Mechanisms involved in biological behavior changes associated with Angptl4 expression in colon cancer cell lines

  • Authors:
    • Xue-Feng Huang
    • Jie Han
    • Xiao-Tong Hu
    • Chao He
  • View Affiliations

  • Published online on: February 3, 2012     https://doi.org/10.3892/or.2012.1672
  • Pages: 1541-1547
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Abstract

Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths throughout the world. Angiopoietin-like-4 (Angptl4), a member of the angiopoietin family of secreted proteins, is frequently expressed in the perinecrotic areas of different human tumors, yet its role is still unclear in colorectal cancer. Angptl4 mRNA expression in primary colorectal cancer tissue and seven colon cancer cell lines was measured by semi-quantitative RT-PCR; the influence of Angptl4 expression on the colon cancer cell lines was investigated by either overexpression or knockdown of Angptl4 in colon cancer cell lines HCT116 and HT29, respectively. The results showed that Angptl4 mRNA is frequently expressed in human colorectal cancer tissues and cell lines. Overexpression of Angptl4 promoted cell migration, F-actin reorganization and formation of pseudopodia. Further investigation showed that high Angptl4 expression was associated with an increase in ezrin/radixin/moesin and vasodilator-stimulated phosphoprotein expression and a decrease in E-cadherin expression. These results indicate that overexpression of Angptl4 may promote invasion and metastasis in CRC.

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May 2012
Volume 27 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Huang X, Han J, Hu X and He C: Mechanisms involved in biological behavior changes associated with Angptl4 expression in colon cancer cell lines. Oncol Rep 27: 1541-1547, 2012
APA
Huang, X., Han, J., Hu, X., & He, C. (2012). Mechanisms involved in biological behavior changes associated with Angptl4 expression in colon cancer cell lines. Oncology Reports, 27, 1541-1547. https://doi.org/10.3892/or.2012.1672
MLA
Huang, X., Han, J., Hu, X., He, C."Mechanisms involved in biological behavior changes associated with Angptl4 expression in colon cancer cell lines". Oncology Reports 27.5 (2012): 1541-1547.
Chicago
Huang, X., Han, J., Hu, X., He, C."Mechanisms involved in biological behavior changes associated with Angptl4 expression in colon cancer cell lines". Oncology Reports 27, no. 5 (2012): 1541-1547. https://doi.org/10.3892/or.2012.1672