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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2012 Volume 27 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article Open Access

Crotoxin enhances the antitumor activity of gefinitib (Iressa) in SK-MES-1 human lung squamous carcinoma cells

  • Authors:
    • Jun-Hua Wang
    • Yan Xie
    • Jun-Chao Wu
    • Rong Han
    • Paul F. Reid
    • Zheng-Hong Qin
    • Jing-Kang He

  • View Affiliations / Copyright

    Affiliations: Department of Cardiothoracic Surgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, P.R. China, Department of Pharmacology and Laboratory of Aging and Nervous Diseases, School of Pharmaceutical Science, Soochow University, Suzhou 215123, P.R. China, Celtic Biotech, Ltd., Dublin, Ireland
  • Pages: 1341-1347
    |
    Published online on: February 6, 2012
       https://doi.org/10.3892/or.2012.1677
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Abstract

Crotoxin (CrTX), a neurotoxin, is isolated from the venom of South American rattlesnakes and has potent antitumor activity. Here, we investigated the antitumor effect of CrTX on the SK-MES-1 human lung squamous cell carcinoma cell line that has acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors. CrTX caused G1 arrest and p-JNK protein upregulation that resulted in apoptosis of SK-MES-1 cells. SP600125, a specific inhibitor of p-JNK, could rescue SK-MES-1 cells from CrTX-induced apoptosis. CrTX and gefinitib (Iressa) both inhibited the viability and proliferation of SK-MES-1 cells in a dose- and time-dependent manner. The combination of CrTX and Iressa significantly enhanced the antitumor activity of Iressa. In vivo studies revealed that CrTX caused increased damage to blood vessels and reduced tumor size when combined with Iressa. The present study showed that the JNK signal transduction pathway mediated the anti-apoptotic effect of CrTX, and furthermore, CrTX could enhance the antitumor effect of tyrosine kinase inhibitors in cells with acquired resistance.

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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Xie Y, Wu J, Han R, Reid PF, Qin Z and He J: Crotoxin enhances the antitumor activity of gefinitib (Iressa) in SK-MES-1 human lung squamous carcinoma cells. Oncol Rep 27: 1341-1347, 2012.
APA
Wang, J., Xie, Y., Wu, J., Han, R., Reid, P.F., Qin, Z., & He, J. (2012). Crotoxin enhances the antitumor activity of gefinitib (Iressa) in SK-MES-1 human lung squamous carcinoma cells. Oncology Reports, 27, 1341-1347. https://doi.org/10.3892/or.2012.1677
MLA
Wang, J., Xie, Y., Wu, J., Han, R., Reid, P. F., Qin, Z., He, J."Crotoxin enhances the antitumor activity of gefinitib (Iressa) in SK-MES-1 human lung squamous carcinoma cells". Oncology Reports 27.5 (2012): 1341-1347.
Chicago
Wang, J., Xie, Y., Wu, J., Han, R., Reid, P. F., Qin, Z., He, J."Crotoxin enhances the antitumor activity of gefinitib (Iressa) in SK-MES-1 human lung squamous carcinoma cells". Oncology Reports 27, no. 5 (2012): 1341-1347. https://doi.org/10.3892/or.2012.1677
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Xie Y, Wu J, Han R, Reid PF, Qin Z and He J: Crotoxin enhances the antitumor activity of gefinitib (Iressa) in SK-MES-1 human lung squamous carcinoma cells. Oncol Rep 27: 1341-1347, 2012.
APA
Wang, J., Xie, Y., Wu, J., Han, R., Reid, P.F., Qin, Z., & He, J. (2012). Crotoxin enhances the antitumor activity of gefinitib (Iressa) in SK-MES-1 human lung squamous carcinoma cells. Oncology Reports, 27, 1341-1347. https://doi.org/10.3892/or.2012.1677
MLA
Wang, J., Xie, Y., Wu, J., Han, R., Reid, P. F., Qin, Z., He, J."Crotoxin enhances the antitumor activity of gefinitib (Iressa) in SK-MES-1 human lung squamous carcinoma cells". Oncology Reports 27.5 (2012): 1341-1347.
Chicago
Wang, J., Xie, Y., Wu, J., Han, R., Reid, P. F., Qin, Z., He, J."Crotoxin enhances the antitumor activity of gefinitib (Iressa) in SK-MES-1 human lung squamous carcinoma cells". Oncology Reports 27, no. 5 (2012): 1341-1347. https://doi.org/10.3892/or.2012.1677
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