Journal Articles

Open Access

The PI3K/Akt inhibitor LY294002 reverses BCRP-mediated drug resistance without affecting BCRP translocation

Yasuo Imai, Mayumi Yoshimori, Kazunori Fukuda, Hidetsugu Yamagishi, Yoshihiko Ueda

Pages: 1703-1709 Published online on: 15 March 2012
Open Access

EPHX1 polymorphisms do not modify esophageal carcinoma susceptibility in Dutch Caucasians

Polat Dura, Caro V.V. Bregitha, Rene H.M. Te Morsche, Hennie M.J. Roelofs, Jon O. Kristinsson, Theo Wobbes, Ben J.M. Witteman, Adriaan C.I.T.L. Tan, Joost P.H. Drenth, Wilbert H.M. Peters

Pages: 1710-1716 Published online on: 19 March 2012
Open Access

The accumulation of DNA demethylation in Sat α in normal gastric tissues with Helicobacter pylori infection renders susceptibility to gastric cancer in some individuals

Masaaki Saito, Koichi Suzuki, Takafumi Maeda, Takaharu Kato, Hidenori Kamiyama, Kei Koizumi, Yuichiro Miyaki, Shinichiro Okada, Hirokazu Kiyozaki, Fumio Konishi

Pages: 1717-1725 Published online on: 12 March 2012
Open Access

SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice

Kensuke Suzuki, Ryuji Hayashi, Tomomi Ichikawa, Shingo Imanishi, Toru Yamada, Minehiko Inomata, Toshiro Miwa, Shoko Matsui, Isao Usui, Masaharu Urakaze, Yuji Matsuya, Hirofumi Ogawa, Hiroaki Sakurai, Ikuo Saiki, Kazuyuki Tobe

Pages: 1726-1732 Published online on: 27 March 2012

Expression of Cav-1 in tumour cells, rather than in stromal tissue, may promote cervical squamous cell carcinoma proliferation, and correlates with high-risk HPV infection

Jun Sun, Jun Gao, Jun Bo Hu, Li Fang Fan, Xiao Bo Zhu, Roz Subahan, Hong Lei Chen

Pages: 1733-1740 Published online on: 28 February 2012

Prognostic significance of aquaporins in human biliary tract carcinoma

Shinichi Sekine, Yutaka Shimada, Takuya Nagata, Makoto Moriyama, Tetsuya Omura, Tomoko Watanabe, Ryouta Hori, Isaku Yoshioka, Tomoyuki Okumura, Shigeaki Sawada, Junya Fukuoka, Kazuhiro Tsukada

Pages: 1741-1747 Published online on: 27 March 2012

Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro

Junkoh Yamamoto, Shun-Ichiro Ogura, Tohru Tanaka, Takehiro Kitagawa, Yoshiteru Nakano, Takeshi Saito, Mayu Takahashi, Daisuke Akiba, Shigeru Nishizawa

Pages: 1748-1752 Published online on: 28 February 2012

The cytotoxic effect of TGF-β1 on mesothelial cells via apoptosis in early peritoneal carcinomatosis

Zhi-Dong Lv, Zhao-Chuan Yang, Hai-Bo Wang, Jian-Guo Li, Bin Kong, Xin-Gang Wang, Xiao-Yi Liu, Zhao-He Niu, Yu Wang, Gang Nie

Pages: 1753-1758 Published online on: 19 March 2012

Clinicopathological and prognostic significance of microRNA-107 and its relationship to DICER1 mRNA expression in gastric cancer

Taisuke Inoue, Hisae Iinuma, Etsushi Ogawa, Tsuyoshi Inaba, Ryoji Fukushima

Pages: 1759-1764 Published online on: 07 March 2012

Interleukin-4 and CpG oligonucleotide therapy suppresses the outgrowth of tumors by activating tumor-specific Th1-type immune responses

Atsushi Kajiwara, Hiroyoshi Doi, Junichi Eguchi, Shigeaki Ishii, Ayako Hiraide-Sasagawa, Masashi Sakaki, Risa Omori, Kazumasa Hiroishi, Michio Imawari

Pages: 1765-1771 Published online on: 15 March 2012

Pheophorbide a-mediated photodynamic therapy induces apoptotic cell death in murine oral squamous cell carcinoma in vitro and in vivo

Mee-Young Ahn, Seong-Min Kwon, Yong-Chul Kim, Sang-Gun Ahn, Jung-Hoon Yoon

Pages: 1772-1778 Published online on: 27 March 2012

Dual inhibition of sphingosine kinase isoforms ablates TNF-induced drug resistance

James W. Antoon, Martin D. White, Matthew E. Burow, Barbara S. Beckman

Pages: 1779-1786 Published online on: 27 March 2012

Implications of cleaved caspase 3 and AIF expression in colorectal cancer based on patient age

Aurélie Perraud, Hussein Akil, Michelle Nouaille, Daniel Petit, François Labrousse, Marie-Odile Jauberteau, Muriel Mathonnet

Pages: 1787-1793 Published online on: 20 March 2012

Patients with peritoneal mesothelioma lack epidermal growth factor receptor tyrosine kinase mutations that would make them sensitive to tyrosine kinase inhibitors

Neetu Kalra, Ali Ashai, Liqiang Xi, Jingli Zhang, Itzhak Avital, Mark Raffeld, Raffit Hassan

Pages: 1794-1800 Published online on: 15 March 2012

Expression of high-risk HPV DNA and CK19 in pelvic lymph nodes in stage Ⅰa-Ⅱa cervical cancer and their clinical value

Fan Zhang, Dawo Liu, Bei Lin, Yingying Hao, Dan Zhou, Yue Qi, Shulan Zhang

Pages: 1801-1806 Published online on: 07 March 2012

Basic fibroblast growth factor in an animal model of spontaneous mammary tumor progression

Steven Kao, Jeffrey Mo, Andrew Baird, Brian P. Eliceiri

Pages: 1807-1814 Published online on: 07 March 2012

A unique MUC1-2-VNTR DNA vaccine suppresses tumor growth and prolongs survival in a murine multiple myeloma model

Yuhui Weng, Liang Shao, Hongmei Ouyang, Yuebo Liu, Jin Yao, Hong Yang, Yunjiao Luo, Hao Wang, Zhenyu Zhao, Hong Mou, Zeping Zhou, You Zhang

Pages: 1815-1822 Published online on: 07 March 2012

Antitumor effects of genetically engineered stem cells expressing yeast cytosine deaminase in lung cancer brain metastases via their tumor-tropic properties

Bo-Rim Yi, Seung U. Kim, Yun-Bae Kim, Hong Jun Lee, Myung-Haing Cho, Kyung-Chul Choi

Pages: 1823-1828 Published online on: 13 March 2012

Effects of silencing cyclooxygenase-2 expression via RNA interference on the tumorigenicity of the SMMC-7721 human hepatocarcinoma cell line

Li-Li Liu, Li-Rong Lin, Man-Li Tong, Zuo-Gen Fu, Gui-Li Liu, Wei-Hong  Zheng, Fan Liu, Dai-Wei Zhang, Zhong-Ying Zhang, Tian-Ci Yang

Pages: 1829-1834 Published online on: 28 February 2012

Tiam1, negatively regulated by miR-22, miR-183 and miR-31, is involved in migration, invasion and viability of ovarian cancer cells

Jun Li, Shanhui Liang, Hongyan Jin, Congjian Xu, Duan Ma, Xin Lu

Pages: 1835-1842 Published online on: 27 March 2012

Evaluation of MAGE A1 in oral squamous cell carcinoma

Cláudia Maria Pereira, Carolina Cavaliéri Gomes, Jeane De Fátima Correia Silva, Monica Bucciarelli Rodriguez, Alvimar Afonso Barbosa, Ricardo Santiago Gomez

Pages: 1843-1848 Published online on: 19 March 2012

Role of systemic chemotherapy in the management of resected or resectable colorectal liver metastases: a systematic review and meta-analysis of randomized controlled trials

Domenico Ciliberto, Ubaldo Prati, Laura Roveda, Vito Barbieri, Nicoletta Staropoli, Alberto Abbruzzese, Michele Caraglia, Massimo Di Maio, Domenico Flotta, Pierfrancesco Tassone, Pierosandro Tagliaferri

Pages: 1849-1856 Published online on: 22 March 2012

Apoptosis induced by 7-difluoromethoxyl-5,4'-di-n-octyl genistein via the inactivation of FoxM1 in ovarian cancer cells

Yingxia Ning, Qingxiu Li, Honglin Xiang, Fei Liu, Jianguo Cao

Pages: 1857-1864 Published online on: 22 March 2012

Tumorigenicity of cancer stem-like cells derived from hepatocarcinoma is regulated by microRNA-145

Yongsheng Jia, Honglin Liu, Qianshu Zhuang, Shiqing Xu, Zhihua Yang, Jianzhong Li, Jinning Lou, Wenjian Zhang

Pages: 1865-1872 Published online on: 28 February 2012

Luteinizing hormone facilitates angiogenesis in ovarian epithelial tumor cells and metformin inhibits the effect through the mTOR signaling pathway

Hong Liao, Qian Zhou, Yanqiong Gu, Tao Duan, Youji Feng

Pages: 1873-1878 Published online on: 27 March 2012

Role of PKC-ERK signaling in tamoxifen-induced apoptosis and tamoxifen resistance in human breast cancer cells

Zhihua Li, Na Wang, Jieyu Fang, Jintao Huang, Fen  Tian, Chaohong Li, Fukang Xie

Pages: 1879-1886 Published online on: 15 March 2012

Transcriptional upregulation of HER2 expression in the absence of HER2 gene amplification results in cetuximab resistance that is reversed by trastuzumab treatment

Cristina Oliveras-Ferraros, Anna Massaguer Vall-Llovera, Alejandro Vazquez-Martin, Dolors Carrion Salip, Bernardo Queralt, Silvia Cufí, Begoña Martin-Castillo, Joaquim Bosch-Barrera, Joan Brunet, Rafael De Llorens, Javier A. Menendez

Pages: 1887-1892 Published online on: 15 March 2012

Angiotensin II receptor type 1 blockers suppress the cell proliferation effects of angiotensin II in breast cancer cells by inhibiting AT1R signaling

Ning Du, Jiang Feng, Li-Juan Hu, Xin Sun, Hai-Bing Sun, Yang Zhao, Yi-Ping Yang, Hong Ren

Pages: 1893-1903 Published online on: 13 March 2012

The heat shock protein 90 inhibitor SNX-2112 inhibits B16 melanoma cell growth in vitro and in vivo

Kai-Sheng Liu, Wei-Chao Ding, Shao-Xiang Wang, Zhong Liu, Guo-Wen Xing, Ying Wang, Yi-Fei Wang

Pages: 1904-1910 Published online on: 22 March 2012

Involvement of Mcl1 in diallyl disulfide-induced G2/M cell cycle arrest in HL-60 cells

Lan Yi, Xiao-Xia Ji, Hui Tan, Mei-Yan Feng, Yi Tang, Ling Wen, Qi Su

Pages: 1911-1917 Published online on: 28 February 2012

NRF2 is overexpressed in ovarian epithelial carcinoma and is regulated by gonadotrophin and sex-steroid hormones

Hong Liao, Qian Zhou, Zhenbo Zhang, Qianqian Wang, Yunyan Sun, Xiaofang Yi, Youji Feng

Pages: 1918-1924 Published online on: 28 February 2012

In vivo and in situ imaging of head and neck squamous cell carcinoma using near-infrared fluorescent quantum dot probes conjugated with epidermal growth factor receptor monoclonal antibodies in mice

Kai Yang, Cheng Zhao, Yu-An Cao, Hong Tang, Yun-Long Bai, Hao Huang, Chuen-Rong Zhao, Rui Chen, Dan Zhao

Pages: 1925-1931 Published online on: 29 February 2012

A new bioinformatics insight into human cancer-associated proteins

Fu-Jun Liu, Xiu-Feng Hua, Wen-Juan Wang

Pages: 1932-1936 Published online on: 12 March 2012

Real-time bioluminescence and tomographic imaging of gastric cancer in a novel orthotopic mouse model

Hao Hu, Junting Liu, Liping Yao, Jipeng Yin, Ning Su, Xiangqiang Liu, Feng Cao, Jimin Liang, Yongzhan Nie, Kaichun Wu

Pages: 1937-1943 Published online on: 07 March 2012

The effect of NET-1 on the proliferation, migration and endocytosis of the SMMC-7721 HCC cell line

Gui-Lan Wang, Li Chen, Ying-Ze Wei, Jia-Ming Zhou, Yuan-Yuan Wu, Yi-Xin Zhang, Jing Qin, Yuan-Yuan Zhu

Pages: 1944-1952 Published online on: 28 February 2012

The expression of ARHI in pT2a and pT2b stage gastric cancer and its clinical significance

Wei Wang, Xian-Min Bu, Jian Wang, Ning Zhang, Cheng-Hai Zhao

Pages: 1953-1959 Published online on: 15 March 2012

microRNA-155 is downregulated in gastric cancer cells and involved in cell metastasis

Cheng-Long Li, Hui Nie, Ming Wang, Li-Ping Su, Jian-Fang Li, Ying-Yan Yu, Min Yan, Qin-Long Qu, Zheng-Gang Zhu, Bing-Ya Liu

Pages: 1960-1966 Published online on: 13 March 2012

microRNA-133 inhibits cell proliferation, migration and invasion in prostate cancer cells by targeting the epidermal growth factor receptor

Jun Tao, Deyao Wu, Bin Xu, Weichun Qian, Pengchao Li, Qiang Lu, Changjun Yin, Wei Zhang

Pages: 1967-1975 Published online on: 07 March 2012

Jolkinolide B induces apoptosis in MDA-MB-231 cells through inhibition of the PI3K/Akt signaling pathway

Yu Lin, Hongxia Cui, Huiyu Xu, Liling Yue, Hao Xu, Liyan Jiang, Jicheng Liu

Pages: 1976-1980 Published online on: 12 March 2012

Establishment of a bioluminescent MDA-MB-231 cell line for human triple-negative breast cancer research

Ke Wang, Simei Xie, Yu Ren, Haibin Xia, Xinwei Zhang, Jianjun He

Pages: 1981-1989 Published online on: 22 March 2012

Overexpression of HIF-1α in primary gallbladder carcinoma and its relation to vasculogenic mimicry and unfavourable prognosis

Wei Sun, Zhen-Yu Shen, Hui Zhang, Yue-Zu Fan, Wen-Zhong Zhang, Jing-Tao Zhang, Xing-Sui Lu, Chun Ye

Pages: 1990-2002 Published online on: 27 March 2012

CD147 silencing via RNA interference reduces tumor cell invasion, metastasis and increases chemosensitivity in pancreatic cancer cells

Yuqin Pan, Bangshun He, Guoqi Song, Qian Bao, Zhipeng Tang, Fuliang Tian, Shukui Wang

Pages: 2003-2009 Published online on: 15 March 2012

Livin mediates tumor cell invasion in the DU-145 cell line via NF-κB

Feng Chen, Deyong Yang, Xiangyu Che, Jianbo Wang, Xiancheng Li, Zhiwei Zhang, Xiaochi Chen, Xishuang Song

Pages: 2010-2016 Published online on: 15 March 2012

Expression of estrogen receptor β1 in colorectal cancer: Correlation with clinicopathological variables

Lea Rath-Wolfson, Ofer Purim, Edward Ram, Sara Morgenstern, Rumelia Koren, Baruch Brenner

Pages: 2017-2022 Published online on: 07 March 2012

Docosahexaenoic acid sensitizes colon cancer cells to sulindac sulfide-induced apoptosis

Soo-Jeong Lim, Eunmyong Lee, Eun-Hye Lee, Soo-Yeon Kim, Jun Hyung Cha, Hwanho Choi, Wanseo Park, Hyeon Kyeom Choi, Seong-Hee Ko, So Hee Kim

Pages: 2023-2030 Published online on: 06 March 2012

Evidence that aberrant protein metabolism contributes to chemoresistance in multiple myeloma cells

Richard K. Sipes, Xue Xia, Brian S. Lewis, Nicholas E. Burgis

Pages: 2031-2038 Published online on: 12 March 2012

Type II cGMP-dependent protein kinase inhibits EGF-induced MAPK/JNK signal transduction in breast cancer cells

Ting Lan, Yongchang Chen, Jianrong Sang, Yan Wu, Ying Wang, Lu Jiang, Yan Tao

Pages: 2039-2044 Published online on: 15 March 2012

Rab15 alternative splicing is altered in spheres of neuroblastoma cells

Thi Van Huyen Pham, Tri Budi Hartomo, Myeong Jin Lee, Daiichiro Hasegawa, Toshiaki Ishida, Keiichiro Kawasaki, Yoshiyuki Kosaka, Tomoto Yamamoto, Satoru Morikawa, Nobuyuki Yamamoto, Ikuko Kubokawa, Takeshi  Mori, Tomoko Yanai, Akira Hayakawa, Yasuhiro Takeshima, Kazumoto Iijima, Masafumi Matsuo, Hisahide Nishio, Noriyuki Nishimura

Pages: 2045-2049 Published online on: 15 March 2012

Resveratrol reverses temozolomide resistance by downregulation of MGMT in T98G glioblastoma cells by the NF-κB-dependent pathway

Huiyong Huang, Hong Lin, Xiang Zhang, Juan Li

Pages: 2050-2056 Published online on: 12 March 2012

Involvement of ER-α36, Src, EGFR and STAT5 in the biphasic estrogen signaling of ER-negative breast cancer cells

Xin-Tian Zhang, Ling Ding, Lian-Guo Kang, Zhao-Yi Wang

Pages: 2057-2065 Published online on: 15 March 2012

Effects of icotinib, a novel epidermal growth factor receptor tyrosine kinase inhibitor, in EGFR-mutated non-small cell lung cancer

Guangdie Yang, Yinan Yao, Jianya Zhou, Qiong Zhao

Pages: 2066-2072 Published online on: 22 March 2012

Prognostic significance of metadherin overexpression in hepatitis B virus-related hepatocellular carcinoma

Zhenbin Gong, Weihui Liu, Nan You, Tao Wang, Xing Wang, Peng Lu, Ge Zhao, Ping Yang, Desheng Wang, Kefeng Dou

Pages: 2073-2079 Published online on: 27 March 2012

Involvement of NF-κB-mediated expression of galectin-3-binding protein in TNF-α-induced breast cancer cell adhesion

Naruto Noma, Siro Simizu, Yusuke Kambayashi, Yasuaki Kabe, Makoto Suematsu, Kazuo Umezawa

Pages: 2080-2084 Published online on: 19 March 2012
Journal Cover

June 2012
Volume 27 Issue 6

Print ISSN: 1021-335X
Online ISSN: 1791-2431

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