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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2012 Volume 27 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Jolkinolide B induces apoptosis in MDA-MB-231 cells through inhibition of the PI3K/Akt signaling pathway

  • Authors:
    • Yu Lin
    • Hongxia Cui
    • Huiyu Xu
    • Liling Yue
    • Hao Xu
    • Liyan Jiang
    • Jicheng Liu

  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Qiqihar Medical University, Qiqihar 161006, P.R. China, The Institute of Medicine, Qiqihar Medical Univeristy, Qiqihar 161006, P.R. China
  • Pages: 1976-1980
    |
    Published online on: March 12, 2012
       https://doi.org/10.3892/or.2012.1717
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Abstract

The phosphoinositol-3-kinase (PI3K)/Akt signal transduction pathway is critically important for tumor cell growth, proliferation and apoptosis. Apoptosis activation has been reported to be a good target in cancer therapies. In this study, we have found that jolkinolide B (JB), a diterpenoid from the traditional Chinese medicinal herb Euphorbia fischeriana Steud, strongly inhibited the expression of the PI3K p85 subunit and the phosphorylation of Akt. Furthermore, we evaluated the effects of JB on the proliferation and apoptosis of MDA-MB-231 human breast cancer cells. Our results show significant induction of apoptosis in MDA-MB-231 cells incubated with JB. This effect was enhanced by combination with LY294002. In addition, treatment with JB could induce downregulation of the Bcl-2/Bax ratio, and subsequent promotion of mitochondrial release of cytochrome c and activation of caspase-3. Taken together, JB-induced apoptosis of MDA-MB-231 cells occurs through the mitochondrial pathway. Further, the PI3K/Akt signaling cascade plays a role in the induction of apoptosis in JB-treated cells. These observations suggest that JB may have therapeutic applications in the treatment of cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Lin Y, Cui H, Xu H, Yue L, Xu H, Jiang L and Liu J: Jolkinolide B induces apoptosis in MDA-MB-231 cells through inhibition of the PI3K/Akt signaling pathway. Oncol Rep 27: 1976-1980, 2012.
APA
Lin, Y., Cui, H., Xu, H., Yue, L., Xu, H., Jiang, L., & Liu, J. (2012). Jolkinolide B induces apoptosis in MDA-MB-231 cells through inhibition of the PI3K/Akt signaling pathway. Oncology Reports, 27, 1976-1980. https://doi.org/10.3892/or.2012.1717
MLA
Lin, Y., Cui, H., Xu, H., Yue, L., Xu, H., Jiang, L., Liu, J."Jolkinolide B induces apoptosis in MDA-MB-231 cells through inhibition of the PI3K/Akt signaling pathway". Oncology Reports 27.6 (2012): 1976-1980.
Chicago
Lin, Y., Cui, H., Xu, H., Yue, L., Xu, H., Jiang, L., Liu, J."Jolkinolide B induces apoptosis in MDA-MB-231 cells through inhibition of the PI3K/Akt signaling pathway". Oncology Reports 27, no. 6 (2012): 1976-1980. https://doi.org/10.3892/or.2012.1717
Copy and paste a formatted citation
x
Spandidos Publications style
Lin Y, Cui H, Xu H, Yue L, Xu H, Jiang L and Liu J: Jolkinolide B induces apoptosis in MDA-MB-231 cells through inhibition of the PI3K/Akt signaling pathway. Oncol Rep 27: 1976-1980, 2012.
APA
Lin, Y., Cui, H., Xu, H., Yue, L., Xu, H., Jiang, L., & Liu, J. (2012). Jolkinolide B induces apoptosis in MDA-MB-231 cells through inhibition of the PI3K/Akt signaling pathway. Oncology Reports, 27, 1976-1980. https://doi.org/10.3892/or.2012.1717
MLA
Lin, Y., Cui, H., Xu, H., Yue, L., Xu, H., Jiang, L., Liu, J."Jolkinolide B induces apoptosis in MDA-MB-231 cells through inhibition of the PI3K/Akt signaling pathway". Oncology Reports 27.6 (2012): 1976-1980.
Chicago
Lin, Y., Cui, H., Xu, H., Yue, L., Xu, H., Jiang, L., Liu, J."Jolkinolide B induces apoptosis in MDA-MB-231 cells through inhibition of the PI3K/Akt signaling pathway". Oncology Reports 27, no. 6 (2012): 1976-1980. https://doi.org/10.3892/or.2012.1717
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