Effects of trichostatin A on HIF-1α and VEGF expression in human tongue squamous cell carcinoma cells in vitro

  • Authors:
    • Fei-Wu Kang
    • Lin Que
    • Min Wu
    • Zuo-Lin Wang
    • Jing Sun
  • View Affiliations

  • Published online on: April 23, 2012     https://doi.org/10.3892/or.2012.1784
  • Pages: 193-199
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Abstract

Hypoxia is an essential feature of the microenvironment of solid tumors, which regulates a variety of transcription factors including hypoxia-inducible factor-1α (HIF-1α). HIF-1α overexpression enhances tumor angiogenesis via upregulation of vascular endothelial growth factor (VEGF) and some other hypoxia-inducible angiogenic factors, which lead to a more aggressive tumor phenotype, tumor metastasis and resistance to radiation and chemotherapy. In this study, we found that a histone deacetylase (HDAC) inhibitor, trichostatin A (TSA), inhibited cell proliferation and invasion, blocked the cell cycle, and induced cell apoptosis in a dose- and time-dependent manner in the human tongue squamous cell carcinoma (TSCC) SCC-6 cell line in vitro. Furthermore, TSA reduced both basal levels and hypoxia-induced HIF-1α protein accumulation but not HIF-1α mRNA levels, and both protein and mRNA levels of VEGF expression. These results showed that TSA had a potent anticancer activity on TSCC cells, suggesting that TSA could be a promising drug targeting tumor angiogenesis via inhibition of HIF-1α and VEGF expression in the development of an effective chemopreventive and anticancer agent on human TSCCs.

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July 2012
Volume 28 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kang F, Que L, Wu M, Wang Z and Sun J: Effects of trichostatin A on HIF-1α and VEGF expression in human tongue squamous cell carcinoma cells in vitro. Oncol Rep 28: 193-199, 2012.
APA
Kang, F., Que, L., Wu, M., Wang, Z., & Sun, J. (2012). Effects of trichostatin A on HIF-1α and VEGF expression in human tongue squamous cell carcinoma cells in vitro. Oncology Reports, 28, 193-199. https://doi.org/10.3892/or.2012.1784
MLA
Kang, F., Que, L., Wu, M., Wang, Z., Sun, J."Effects of trichostatin A on HIF-1α and VEGF expression in human tongue squamous cell carcinoma cells in vitro". Oncology Reports 28.1 (2012): 193-199.
Chicago
Kang, F., Que, L., Wu, M., Wang, Z., Sun, J."Effects of trichostatin A on HIF-1α and VEGF expression in human tongue squamous cell carcinoma cells in vitro". Oncology Reports 28, no. 1 (2012): 193-199. https://doi.org/10.3892/or.2012.1784