Metadherin regulates radioresistance in cervical cancer cells

  • Authors:
    • Ying Zhao
    • Meena S. Moran
    • Qifeng Yang
    • Qiao Liu
    • Cunzhong Yuan
    • Shuhui Hong
    • Beihua Kong
  • View Affiliations

  • Published online on: February 20, 2012     https://doi.org/10.3892/or.2012.1692
  • Pages: 1520-1526
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Abstract

Metadherin (MTDH) promotes cancer metastasis, chemoresistance, invasion and angiogenesis. Upregulation of MTDH is correlated with both progression and poor clinical outcome of many types of cancers; however, there is currently no information regarding the role of MTDH in radiation sensitivity. Here, we investigated the effects of MTDH on the radiosensitivity of cervical cancer cells using the SiHa cell line. We discovered that cervical cancer cells in which MTDH was knocked down had significantly increased radiosensitivity as measured by a clonogenic assay. MTDH knockdown cells also had increased apoptosis and a decreased proportion of cells arrested in the G2 phase after radiation treatment. MTDH knockdown also weakened the repair of DNA double-strand breaks (DSBs) induced by radiation. These results indicate that MTDH affects the radiosensitivity of cervical cancer cells and that MTDH may be a novel target to improve cervical cancer radiation response.

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May 2012
Volume 27 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
APA
Zhao, Y., Moran, M.S., Yang, Q., Liu, Q., Yuan, C., Hong, S., & Kong, B. (2012). Metadherin regulates radioresistance in cervical cancer cells. Oncology Reports, 27, 1520-1526. https://doi.org/10.3892/or.2012.1692
MLA
Zhao, Y., Moran, M. S., Yang, Q., Liu, Q., Yuan, C., Hong, S., Kong, B."Metadherin regulates radioresistance in cervical cancer cells". Oncology Reports 27.5 (2012): 1520-1526.
Chicago
Zhao, Y., Moran, M. S., Yang, Q., Liu, Q., Yuan, C., Hong, S., Kong, B."Metadherin regulates radioresistance in cervical cancer cells". Oncology Reports 27, no. 5 (2012): 1520-1526. https://doi.org/10.3892/or.2012.1692