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Article

β-elemene induces glioma cell apoptosis by downregulating survivin and its interaction with hepatitis B X-interacting protein

  • Authors:
    • Hang Zhang
    • Feng Xu
    • Tian Xie
    • Hongchuan Jin
    • Liyun Shi
  • View Affiliations / Copyright

    Affiliations: Department of Basic Medical Science, Hangzhou Normal University, Hangzhou, Zhejiang, P.R. China, Department of Respiratory Medicine, Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, P.R. Chin, Research Center for Biomedicine and Health, Hangzhou Normal University, Hangzhou, Zhejiang, P.R. China, Laboratory of Cancer Epigenetics, Key Laboratory of Biotherapy in Zhejiang Province, Biomedical Research Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P.R. China
  • Pages: 2083-2090
    |
    Published online on: September 11, 2012
       https://doi.org/10.3892/or.2012.2022
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Abstract

β-elemene, extracted from the ginger plant, possesses antitumor activity against a broad range of cancers clinically. However, the mechanism underlying β-elemene-induced cytotoxicity remains incompletely understood. Here, we show that β-elemene promoted apoptotic cell death in human glioma cells, downregulated survivin gene expression, and induced caspase-9, -3 and -7 activities. Induction of apoptosis was associated with inhibition of survivin gene expression, and restoration of survivin levels remarkably attenuated β-elemene-induced glioma cell death. Moreover, we found that the interaction between surviving and HBXIP, a critical regulator of caspase-9 activity, was impaired by β-elemene treatment. The results, therefore, reveal a caspase-mediated apoptotic pathway induced by β-elemene in human glioma cells, which is associated with downregulation of survivin itself and the interaction between survivin and HBXP.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang H, Xu F, Xie T, Jin H and Shi L: β-elemene induces glioma cell apoptosis by downregulating survivin and its interaction with hepatitis B X-interacting protein. Oncol Rep 28: 2083-2090, 2012.
APA
Zhang, H., Xu, F., Xie, T., Jin, H., & Shi, L. (2012). β-elemene induces glioma cell apoptosis by downregulating survivin and its interaction with hepatitis B X-interacting protein. Oncology Reports, 28, 2083-2090. https://doi.org/10.3892/or.2012.2022
MLA
Zhang, H., Xu, F., Xie, T., Jin, H., Shi, L."β-elemene induces glioma cell apoptosis by downregulating survivin and its interaction with hepatitis B X-interacting protein". Oncology Reports 28.6 (2012): 2083-2090.
Chicago
Zhang, H., Xu, F., Xie, T., Jin, H., Shi, L."β-elemene induces glioma cell apoptosis by downregulating survivin and its interaction with hepatitis B X-interacting protein". Oncology Reports 28, no. 6 (2012): 2083-2090. https://doi.org/10.3892/or.2012.2022
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang H, Xu F, Xie T, Jin H and Shi L: β-elemene induces glioma cell apoptosis by downregulating survivin and its interaction with hepatitis B X-interacting protein. Oncol Rep 28: 2083-2090, 2012.
APA
Zhang, H., Xu, F., Xie, T., Jin, H., & Shi, L. (2012). β-elemene induces glioma cell apoptosis by downregulating survivin and its interaction with hepatitis B X-interacting protein. Oncology Reports, 28, 2083-2090. https://doi.org/10.3892/or.2012.2022
MLA
Zhang, H., Xu, F., Xie, T., Jin, H., Shi, L."β-elemene induces glioma cell apoptosis by downregulating survivin and its interaction with hepatitis B X-interacting protein". Oncology Reports 28.6 (2012): 2083-2090.
Chicago
Zhang, H., Xu, F., Xie, T., Jin, H., Shi, L."β-elemene induces glioma cell apoptosis by downregulating survivin and its interaction with hepatitis B X-interacting protein". Oncology Reports 28, no. 6 (2012): 2083-2090. https://doi.org/10.3892/or.2012.2022
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