Role of autophagy in resistance to oxaliplatin in hepatocellular carcinoma cells

  • Authors:
    • Hailei Du
    • Weiping Yang
    • Lin Chen
    • Mingming Shi
    • Varun Seewoo
    • Jiayu Wang
    • Andy Lin
    • Zhuoran Liu
    • Weihua Qiu
  • View Affiliations

  • Published online on: September 20, 2011     https://doi.org/10.3892/or.2011.1464
  • Pages: 143-150
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Abstract

In spite of an initially promising anti-tumor activity, oxaliplatin-based combinatorial treatments can eventually result in a tumor resistance response. In this study we aimed to understand the role of autophagy in HCC cell resistance to oxaliplatin and to discuss its potential therapeutic implication. We found that exposure to oxaliplatin induced a significant increase in LC3 lipidation and subsequent LC3 puncta formation. While the proliferation of HCC cells was inhibited upon oxaliplatin exposure, inhibition of autophagy by ATG7 interference and chloroquine pre-treatment further increased the sensitivity to chemotherapy. Meanwhile, the oxaliplatin-induced apoptotic cell death was significantly enhanced. These results suggest that autophagy may function importantly in HepG2 cell resistance to oxaliplatin. Intriguingly, the resistance could be recovered apparently by inhibition of autophagy. This also points to the potential therapy for hepatoma by perturbing autophagy.

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January 2012
Volume 27 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Du H, Yang W, Chen L, Shi M, Seewoo V, Wang J, Lin A, Liu Z and Qiu W: Role of autophagy in resistance to oxaliplatin in hepatocellular carcinoma cells. Oncol Rep 27: 143-150, 2012.
APA
Du, H., Yang, W., Chen, L., Shi, M., Seewoo, V., Wang, J. ... Qiu, W. (2012). Role of autophagy in resistance to oxaliplatin in hepatocellular carcinoma cells. Oncology Reports, 27, 143-150. https://doi.org/10.3892/or.2011.1464
MLA
Du, H., Yang, W., Chen, L., Shi, M., Seewoo, V., Wang, J., Lin, A., Liu, Z., Qiu, W."Role of autophagy in resistance to oxaliplatin in hepatocellular carcinoma cells". Oncology Reports 27.1 (2012): 143-150.
Chicago
Du, H., Yang, W., Chen, L., Shi, M., Seewoo, V., Wang, J., Lin, A., Liu, Z., Qiu, W."Role of autophagy in resistance to oxaliplatin in hepatocellular carcinoma cells". Oncology Reports 27, no. 1 (2012): 143-150. https://doi.org/10.3892/or.2011.1464