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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2012 Volume 27 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Bag3 promotes resistance to apoptosis through Bcl-2 family members in non-small cell lung cancer

  • Authors:
    • Yong Zhang
    • Jian-Hua Wang
    • Qiang Lu
    • Yun-Jie Wang

  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, P.R. China
  • Pages: 109-113
    |
    Published online on: October 3, 2011
       https://doi.org/10.3892/or.2011.1486
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Abstract

In non-small cell lung cancer (NSCLC) certain molecular characteristics, which are related to molecular alterations have been investigated. These are responsible for both the initiation and maintenance of the malignancy in lung cancer. The aim of this study was to evaluate the influence of Bag3 (Bcl-2 associated athanogene 3) in the regulation of apoptosis on NSCLC. Bag3 and Hsp70 expression were examined by immunohistochemistry to confirm their potential roles in the prevalence of NSCLC. We also established human normal bronchial epithelial cells and HOP-62 cell line as the model to analyze cell apoptosis and the expression of Hsp70, Bcl-XL and Bcl-2, which were affected by Bag3. In this study, we found that Bag3 and Hsp70 are highly expressed in few tissues and cell lines of NSCLC. Bag3 inhibits apoptosis in human normal bronchial epithelial cell lines and sustain the survival of NSCLC cells. Bag3, Hsp70, Bcl-XL and Bcl-2 are up-regulated in NSCLC cell lines. At the same time, the silencing of Bag3 results in diminishing protein levels of Bcl-XL and Bcl-2. The results of immunoprecipitation identified that Bag3 could interact with Hsp70, Bcl-XL and Bcl-2 NSCLC cells directly or indirectly. We conclude that NSCLC cells were protected from apoptosis through increasing Bag3 expression and consequently promoted the expression of Bcl-XL and Bcl-2.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Wang J, Lu Q and Wang Y: Bag3 promotes resistance to apoptosis through Bcl-2 family members in non-small cell lung cancer. Oncol Rep 27: 109-113, 2012.
APA
Zhang, Y., Wang, J., Lu, Q., & Wang, Y. (2012). Bag3 promotes resistance to apoptosis through Bcl-2 family members in non-small cell lung cancer. Oncology Reports, 27, 109-113. https://doi.org/10.3892/or.2011.1486
MLA
Zhang, Y., Wang, J., Lu, Q., Wang, Y."Bag3 promotes resistance to apoptosis through Bcl-2 family members in non-small cell lung cancer". Oncology Reports 27.1 (2012): 109-113.
Chicago
Zhang, Y., Wang, J., Lu, Q., Wang, Y."Bag3 promotes resistance to apoptosis through Bcl-2 family members in non-small cell lung cancer". Oncology Reports 27, no. 1 (2012): 109-113. https://doi.org/10.3892/or.2011.1486
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Wang J, Lu Q and Wang Y: Bag3 promotes resistance to apoptosis through Bcl-2 family members in non-small cell lung cancer. Oncol Rep 27: 109-113, 2012.
APA
Zhang, Y., Wang, J., Lu, Q., & Wang, Y. (2012). Bag3 promotes resistance to apoptosis through Bcl-2 family members in non-small cell lung cancer. Oncology Reports, 27, 109-113. https://doi.org/10.3892/or.2011.1486
MLA
Zhang, Y., Wang, J., Lu, Q., Wang, Y."Bag3 promotes resistance to apoptosis through Bcl-2 family members in non-small cell lung cancer". Oncology Reports 27.1 (2012): 109-113.
Chicago
Zhang, Y., Wang, J., Lu, Q., Wang, Y."Bag3 promotes resistance to apoptosis through Bcl-2 family members in non-small cell lung cancer". Oncology Reports 27, no. 1 (2012): 109-113. https://doi.org/10.3892/or.2011.1486
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