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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2012 Volume 27 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2012 Volume 27 Issue 6

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Article

Expression of estrogen receptor β1 in colorectal cancer: Correlation with clinicopathological variables

  • Authors:
    • Lea Rath-Wolfson
    • Ofer Purim
    • Edward Ram
    • Sara Morgenstern
    • Rumelia Koren
    • Baruch Brenner

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Hasharon Hospital, Petah Tikva, Israel, Department of Oncology, Belinson Hospital, Petah Tikva, Israel, Department of Surgery ‘A’, Hasharon Hospital, Petah Tikva, Israel, Department of Pathology, Belinson Hospital, Rabin Medical Center, Petah Tikva, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Petah Tikva, Israel
  • Pages: 2017-2022
    |
    Published online on: March 7, 2012
       https://doi.org/10.3892/or.2012.1712
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Abstract

Colorectal cancer (CRC) is a common malignancy in both genders with a high death rate, accounting for about 56,000 each year in the USA only. In this study we examined the differences in CRC between the genders. We also looked for differences in the staining of the tumors and adjacent colonic mucosa to estrogen receptor β1 and its possible prognostic value. Fifty-five specimens from patients who underwent resection of colon cancer in our institute were sectioned and stained for estrogen receptor β1. The histopathological slides were evaluated for positive staining in the tumor and the normal colonic mucosa as well. The results were statistically analyzed. Positive estrogen receptor β1 stain was found in the nuclei of the tumor cells. We noted positive stain also in the cytoplasm of the tumor cells. Similar findings were observed in the normal colonic mucosa. Statistically significant differences were found regarding the positivity of the staining between the deceased and surviving patients, men/women and those who had metastases vs. the non-metastatic ones. Our data suggest that there is an estrogen influence on the development and progression of colon cancer. Furthermore, it was found to be higher in the more severe cases.

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Copy and paste a formatted citation
Spandidos Publications style
Rath-Wolfson L, Purim O, Ram E, Morgenstern S, Koren R and Brenner B: Expression of estrogen receptor β1 in colorectal cancer: Correlation with clinicopathological variables. Oncol Rep 27: 2017-2022, 2012.
APA
Rath-Wolfson, L., Purim, O., Ram, E., Morgenstern, S., Koren, R., & Brenner, B. (2012). Expression of estrogen receptor β1 in colorectal cancer: Correlation with clinicopathological variables. Oncology Reports, 27, 2017-2022. https://doi.org/10.3892/or.2012.1712
MLA
Rath-Wolfson, L., Purim, O., Ram, E., Morgenstern, S., Koren, R., Brenner, B."Expression of estrogen receptor β1 in colorectal cancer: Correlation with clinicopathological variables". Oncology Reports 27.6 (2012): 2017-2022.
Chicago
Rath-Wolfson, L., Purim, O., Ram, E., Morgenstern, S., Koren, R., Brenner, B."Expression of estrogen receptor β1 in colorectal cancer: Correlation with clinicopathological variables". Oncology Reports 27, no. 6 (2012): 2017-2022. https://doi.org/10.3892/or.2012.1712
Copy and paste a formatted citation
x
Spandidos Publications style
Rath-Wolfson L, Purim O, Ram E, Morgenstern S, Koren R and Brenner B: Expression of estrogen receptor β1 in colorectal cancer: Correlation with clinicopathological variables. Oncol Rep 27: 2017-2022, 2012.
APA
Rath-Wolfson, L., Purim, O., Ram, E., Morgenstern, S., Koren, R., & Brenner, B. (2012). Expression of estrogen receptor β1 in colorectal cancer: Correlation with clinicopathological variables. Oncology Reports, 27, 2017-2022. https://doi.org/10.3892/or.2012.1712
MLA
Rath-Wolfson, L., Purim, O., Ram, E., Morgenstern, S., Koren, R., Brenner, B."Expression of estrogen receptor β1 in colorectal cancer: Correlation with clinicopathological variables". Oncology Reports 27.6 (2012): 2017-2022.
Chicago
Rath-Wolfson, L., Purim, O., Ram, E., Morgenstern, S., Koren, R., Brenner, B."Expression of estrogen receptor β1 in colorectal cancer: Correlation with clinicopathological variables". Oncology Reports 27, no. 6 (2012): 2017-2022. https://doi.org/10.3892/or.2012.1712
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