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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2011 Volume 26 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article Open Access

Serum proteome profiling of primary breast cancer indicates a specific biomarker profile

  • Authors:
    • Daniel Böhm
    • Ksenia Keller
    • Nelli Wehrwein
    • Antje Lebrecht
    • Marcus Schmidt
    • Heinz Kölbl
    • Franz-Hermann Grus

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
  • Pages: 1051-1056
    |
    Published online on: August 11, 2011
       https://doi.org/10.3892/or.2011.1420
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Abstract

Non-invasive biomarkers for early breast cancer detection are urgently needed, as the risk of recurrent morbidity and mortality is closely related to the stage of the disease at the time of primary surgery. Currently, there are no established clinical biomarkers for breast cancer. Evaluation of protein expression patterns in body fluids using proteomic technologies can be used to discover new biomarkers for the detection of breast cancer. The aim of this study was to identify a biomarker signature identifying primary non-metastatic breast cancer and healthy controls. We screened 91 serum samples including 45 breast cancer patients and 46 healthy women using a proteomic approach. We found 14 biomarkers whose combination detects breast cancer patients from non-cancer controls with a sensitivity of 89% and specificity of 67%. Five biomarkers were comparable with previously identified proteins from published data using similar approaches. This biomarker panel allows accurate discrimination between breast cancer and healthy individuals. In addition, it could distinguish subgroups of breast cancer based on patterns of several specific biomarkers. Further validation of biomarkers could potentially facilitate the early diagnosis of breast cancer as an aid to imaging diagnostics.

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Copy and paste a formatted citation
Spandidos Publications style
Böhm D, Keller K, Wehrwein N, Lebrecht A, Schmidt M, Kölbl H and Grus F: Serum proteome profiling of primary breast cancer indicates a specific biomarker profile. Oncol Rep 26: 1051-1056, 2011.
APA
Böhm, D., Keller, K., Wehrwein, N., Lebrecht, A., Schmidt, M., Kölbl, H., & Grus, F. (2011). Serum proteome profiling of primary breast cancer indicates a specific biomarker profile. Oncology Reports, 26, 1051-1056. https://doi.org/10.3892/or.2011.1420
MLA
Böhm, D., Keller, K., Wehrwein, N., Lebrecht, A., Schmidt, M., Kölbl, H., Grus, F."Serum proteome profiling of primary breast cancer indicates a specific biomarker profile". Oncology Reports 26.5 (2011): 1051-1056.
Chicago
Böhm, D., Keller, K., Wehrwein, N., Lebrecht, A., Schmidt, M., Kölbl, H., Grus, F."Serum proteome profiling of primary breast cancer indicates a specific biomarker profile". Oncology Reports 26, no. 5 (2011): 1051-1056. https://doi.org/10.3892/or.2011.1420
Copy and paste a formatted citation
x
Spandidos Publications style
Böhm D, Keller K, Wehrwein N, Lebrecht A, Schmidt M, Kölbl H and Grus F: Serum proteome profiling of primary breast cancer indicates a specific biomarker profile. Oncol Rep 26: 1051-1056, 2011.
APA
Böhm, D., Keller, K., Wehrwein, N., Lebrecht, A., Schmidt, M., Kölbl, H., & Grus, F. (2011). Serum proteome profiling of primary breast cancer indicates a specific biomarker profile. Oncology Reports, 26, 1051-1056. https://doi.org/10.3892/or.2011.1420
MLA
Böhm, D., Keller, K., Wehrwein, N., Lebrecht, A., Schmidt, M., Kölbl, H., Grus, F."Serum proteome profiling of primary breast cancer indicates a specific biomarker profile". Oncology Reports 26.5 (2011): 1051-1056.
Chicago
Böhm, D., Keller, K., Wehrwein, N., Lebrecht, A., Schmidt, M., Kölbl, H., Grus, F."Serum proteome profiling of primary breast cancer indicates a specific biomarker profile". Oncology Reports 26, no. 5 (2011): 1051-1056. https://doi.org/10.3892/or.2011.1420
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