Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway

  • Authors:
    • Jae Hun Cha
    • Yoon Ji Choi
    • Seung Heon Cha
    • Chang Hwa Choi
    • Won Ho Cho
  • View Affiliations

  • Published online on: April 23, 2012     https://doi.org/10.3892/or.2012.1772
  • Pages: 41-48
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Abstract

Allicin, the main flavor compound in garlic, has anti-carcinogenic activities in a range of cancer cells, however, the underlying molecular mechanisms are not completely understood. This study examined the effect of allicin on the cell viability of U87MG human glioma cells along with its molecular mechanisms of induction of cell death. Apoptosis was determined by TUNEL and Hoechst 33258 staining as well as by western blot analysis. Allicin inhibited the cell viability of U87MG human glioma cells in a dose- and time-dependent manner. Allicin-induced inhibition of cell viability was due to apoptosis of cells. The mechanisms of apoptosis were found to involve the mitochondrial pathway of Bcl-2/Bax, the MAPK/ERK signaling pathway and antioxidant enzyme systems. These results suggest that allicin can serve as a novel chemotherapeutic candidate for the treatment of glioblastoma multiforme.

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July 2012
Volume 28 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Cha J, Choi Y, Cha S, Choi C and Cho W: Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway. Oncol Rep 28: 41-48, 2012
APA
Cha, J., Choi, Y., Cha, S., Choi, C., & Cho, W. (2012). Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway. Oncology Reports, 28, 41-48. https://doi.org/10.3892/or.2012.1772
MLA
Cha, J., Choi, Y., Cha, S., Choi, C., Cho, W."Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway". Oncology Reports 28.1 (2012): 41-48.
Chicago
Cha, J., Choi, Y., Cha, S., Choi, C., Cho, W."Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway". Oncology Reports 28, no. 1 (2012): 41-48. https://doi.org/10.3892/or.2012.1772