Let-7a inhibits proliferation and induces apoptosis by targeting EZH2 in nasopharyngeal carcinoma cells

  • Authors:
    • Kemin Cai
    • Yi Wan
    • Guan Sun
    • Lei Shi
    • Xueli Bao
    • Zhimin Wang
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  • Published online on: September 12, 2012     https://doi.org/10.3892/or.2012.2027
  • Pages: 2101-2106
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Abstract

Let-7a is frequently downregulated in various types of human cancer including nasopharyngeal carcinoma. However, the underlying mechanism of let-7a action in nasopharyngeal carcinoma remains elusive. In this study, we show that the enhancer of zeste homolog 2 (EZH2) is a direct target of let-7a in human nasopharyngeal carcinoma cells. The inhibition of EZH2 in vitro by let-7a, EZH2 siRNA, attenuated nasopharyngeal carcinoma cell growth, inhibited cell proliferation and induced cell apoptosis. In addition, for each biological process we identified ontology-associated transcripts that significantly correlate with EZH2 expression. Finally, the expression of EZH2 significantly abrogated let-7a-mediated cell proliferation and apoptosis in the nasopharyngeal carcinoma cells. Taken together, our results suggest that let-7a and EZH2 may be potential therapeutic targets for nasopharyngeal carcinoma.
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December 2012
Volume 28 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Cai K, Wan Y, Sun G, Shi L, Bao X and Wang Z: Let-7a inhibits proliferation and induces apoptosis by targeting EZH2 in nasopharyngeal carcinoma cells. Oncol Rep 28: 2101-2106, 2012.
APA
Cai, K., Wan, Y., Sun, G., Shi, L., Bao, X., & Wang, Z. (2012). Let-7a inhibits proliferation and induces apoptosis by targeting EZH2 in nasopharyngeal carcinoma cells. Oncology Reports, 28, 2101-2106. https://doi.org/10.3892/or.2012.2027
MLA
Cai, K., Wan, Y., Sun, G., Shi, L., Bao, X., Wang, Z."Let-7a inhibits proliferation and induces apoptosis by targeting EZH2 in nasopharyngeal carcinoma cells". Oncology Reports 28.6 (2012): 2101-2106.
Chicago
Cai, K., Wan, Y., Sun, G., Shi, L., Bao, X., Wang, Z."Let-7a inhibits proliferation and induces apoptosis by targeting EZH2 in nasopharyngeal carcinoma cells". Oncology Reports 28, no. 6 (2012): 2101-2106. https://doi.org/10.3892/or.2012.2027