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December 2012 Volume 28 Issue 6

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Article

Let-7a inhibits proliferation and induces apoptosis by targeting EZH2 in nasopharyngeal carcinoma cells

  • Authors:
    • Kemin Cai
    • Yi Wan
    • Guan Sun
    • Lei Shi
    • Xueli Bao
    • Zhimin Wang
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology Head and Neck Surgery, Taizhou People's Hospital, Taizhou 225300, Jiangsu, P.R. China, Department of Neurosurgery, Suzhou Kowloon Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Suzhou 215021, P.R. China, Department of Neurosurgery, Fourth Affiliated Yancheng Hospital of Nantong University, Yancheng 224000, P.R. China, Department of Neurosurgery, The First People's Hospital of Kunshan affiliated with Jiangsu University, Suzhou 215300, P.R. China
  • Pages: 2101-2106
    |
    Published online on: September 12, 2012
       https://doi.org/10.3892/or.2012.2027
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Abstract

Let-7a is frequently downregulated in various types of human cancer including nasopharyngeal carcinoma. However, the underlying mechanism of let-7a action in nasopharyngeal carcinoma remains elusive. In this study, we show that the enhancer of zeste homolog 2 (EZH2) is a direct target of let-7a in human nasopharyngeal carcinoma cells. The inhibition of EZH2 in vitro by let-7a, EZH2 siRNA, attenuated nasopharyngeal carcinoma cell growth, inhibited cell proliferation and induced cell apoptosis. In addition, for each biological process we identified ontology-associated transcripts that significantly correlate with EZH2 expression. Finally, the expression of EZH2 significantly abrogated let-7a-mediated cell proliferation and apoptosis in the nasopharyngeal carcinoma cells. Taken together, our results suggest that let-7a and EZH2 may be potential therapeutic targets for nasopharyngeal carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Cai K, Wan Y, Sun G, Shi L, Bao X and Wang Z: Let-7a inhibits proliferation and induces apoptosis by targeting EZH2 in nasopharyngeal carcinoma cells. Oncol Rep 28: 2101-2106, 2012.
APA
Cai, K., Wan, Y., Sun, G., Shi, L., Bao, X., & Wang, Z. (2012). Let-7a inhibits proliferation and induces apoptosis by targeting EZH2 in nasopharyngeal carcinoma cells. Oncology Reports, 28, 2101-2106. https://doi.org/10.3892/or.2012.2027
MLA
Cai, K., Wan, Y., Sun, G., Shi, L., Bao, X., Wang, Z."Let-7a inhibits proliferation and induces apoptosis by targeting EZH2 in nasopharyngeal carcinoma cells". Oncology Reports 28.6 (2012): 2101-2106.
Chicago
Cai, K., Wan, Y., Sun, G., Shi, L., Bao, X., Wang, Z."Let-7a inhibits proliferation and induces apoptosis by targeting EZH2 in nasopharyngeal carcinoma cells". Oncology Reports 28, no. 6 (2012): 2101-2106. https://doi.org/10.3892/or.2012.2027
Copy and paste a formatted citation
x
Spandidos Publications style
Cai K, Wan Y, Sun G, Shi L, Bao X and Wang Z: Let-7a inhibits proliferation and induces apoptosis by targeting EZH2 in nasopharyngeal carcinoma cells. Oncol Rep 28: 2101-2106, 2012.
APA
Cai, K., Wan, Y., Sun, G., Shi, L., Bao, X., & Wang, Z. (2012). Let-7a inhibits proliferation and induces apoptosis by targeting EZH2 in nasopharyngeal carcinoma cells. Oncology Reports, 28, 2101-2106. https://doi.org/10.3892/or.2012.2027
MLA
Cai, K., Wan, Y., Sun, G., Shi, L., Bao, X., Wang, Z."Let-7a inhibits proliferation and induces apoptosis by targeting EZH2 in nasopharyngeal carcinoma cells". Oncology Reports 28.6 (2012): 2101-2106.
Chicago
Cai, K., Wan, Y., Sun, G., Shi, L., Bao, X., Wang, Z."Let-7a inhibits proliferation and induces apoptosis by targeting EZH2 in nasopharyngeal carcinoma cells". Oncology Reports 28, no. 6 (2012): 2101-2106. https://doi.org/10.3892/or.2012.2027
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