CD147 silencing via RNA interference reduces tumor cell invasion, metastasis and increases chemosensitivity in pancreatic cancer cells

  • Authors:
    • Yuqin Pan
    • Bangshun He
    • Guoqi Song
    • Qian Bao
    • Zhipeng Tang
    • Fuliang Tian
    • Shukui Wang
  • View Affiliations

  • Published online on: March 15, 2012     https://doi.org/10.3892/or.2012.1729
  • Pages: 2003-2009
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Abstract

CD147, which belongs to the immunoglobulin superfamily, is a multifunctional glycoprotein that has been shown to increase tumor invasion, metastasis and multidrug resistance. To define the role of CD147 in invasion and metastasis more precisely, we utilized gene silencing to inhibit the expression of CD147 in pancreatic cancer cells. We observed that CD147 expression was significantly impeded at both the mRNA and protein levels and resulted in a decrease of MMP-2 and MMP-9 activities. There was also a decrease of MCT1 expression in the invasion and metastasis potential of pancreatic cancer cells, as well as increased chemosensitivity to gemcitabine in Panc-1 cells. Overall, these results suggest that CD147 plays an important role in the invasion, metastasis and chemosensitivity of the human pancreatic cancer cell line Panc-1, indicating that CD147 may be a promising therapeutic target for pancreatic cancer.

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June 2012
Volume 27 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Pan Y, He B, Song G, Bao Q, Tang Z, Tian F and Wang S: CD147 silencing via RNA interference reduces tumor cell invasion, metastasis and increases chemosensitivity in pancreatic cancer cells. Oncol Rep 27: 2003-2009, 2012
APA
Pan, Y., He, B., Song, G., Bao, Q., Tang, Z., Tian, F., & Wang, S. (2012). CD147 silencing via RNA interference reduces tumor cell invasion, metastasis and increases chemosensitivity in pancreatic cancer cells. Oncology Reports, 27, 2003-2009. https://doi.org/10.3892/or.2012.1729
MLA
Pan, Y., He, B., Song, G., Bao, Q., Tang, Z., Tian, F., Wang, S."CD147 silencing via RNA interference reduces tumor cell invasion, metastasis and increases chemosensitivity in pancreatic cancer cells". Oncology Reports 27.6 (2012): 2003-2009.
Chicago
Pan, Y., He, B., Song, G., Bao, Q., Tang, Z., Tian, F., Wang, S."CD147 silencing via RNA interference reduces tumor cell invasion, metastasis and increases chemosensitivity in pancreatic cancer cells". Oncology Reports 27, no. 6 (2012): 2003-2009. https://doi.org/10.3892/or.2012.1729