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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2012 Volume 27 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2012 Volume 27 Issue 6

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Article

NRF2 is overexpressed in ovarian epithelial carcinoma and is regulated by gonadotrophin and sex-steroid hormones

  • Authors:
    • Hong Liao
    • Qian Zhou
    • Zhenbo Zhang
    • Qianqian Wang
    • Yunyan Sun
    • Xiaofang Yi
    • Youji Feng

  • View Affiliations / Copyright

    Affiliations: Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, P.R. China, Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated First People's Hospital, Shanghai, P.R. China, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, P.R. China
  • Pages: 1918-1924
    |
    Published online on: February 28, 2012
       https://doi.org/10.3892/or.2012.1700
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Abstract

Aberrant nuclear factor-erythroid 2 (NRF2) expression correlates with tumor development. We investigated NRF2 expression in ovarian epithelial carcinoma (OEC), aiming to identify associations with clinicopathological factors, hormones and induced reactive oxygen species (ROS). Immunohistochemical staining for NRF2 expression was performed on 10 benign cystadenomas, 4 boderline tumors and 64 OECs. Western blotting was used to determine the effects of hormones on NRF2 expression in OEC. NRF2 protein was found to be overexpressed in OEC. Gonadotrophins and estrogen induced ROS production in OEC; these hormones also enhanced NRF2 expression. Therefore, aberrant expression may be induced by hormones through ROS signaling. Increased NRF2 expression may be a molecular event in OEC carcinogenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Liao H, Zhou Q, Zhang Z, Wang Q, Sun Y, Yi X and Feng Y: NRF2 is overexpressed in ovarian epithelial carcinoma and is regulated by gonadotrophin and sex-steroid hormones. Oncol Rep 27: 1918-1924, 2012.
APA
Liao, H., Zhou, Q., Zhang, Z., Wang, Q., Sun, Y., Yi, X., & Feng, Y. (2012). NRF2 is overexpressed in ovarian epithelial carcinoma and is regulated by gonadotrophin and sex-steroid hormones. Oncology Reports, 27, 1918-1924. https://doi.org/10.3892/or.2012.1700
MLA
Liao, H., Zhou, Q., Zhang, Z., Wang, Q., Sun, Y., Yi, X., Feng, Y."NRF2 is overexpressed in ovarian epithelial carcinoma and is regulated by gonadotrophin and sex-steroid hormones". Oncology Reports 27.6 (2012): 1918-1924.
Chicago
Liao, H., Zhou, Q., Zhang, Z., Wang, Q., Sun, Y., Yi, X., Feng, Y."NRF2 is overexpressed in ovarian epithelial carcinoma and is regulated by gonadotrophin and sex-steroid hormones". Oncology Reports 27, no. 6 (2012): 1918-1924. https://doi.org/10.3892/or.2012.1700
Copy and paste a formatted citation
x
Spandidos Publications style
Liao H, Zhou Q, Zhang Z, Wang Q, Sun Y, Yi X and Feng Y: NRF2 is overexpressed in ovarian epithelial carcinoma and is regulated by gonadotrophin and sex-steroid hormones. Oncol Rep 27: 1918-1924, 2012.
APA
Liao, H., Zhou, Q., Zhang, Z., Wang, Q., Sun, Y., Yi, X., & Feng, Y. (2012). NRF2 is overexpressed in ovarian epithelial carcinoma and is regulated by gonadotrophin and sex-steroid hormones. Oncology Reports, 27, 1918-1924. https://doi.org/10.3892/or.2012.1700
MLA
Liao, H., Zhou, Q., Zhang, Z., Wang, Q., Sun, Y., Yi, X., Feng, Y."NRF2 is overexpressed in ovarian epithelial carcinoma and is regulated by gonadotrophin and sex-steroid hormones". Oncology Reports 27.6 (2012): 1918-1924.
Chicago
Liao, H., Zhou, Q., Zhang, Z., Wang, Q., Sun, Y., Yi, X., Feng, Y."NRF2 is overexpressed in ovarian epithelial carcinoma and is regulated by gonadotrophin and sex-steroid hormones". Oncology Reports 27, no. 6 (2012): 1918-1924. https://doi.org/10.3892/or.2012.1700
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