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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2012 Volume 27 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article Open Access

The histone deacetylase inhibitor trichostatin A alters microRNA expression profiles in apoptosis-resistant breast cancer cells

  • Authors:
    • Lyndsay V. Rhodes
    • Ashley M. Nitschke
    • H. Chris Segar
    • Elizabeth C. Martin
    • Jennifer L. Driver
    • Steven Elliott
    • Seung Yoon Nam
    • Meng Li
    • Kenneth P. Nephew
    • Matthew E. Burow
    • Bridgette M. Collins-Burow

  • View Affiliations / Copyright

    Affiliations: Department of Medicine, Section of Hematology and Medical Oncology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA, Tulane University Health Sciences Center, Department of Medicine, 1430 Tulane Ave. SL-78, New Orleans, LA 70112, USA
  • Pages: 10-16
    |
    Published online on: October 4, 2011
       https://doi.org/10.3892/or.2011.1488
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Abstract

The development of drug resistance represents a major complication in the effective treatment of breast cancer. Epigenetic therapy, through the use of histone deacetylase inhibitors (HDACi) or demethylation agents, is an emerging area of therapeutic targeting in a number of ontological entities, particularly in the setting of aggressive therapy-resistant disease. Using the well-described HDAC inhibitor trichostatin A (TSA) we demonstrate the suppression of in vitro clonogenicity in the previously described apoptosis-resistant MCF-7TN-R breast carcinoma cell line. Additionally, recent work has demonstrated that these agents can alter the expression profile of microRNA signatures in malignant cells. Using an unbiased microRNA microarray analysis, changes in miRNA expression of MCF-7TN-R cells treated with TSA for 24 h were analyzed. We observed significant up-regulation of 22 miRNAs and down-regulation of 10 miRNAs in response to TSA treatment. Our results demonstrate that the HDACi, TSA, exerts anticancer activity in the apoptosis-resistant MCF-7TN-R breast carcinoma cell line. This activity is correlated with TSA alteration of microRNA expression profiles indicative of a less aggressive phenotype.

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Copy and paste a formatted citation
Spandidos Publications style
Rhodes LV, Nitschke AM, Segar HC, Martin EC, Driver JL, Elliott S, Nam SY, Li M, Nephew KP, Burow ME, Burow ME, et al: The histone deacetylase inhibitor trichostatin A alters microRNA expression profiles in apoptosis-resistant breast cancer cells. Oncol Rep 27: 10-16, 2012.
APA
Rhodes, L.V., Nitschke, A.M., Segar, H.C., Martin, E.C., Driver, J.L., Elliott, S. ... Collins-Burow, B.M. (2012). The histone deacetylase inhibitor trichostatin A alters microRNA expression profiles in apoptosis-resistant breast cancer cells. Oncology Reports, 27, 10-16. https://doi.org/10.3892/or.2011.1488
MLA
Rhodes, L. V., Nitschke, A. M., Segar, H. C., Martin, E. C., Driver, J. L., Elliott, S., Nam, S. Y., Li, M., Nephew, K. P., Burow, M. E., Collins-Burow, B. M."The histone deacetylase inhibitor trichostatin A alters microRNA expression profiles in apoptosis-resistant breast cancer cells". Oncology Reports 27.1 (2012): 10-16.
Chicago
Rhodes, L. V., Nitschke, A. M., Segar, H. C., Martin, E. C., Driver, J. L., Elliott, S., Nam, S. Y., Li, M., Nephew, K. P., Burow, M. E., Collins-Burow, B. M."The histone deacetylase inhibitor trichostatin A alters microRNA expression profiles in apoptosis-resistant breast cancer cells". Oncology Reports 27, no. 1 (2012): 10-16. https://doi.org/10.3892/or.2011.1488
Copy and paste a formatted citation
x
Spandidos Publications style
Rhodes LV, Nitschke AM, Segar HC, Martin EC, Driver JL, Elliott S, Nam SY, Li M, Nephew KP, Burow ME, Burow ME, et al: The histone deacetylase inhibitor trichostatin A alters microRNA expression profiles in apoptosis-resistant breast cancer cells. Oncol Rep 27: 10-16, 2012.
APA
Rhodes, L.V., Nitschke, A.M., Segar, H.C., Martin, E.C., Driver, J.L., Elliott, S. ... Collins-Burow, B.M. (2012). The histone deacetylase inhibitor trichostatin A alters microRNA expression profiles in apoptosis-resistant breast cancer cells. Oncology Reports, 27, 10-16. https://doi.org/10.3892/or.2011.1488
MLA
Rhodes, L. V., Nitschke, A. M., Segar, H. C., Martin, E. C., Driver, J. L., Elliott, S., Nam, S. Y., Li, M., Nephew, K. P., Burow, M. E., Collins-Burow, B. M."The histone deacetylase inhibitor trichostatin A alters microRNA expression profiles in apoptosis-resistant breast cancer cells". Oncology Reports 27.1 (2012): 10-16.
Chicago
Rhodes, L. V., Nitschke, A. M., Segar, H. C., Martin, E. C., Driver, J. L., Elliott, S., Nam, S. Y., Li, M., Nephew, K. P., Burow, M. E., Collins-Burow, B. M."The histone deacetylase inhibitor trichostatin A alters microRNA expression profiles in apoptosis-resistant breast cancer cells". Oncology Reports 27, no. 1 (2012): 10-16. https://doi.org/10.3892/or.2011.1488
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