Cytogenetic and molecular cytogenetic findings in giant dedifferentiated liposarcoma of the thigh

  • Authors:
    • Jun Nishio
    • Mikiko Aoki
    • Kazuki Nabeshima
    • Hiroshi Iwasaki
    • Masatoshi Naito
  • View Affiliations

  • Published online on: December 7, 2011     https://doi.org/10.3892/or.2011.1584
  • Pages: 764-768
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Abstract

Non-retroperitoneal dedifferentiated liposarcoma (DDLS) is relatively uncommon and its characterization at the molecular genetic level has been limited. We describe the cyto­genetic and molecular cytogenetic findings of giant DDLS arising in the right thigh of an 83-year-old woman. Magnetic resonance imaging revealed a mass composed of two components with heterogeneous signal intensities, suggesting the coexistence of a fatty area and another soft tissue component. A wide resection of the tumor was performed. The resected, grossly hetero­geneous mass, measuring 26x18x8 cm, was histopathologically composed of a well-differentiated liposarcomatous component transitioning abruptly into a dedifferentiated one. Cytogenetic analysis exhibited a complex karyotype with several numerical and structural alterations, including ring and giant marker chromosomes. Metaphase-based comparative genomic hybridi­zation analysis showed high-level amplifications of 1q21-q25 and 12q13-q21. Interphase fluorescence in situ hybridization analysis revealed MDM2 and CDK4 gene amplification in both the well-differentiated and dedifferentiated components. These findings indicate that DDLS of the extremity shares a similar genetic background to retroperitoneal DDLS.

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March 2012
Volume 27 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Nishio J, Aoki M, Nabeshima K, Iwasaki H and Naito M: Cytogenetic and molecular cytogenetic findings in giant dedifferentiated liposarcoma of the thigh. Oncol Rep 27: 764-768, 2012.
APA
Nishio, J., Aoki, M., Nabeshima, K., Iwasaki, H., & Naito, M. (2012). Cytogenetic and molecular cytogenetic findings in giant dedifferentiated liposarcoma of the thigh. Oncology Reports, 27, 764-768. https://doi.org/10.3892/or.2011.1584
MLA
Nishio, J., Aoki, M., Nabeshima, K., Iwasaki, H., Naito, M."Cytogenetic and molecular cytogenetic findings in giant dedifferentiated liposarcoma of the thigh". Oncology Reports 27.3 (2012): 764-768.
Chicago
Nishio, J., Aoki, M., Nabeshima, K., Iwasaki, H., Naito, M."Cytogenetic and molecular cytogenetic findings in giant dedifferentiated liposarcoma of the thigh". Oncology Reports 27, no. 3 (2012): 764-768. https://doi.org/10.3892/or.2011.1584