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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2012 Volume 27 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

p53 codon 72 polymorphisms and random amplified polymorphic DNA analysis of non-melanoma skin cancer through archival formalin-fixed paraffin-embedded tissue

  • Authors:
    • Cheah Yoke-Kqueen
    • Nurul-Syakima Ab Mutalib
    • Shiran Mohd Sidik
    • Lee Learn-Han
    • Tan Geok-Chin

  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia
  • Pages: 753-763
    |
    Published online on: December 6, 2011
       https://doi.org/10.3892/or.2011.1581
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Abstract

Non-melanoma skin cancer (NMSC) is classified among the ten most frequent cancers in Malaysia. A common polymorphism at codon 72 of the p53 tumor suppressor gene and its influence on cancer risk has been studied for different types of cancer with mixed and inconsistent results with limited published data on the Malaysian population so far. In the present study, the frequency of p53 codon 72 polymorphism in 60 patients with NMSC was investigated from archival formalin-fixed paraffin-embedded (FFPE) tissue obtained from Hospital Universiti Kebangsaan Malaysia (HUKM). Additionally, random amplified polymorhic DNA -polymorphic chain reaction (RAPD-PCR) was employed for preliminary biomarker development. NMSC FFPE samples (70%) possess Arg/Arg, 20% with Pro/Pro and 10% with Arg/Pro. In total, there was no significant difference in the p53 codon 72 genotypes between histological types of NMSC, gender, race, tumor location and age group. However, there was an apparent age-associated increase in the Arg/Arg genotype but did not reach statistical significance (P=0.235). NMSC types and demographic characteristics did not influence genotype distribution. On the other hand, BCC and SCC distributions are influenced by age group, race and tumor location.

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Copy and paste a formatted citation
Spandidos Publications style
Yoke-Kqueen C, Ab Mutalib N, Sidik SM, Learn-Han L and Geok-Chin T: p53 codon 72 polymorphisms and random amplified polymorphic DNA analysis of non-melanoma skin cancer through archival formalin-fixed paraffin-embedded tissue. Oncol Rep 27: 753-763, 2012.
APA
Yoke-Kqueen, C., Ab Mutalib, N., Sidik, S.M., Learn-Han, L., & Geok-Chin, T. (2012). p53 codon 72 polymorphisms and random amplified polymorphic DNA analysis of non-melanoma skin cancer through archival formalin-fixed paraffin-embedded tissue. Oncology Reports, 27, 753-763. https://doi.org/10.3892/or.2011.1581
MLA
Yoke-Kqueen, C., Ab Mutalib, N., Sidik, S. M., Learn-Han, L., Geok-Chin, T."p53 codon 72 polymorphisms and random amplified polymorphic DNA analysis of non-melanoma skin cancer through archival formalin-fixed paraffin-embedded tissue". Oncology Reports 27.3 (2012): 753-763.
Chicago
Yoke-Kqueen, C., Ab Mutalib, N., Sidik, S. M., Learn-Han, L., Geok-Chin, T."p53 codon 72 polymorphisms and random amplified polymorphic DNA analysis of non-melanoma skin cancer through archival formalin-fixed paraffin-embedded tissue". Oncology Reports 27, no. 3 (2012): 753-763. https://doi.org/10.3892/or.2011.1581
Copy and paste a formatted citation
x
Spandidos Publications style
Yoke-Kqueen C, Ab Mutalib N, Sidik SM, Learn-Han L and Geok-Chin T: p53 codon 72 polymorphisms and random amplified polymorphic DNA analysis of non-melanoma skin cancer through archival formalin-fixed paraffin-embedded tissue. Oncol Rep 27: 753-763, 2012.
APA
Yoke-Kqueen, C., Ab Mutalib, N., Sidik, S.M., Learn-Han, L., & Geok-Chin, T. (2012). p53 codon 72 polymorphisms and random amplified polymorphic DNA analysis of non-melanoma skin cancer through archival formalin-fixed paraffin-embedded tissue. Oncology Reports, 27, 753-763. https://doi.org/10.3892/or.2011.1581
MLA
Yoke-Kqueen, C., Ab Mutalib, N., Sidik, S. M., Learn-Han, L., Geok-Chin, T."p53 codon 72 polymorphisms and random amplified polymorphic DNA analysis of non-melanoma skin cancer through archival formalin-fixed paraffin-embedded tissue". Oncology Reports 27.3 (2012): 753-763.
Chicago
Yoke-Kqueen, C., Ab Mutalib, N., Sidik, S. M., Learn-Han, L., Geok-Chin, T."p53 codon 72 polymorphisms and random amplified polymorphic DNA analysis of non-melanoma skin cancer through archival formalin-fixed paraffin-embedded tissue". Oncology Reports 27, no. 3 (2012): 753-763. https://doi.org/10.3892/or.2011.1581
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