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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2012 Volume 27 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

CRTC1-MAML2 gene fusion in mucoepidermoid carcinoma of the lacrimal gland

  • Authors:
    • Sarah Linéa Von Holstein
    • André Fehr
    • Steffen Heegaard
    • Marianne Hamilton Therkildsen
    • Göran Stenman

  • View Affiliations / Copyright

    Affiliations: Institute of Neuroscience and Pharmacology, Eye Pathology Section, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, Department of Pathology, Sahlgrenska Cancer Center, University of Gothenburg, Gothenburg, Sweden, Department of Pathology, Rigshospitalet, Copenhagen, Denmark
  • Pages: 1413-1416
    |
    Published online on: February 6, 2012
       https://doi.org/10.3892/or.2012.1676
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Abstract

Epithelial tumors of the lacrimal gland are histologically similar to salivary gland tumors. Here we report on a rare case of mucoepidermoid carcinoma (MEC) in a 73‑year-old man with a swelling of the left lacrimal gland. The tumor had a microscopic appearance consistent with a classical low-grade MEC of the lacrimal gland. There were no signs of recurrence or metastases during a five-year follow-up. Using RT-PCR and FISH we demonstrated that the tumor was positive for the CRTC1-MAML2 gene fusion previously shown to be associated with in particular low-grade salivary MECs with favorable prognosis. By immunohistochemistry we showed that the majority of tumor cells, including epidermoid, intermediate and mucous producing cells, expressed the CRTC1-MAML2 fusion protein. In contrast, 15 non-MEC lacrimal neoplasm were fusion-negative. Our findings show that lacrimal MEC is not only clinically and morphologically but also genetically identical to MECs originating from other exocrine glands, including those of the lung, thyroid, cervix and salivary glands. Taken together, the present and previous studies further emphasize the fundamental biologic and genetic similarities among MECs developing from different anatomical sites and organs. Moreover, our findings indicate that the CRTC1-MAML2 fusion may be a useful diagnostic and prognostic biomarker for lacrimal MEC.

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Copy and paste a formatted citation
Spandidos Publications style
Von Holstein SL, Fehr A, Heegaard S, Therkildsen MH and Stenman G: CRTC1-MAML2 gene fusion in mucoepidermoid carcinoma of the lacrimal gland. Oncol Rep 27: 1413-1416, 2012.
APA
Von Holstein, S.L., Fehr, A., Heegaard, S., Therkildsen, M.H., & Stenman, G. (2012). CRTC1-MAML2 gene fusion in mucoepidermoid carcinoma of the lacrimal gland. Oncology Reports, 27, 1413-1416. https://doi.org/10.3892/or.2012.1676
MLA
Von Holstein, S. L., Fehr, A., Heegaard, S., Therkildsen, M. H., Stenman, G."CRTC1-MAML2 gene fusion in mucoepidermoid carcinoma of the lacrimal gland". Oncology Reports 27.5 (2012): 1413-1416.
Chicago
Von Holstein, S. L., Fehr, A., Heegaard, S., Therkildsen, M. H., Stenman, G."CRTC1-MAML2 gene fusion in mucoepidermoid carcinoma of the lacrimal gland". Oncology Reports 27, no. 5 (2012): 1413-1416. https://doi.org/10.3892/or.2012.1676
Copy and paste a formatted citation
x
Spandidos Publications style
Von Holstein SL, Fehr A, Heegaard S, Therkildsen MH and Stenman G: CRTC1-MAML2 gene fusion in mucoepidermoid carcinoma of the lacrimal gland. Oncol Rep 27: 1413-1416, 2012.
APA
Von Holstein, S.L., Fehr, A., Heegaard, S., Therkildsen, M.H., & Stenman, G. (2012). CRTC1-MAML2 gene fusion in mucoepidermoid carcinoma of the lacrimal gland. Oncology Reports, 27, 1413-1416. https://doi.org/10.3892/or.2012.1676
MLA
Von Holstein, S. L., Fehr, A., Heegaard, S., Therkildsen, M. H., Stenman, G."CRTC1-MAML2 gene fusion in mucoepidermoid carcinoma of the lacrimal gland". Oncology Reports 27.5 (2012): 1413-1416.
Chicago
Von Holstein, S. L., Fehr, A., Heegaard, S., Therkildsen, M. H., Stenman, G."CRTC1-MAML2 gene fusion in mucoepidermoid carcinoma of the lacrimal gland". Oncology Reports 27, no. 5 (2012): 1413-1416. https://doi.org/10.3892/or.2012.1676
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