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Article

Sanguinarine inhibits growth of human cervical cancer cells through the induction of apoptosis

  • Authors:
    • Jia-Ying Xu
    • Qing-Hui Meng
    • Yu Chong
    • Yang Jiao
    • Lin Zhao
    • Eliot M. Rosen
    • Saijun Fan
  • View Affiliations / Copyright

    Affiliations: School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, Jiangsu 215123, P.R. China, Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
  • Pages: 2264-2270
    |
    Published online on: September 11, 2012
       https://doi.org/10.3892/or.2012.2024
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Abstract

Sanguinarine, a natural benzophenanthridine alkaloid, has been shown to possess anticancer activity in vitro and in vivo. In the present study, we demonstrated that sanguinarine caused a dose-dependent inhibition of growth in HeLa and SiHa human cervical cancer cells, i.e., 2.43 µmol/l (IC50) in HeLa cells and 3.07 µmol/l in SiHa cells. Cell cycle analysis revealed that sanguinarine significantly increased the sub-G1 population, from 1.7 to 59.7% in HeLa cells and from 1.7 to 41.7% in SiHa cells. Sanguinarine caused a dose-dependent decrease in Bcl-2 and NF-κB protein expression and a significant increase in Bax protein expression. Our findings indicate that sanguinarine as an effective anticancer drug candidate inhibits the growth of cervical cancer cells through the induction of apoptosis.
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Copy and paste a formatted citation
Spandidos Publications style
Xu J, Meng Q, Chong Y, Jiao Y, Zhao L, Rosen EM and Fan S: Sanguinarine inhibits growth of human cervical cancer cells through the induction of apoptosis. Oncol Rep 28: 2264-2270, 2012.
APA
Xu, J., Meng, Q., Chong, Y., Jiao, Y., Zhao, L., Rosen, E.M., & Fan, S. (2012). Sanguinarine inhibits growth of human cervical cancer cells through the induction of apoptosis. Oncology Reports, 28, 2264-2270. https://doi.org/10.3892/or.2012.2024
MLA
Xu, J., Meng, Q., Chong, Y., Jiao, Y., Zhao, L., Rosen, E. M., Fan, S."Sanguinarine inhibits growth of human cervical cancer cells through the induction of apoptosis". Oncology Reports 28.6 (2012): 2264-2270.
Chicago
Xu, J., Meng, Q., Chong, Y., Jiao, Y., Zhao, L., Rosen, E. M., Fan, S."Sanguinarine inhibits growth of human cervical cancer cells through the induction of apoptosis". Oncology Reports 28, no. 6 (2012): 2264-2270. https://doi.org/10.3892/or.2012.2024
Copy and paste a formatted citation
x
Spandidos Publications style
Xu J, Meng Q, Chong Y, Jiao Y, Zhao L, Rosen EM and Fan S: Sanguinarine inhibits growth of human cervical cancer cells through the induction of apoptosis. Oncol Rep 28: 2264-2270, 2012.
APA
Xu, J., Meng, Q., Chong, Y., Jiao, Y., Zhao, L., Rosen, E.M., & Fan, S. (2012). Sanguinarine inhibits growth of human cervical cancer cells through the induction of apoptosis. Oncology Reports, 28, 2264-2270. https://doi.org/10.3892/or.2012.2024
MLA
Xu, J., Meng, Q., Chong, Y., Jiao, Y., Zhao, L., Rosen, E. M., Fan, S."Sanguinarine inhibits growth of human cervical cancer cells through the induction of apoptosis". Oncology Reports 28.6 (2012): 2264-2270.
Chicago
Xu, J., Meng, Q., Chong, Y., Jiao, Y., Zhao, L., Rosen, E. M., Fan, S."Sanguinarine inhibits growth of human cervical cancer cells through the induction of apoptosis". Oncology Reports 28, no. 6 (2012): 2264-2270. https://doi.org/10.3892/or.2012.2024
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