Chemoembolization of unresectable hepatocellular carcinoma: Decreased toxicity with slow-release doxorubicin‑eluting beads compared with lipiodol

  • Authors:
    • Francesco Recchia
    • Giovanni Passalacqua
    • Pietro Filauri
    • Marco Doddi
    • Pietro Boscarato
    • Giampiero Candeloro
    • Stefano Necozione
    • Giovambattista Desideri
    • Silvio Rea
  • View Affiliations

  • Published online on: January 25, 2012     https://doi.org/10.3892/or.2012.1651
  • Pages: 1377-1383
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Abstract

Chemoembolization with lipiodol (TACE) improves survival of selected patients with unresectable hepatocellular carcinoma (HCC), but results in substantial toxicity. To improve treatment tolerance, we conducted this phase II study using doxorubicin-loaded beads (DC Beads®) delivered by selective transcatheter arterial chemoembolization (DEB-TACE). We compared the results with those obtained with TACE in our historical controls. Thirty-five patients were recruited with diagnoses of HCC. Patients received DEB-TACE with doxorubicin loaded on DC Beads. Computed tomography of the upper abdomen was performed one month after DEB-TACE. Historical controls were a group of 70 patients with matched characteristics treated with TACE. After a median follow-up of 14.1 months (range, 6-36 months), 22 patients (63%) had an objective response. There was a statistically significant decrease in liver enzymes (p<0.001), lactate dehydrogenase, (p<0.001) in DEB-TACE-treated patients compared to TACE-treated patients. DEB-TACE with doxorubicin-loaded DC Beads, a safe and reliable treatment for HCC, leads to decreased toxicity compared to TACE.

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May 2012
Volume 27 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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APA
Recchia, F., Passalacqua, G., Filauri, P., Doddi, M., Boscarato, P., Candeloro, G. ... Rea, S. (2012). Chemoembolization of unresectable hepatocellular carcinoma: Decreased toxicity with slow-release doxorubicin‑eluting beads compared with lipiodol. Oncology Reports, 27, 1377-1383. https://doi.org/10.3892/or.2012.1651
MLA
Recchia, F., Passalacqua, G., Filauri, P., Doddi, M., Boscarato, P., Candeloro, G., Necozione, S., Desideri, G., Rea, S."Chemoembolization of unresectable hepatocellular carcinoma: Decreased toxicity with slow-release doxorubicin‑eluting beads compared with lipiodol". Oncology Reports 27.5 (2012): 1377-1383.
Chicago
Recchia, F., Passalacqua, G., Filauri, P., Doddi, M., Boscarato, P., Candeloro, G., Necozione, S., Desideri, G., Rea, S."Chemoembolization of unresectable hepatocellular carcinoma: Decreased toxicity with slow-release doxorubicin‑eluting beads compared with lipiodol". Oncology Reports 27, no. 5 (2012): 1377-1383. https://doi.org/10.3892/or.2012.1651