer, A., Oerlecke, I., Holzhausen, H., Dittmer, J."Protein expression of the Ets transcription factor Elf-1 in breast cancer cells is negatively correlated with histological grading, but not with clinical outcome". Oncology Reports 26.5 (2011): 1121-1125.
Chicago
Gerloff, A., Dittmer, A., Oerlecke, I., Holzhausen, H., Dittmer, J."Protein expression of the Ets transcription factor Elf-1 in breast cancer cells is negatively correlated with histological grading, but not with clinical outcome". Oncology Reports 26, no. 5 (2011): 1121-1125. https://doi.org/10.3892/or.2011.1409
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