Remarkable difference of somatic mutation patterns between oncogenes and tumor suppressor genes

  • Authors:
    • Haoxuan Liu
    • Yuhang Xing
    • Sihai Yang
    • Dacheng Tian
  • View Affiliations

  • Published online on: September 1, 2011     https://doi.org/10.3892/or.2011.1443
  • Pages: 1539-1546
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Abstract

Cancers arise owing to mutations that confer selective growth advantages on the cells in a subset of tumor suppressor and/or oncogenes. To understand oncogenesis and diagnose cancers, it is crucial to discriminate these two groups of genes by using the difference in their mutation patterns. Here, we investigated >120,000 mutation samples in 66 well-known tumor suppressor genes and oncogenes of the COSMIC database, and found a set of significant differences in mutation patterns (e.g., non-3n-indel, non-sense SNP and mutation hotspot) between them. By screening the best measurement, we developed indices to readily distinguish one from another and predict clearly the unknown oncogenesis genes as tumor suppressors (e.g., ASXL1, HNF1A and KDM6A) or oncogenes (e.g., FOXL2, MYD88 and TSHR). Based on our results, a third gene group can be classified, which has a mutational pattern between tumor suppressors and oncogenes. The concept of the third gene group could help to understand gene function in different cancers or individual patients and to know the exact function of genes in oncogenesis. In conclusion, our study provides further insights into cancer-related genes and identifies several potential therapeutic targets.

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December 2011
Volume 26 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Liu H, Xing Y, Yang S and Tian D: Remarkable difference of somatic mutation patterns between oncogenes and tumor suppressor genes. Oncol Rep 26: 1539-1546, 2011
APA
Liu, H., Xing, Y., Yang, S., & Tian, D. (2011). Remarkable difference of somatic mutation patterns between oncogenes and tumor suppressor genes. Oncology Reports, 26, 1539-1546. https://doi.org/10.3892/or.2011.1443
MLA
Liu, H., Xing, Y., Yang, S., Tian, D."Remarkable difference of somatic mutation patterns between oncogenes and tumor suppressor genes". Oncology Reports 26.6 (2011): 1539-1546.
Chicago
Liu, H., Xing, Y., Yang, S., Tian, D."Remarkable difference of somatic mutation patterns between oncogenes and tumor suppressor genes". Oncology Reports 26, no. 6 (2011): 1539-1546. https://doi.org/10.3892/or.2011.1443