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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2012 Volume 27 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

High-resolution copy number array in the molecular cytogenetic diagnostics of pediatric malignant hematological disorders

  • Authors:
    • Carina Wikhager
    • Inger Ögärd
    • Tommy Martinsson
    • Jonas Abrahamsson
    • Lars Palmqvist
    • Helene Sjögren

  • View Affiliations / Copyright

    Affiliations: Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, University of Gothenburg, Sahlgrenska University Hospital, SE-41345 Gothenburg, Sweden, Department of Clinical Genetics, Institute of Biomedicine, University of Gothenburg, Sahlgrenska University Hospital, SE-41345 Gothenburg, Sweden, Department of Pediatrics, The Queen Silvia Children's Hospital, SE-41685 Gothenburg, Sweden
  • Pages: 1429-1434
    |
    Published online on: February 16, 2012
       https://doi.org/10.3892/or.2012.1689
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Abstract

The presence of genetic alterations was investigated by SNP array in combination with conventional and spectral karyotyping and fluorescence in situ hybridization analysis of 75 consecutive pediatric bone marrow samples. The samples were collected at diagnosis from all children diagnosed with malignant hematological disease between 2006 and 2010 at a single diagnostic center in Gothenburg, Sweden. Conventional cytogenetic and molecular genetics techniques are up to this date essential for the clinical laboratories but there is a need for higher resolution techniques in order to identify new genetic markers that eventually can improve the management of these disorders. Here, we conclude that the addition of SNP array-based karyotyping combined with conventional cytogenetics increase the diagnostic accuracy of pediatric hematological malignancies. The two techniques enhance the cytogenetic image and should not be contrasted as they meet distinct important roles. Since balanced translocations cannot be detected with the SNP arrays of today and tumor-specific translocations are very important diagnostic and prognostic indicators we suggest that SNP-based array is a valuable adjuvant tool in the cytogenetic diagnostics of pediatric leukemias but cannot replace currently used techniques, i.e. G-banding, SKY and FISH analysis.

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Copy and paste a formatted citation
Spandidos Publications style
Wikhager C, Ögärd I, Martinsson T, Abrahamsson J, Palmqvist L and Sjögren H: High-resolution copy number array in the molecular cytogenetic diagnostics of pediatric malignant hematological disorders. Oncol Rep 27: 1429-1434, 2012.
APA
Wikhager, C., Ögärd, I., Martinsson, T., Abrahamsson, J., Palmqvist, L., & Sjögren, H. (2012). High-resolution copy number array in the molecular cytogenetic diagnostics of pediatric malignant hematological disorders. Oncology Reports, 27, 1429-1434. https://doi.org/10.3892/or.2012.1689
MLA
Wikhager, C., Ögärd, I., Martinsson, T., Abrahamsson, J., Palmqvist, L., Sjögren, H."High-resolution copy number array in the molecular cytogenetic diagnostics of pediatric malignant hematological disorders". Oncology Reports 27.5 (2012): 1429-1434.
Chicago
Wikhager, C., Ögärd, I., Martinsson, T., Abrahamsson, J., Palmqvist, L., Sjögren, H."High-resolution copy number array in the molecular cytogenetic diagnostics of pediatric malignant hematological disorders". Oncology Reports 27, no. 5 (2012): 1429-1434. https://doi.org/10.3892/or.2012.1689
Copy and paste a formatted citation
x
Spandidos Publications style
Wikhager C, Ögärd I, Martinsson T, Abrahamsson J, Palmqvist L and Sjögren H: High-resolution copy number array in the molecular cytogenetic diagnostics of pediatric malignant hematological disorders. Oncol Rep 27: 1429-1434, 2012.
APA
Wikhager, C., Ögärd, I., Martinsson, T., Abrahamsson, J., Palmqvist, L., & Sjögren, H. (2012). High-resolution copy number array in the molecular cytogenetic diagnostics of pediatric malignant hematological disorders. Oncology Reports, 27, 1429-1434. https://doi.org/10.3892/or.2012.1689
MLA
Wikhager, C., Ögärd, I., Martinsson, T., Abrahamsson, J., Palmqvist, L., Sjögren, H."High-resolution copy number array in the molecular cytogenetic diagnostics of pediatric malignant hematological disorders". Oncology Reports 27.5 (2012): 1429-1434.
Chicago
Wikhager, C., Ögärd, I., Martinsson, T., Abrahamsson, J., Palmqvist, L., Sjögren, H."High-resolution copy number array in the molecular cytogenetic diagnostics of pediatric malignant hematological disorders". Oncology Reports 27, no. 5 (2012): 1429-1434. https://doi.org/10.3892/or.2012.1689
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