Frequent loss of p19INK4D expression in hepatocellular carcinoma: relationship to tumor differentiation and patient survival

  • Authors:
    • Asahiro Morishita
    • Jian Gong
    • Akihiro Deguchi
    • Joji Tani
    • Hisaaki Miyoshi
    • Hirohito Yoshida
    • Takashi Himoto
    • Hirohito Yoneyama
    • Hirohito Mori
    • Kiyohito Kato
    • Kazutaka Kurokohchi
    • Kazushi Deguchi
    • Kunihiko Izuishi
    • Yasushi Suzuki
    • Yoshio Kushida
    • Reiji Haba
    • Hisaaki Iwama
    • Seishiro Watanabe
    • Jeanine D'Armiento
    • Tsutomu Masaki
  • View Affiliations

  • Published online on: September 7, 2011     https://doi.org/10.3892/or.2011.1452
  • Pages: 1363-1368
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Abstract

p19INK4D belongs to the family of cyclin-dependent kinase inhibitors (CdkIs) that target the cyclin-dependent kinases and inhibit their catalytic activity. The role of p19INK4D in cell cycle progression in hepatocellular carcinoma (HCC) is poorly characterized. The aim of this study was to examine the expression of p19INK4D in various liver diseases including HCC and to assess its clinical significance in HCC. We examined the expression of p19INK4D by immunohistochemistry in 81 cases of various liver diseases, including 51 HCCs. We analyzed the relationship among p19INK4D expression in HCC in combination with histopathological stage, differentiation, several histopathological factors of possible prognostic value and patient survival. Immunohistochemical analysis revealed the frequent loss of p19INK4D expression consistent with the differentiation of HCC. The loss of p19INK4D expression was shown to be associated with a poor prognosis by analyzing clinicopathological features. In conclusion, we found that loss of p19INK4D protein was frequent in HCC, especially in poorly differentiated HCC, suggesting that p19INK4D may play a role in the differentiation of HCC. Furthermore, expression of p19INK4D may be an effective predictor of clinical behavior in HCC, and therefore, a new prognostic marker for HCC.

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December 2011
Volume 26 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Morishita A, Gong J, Deguchi A, Tani J, Miyoshi H, Yoshida H, Himoto T, Yoneyama H, Mori H, Kato K, Kato K, et al: Frequent loss of p19INK4D expression in hepatocellular carcinoma: relationship to tumor differentiation and patient survival. Oncol Rep 26: 1363-1368, 2011.
APA
Morishita, A., Gong, J., Deguchi, A., Tani, J., Miyoshi, H., Yoshida, H. ... Masaki, T. (2011). Frequent loss of p19INK4D expression in hepatocellular carcinoma: relationship to tumor differentiation and patient survival. Oncology Reports, 26, 1363-1368. https://doi.org/10.3892/or.2011.1452
MLA
Morishita, A., Gong, J., Deguchi, A., Tani, J., Miyoshi, H., Yoshida, H., Himoto, T., Yoneyama, H., Mori, H., Kato, K., Kurokohchi, K., Deguchi, K., Izuishi, K., Suzuki, Y., Kushida, Y., Haba, R., Iwama, H., Watanabe, S., D'Armiento, J., Masaki, T."Frequent loss of p19INK4D expression in hepatocellular carcinoma: relationship to tumor differentiation and patient survival". Oncology Reports 26.6 (2011): 1363-1368.
Chicago
Morishita, A., Gong, J., Deguchi, A., Tani, J., Miyoshi, H., Yoshida, H., Himoto, T., Yoneyama, H., Mori, H., Kato, K., Kurokohchi, K., Deguchi, K., Izuishi, K., Suzuki, Y., Kushida, Y., Haba, R., Iwama, H., Watanabe, S., D'Armiento, J., Masaki, T."Frequent loss of p19INK4D expression in hepatocellular carcinoma: relationship to tumor differentiation and patient survival". Oncology Reports 26, no. 6 (2011): 1363-1368. https://doi.org/10.3892/or.2011.1452