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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2012 Volume 27 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Mechanisms involved in biological behavior changes associated with Angptl4 expression in colon cancer cell lines

  • Authors:
    • Xue-Feng Huang
    • Jie Han
    • Xiao-Tong Hu
    • Chao He

  • View Affiliations / Copyright

    Affiliations: Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China, Biomedical Research Center, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China
  • Pages: 1541-1547
    |
    Published online on: February 3, 2012
       https://doi.org/10.3892/or.2012.1672
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Abstract

Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths throughout the world. Angiopoietin-like-4 (Angptl4), a member of the angiopoietin family of secreted proteins, is frequently expressed in the perinecrotic areas of different human tumors, yet its role is still unclear in colorectal cancer. Angptl4 mRNA expression in primary colorectal cancer tissue and seven colon cancer cell lines was measured by semi-quantitative RT-PCR; the influence of Angptl4 expression on the colon cancer cell lines was investigated by either overexpression or knockdown of Angptl4 in colon cancer cell lines HCT116 and HT29, respectively. The results showed that Angptl4 mRNA is frequently expressed in human colorectal cancer tissues and cell lines. Overexpression of Angptl4 promoted cell migration, F-actin reorganization and formation of pseudopodia. Further investigation showed that high Angptl4 expression was associated with an increase in ezrin/radixin/moesin and vasodilator-stimulated phosphoprotein expression and a decrease in E-cadherin expression. These results indicate that overexpression of Angptl4 may promote invasion and metastasis in CRC.

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Copy and paste a formatted citation
Spandidos Publications style
Huang X, Han J, Hu X and He C: Mechanisms involved in biological behavior changes associated with Angptl4 expression in colon cancer cell lines. Oncol Rep 27: 1541-1547, 2012.
APA
Huang, X., Han, J., Hu, X., & He, C. (2012). Mechanisms involved in biological behavior changes associated with Angptl4 expression in colon cancer cell lines. Oncology Reports, 27, 1541-1547. https://doi.org/10.3892/or.2012.1672
MLA
Huang, X., Han, J., Hu, X., He, C."Mechanisms involved in biological behavior changes associated with Angptl4 expression in colon cancer cell lines". Oncology Reports 27.5 (2012): 1541-1547.
Chicago
Huang, X., Han, J., Hu, X., He, C."Mechanisms involved in biological behavior changes associated with Angptl4 expression in colon cancer cell lines". Oncology Reports 27, no. 5 (2012): 1541-1547. https://doi.org/10.3892/or.2012.1672
Copy and paste a formatted citation
x
Spandidos Publications style
Huang X, Han J, Hu X and He C: Mechanisms involved in biological behavior changes associated with Angptl4 expression in colon cancer cell lines. Oncol Rep 27: 1541-1547, 2012.
APA
Huang, X., Han, J., Hu, X., & He, C. (2012). Mechanisms involved in biological behavior changes associated with Angptl4 expression in colon cancer cell lines. Oncology Reports, 27, 1541-1547. https://doi.org/10.3892/or.2012.1672
MLA
Huang, X., Han, J., Hu, X., He, C."Mechanisms involved in biological behavior changes associated with Angptl4 expression in colon cancer cell lines". Oncology Reports 27.5 (2012): 1541-1547.
Chicago
Huang, X., Han, J., Hu, X., He, C."Mechanisms involved in biological behavior changes associated with Angptl4 expression in colon cancer cell lines". Oncology Reports 27, no. 5 (2012): 1541-1547. https://doi.org/10.3892/or.2012.1672
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