Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
December 2012 Volume 28 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December 2012 Volume 28 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

LOH 19q indicates shorter disease progression-free interval in low-grade oligodendrogliomas with EMP3 methylation

  • Authors:
    • Alice Pasini
    • Paolo Iorio
    • Emanuela Bianchi
    • Serenella Cerasoli
    • Anna M. Cremonini
    • Marina Faedi
    • Carlo Guarnieri
    • Graziano Guiducci
    • Luca Riccioni
    • Chiara Molinari
    • Claudia Rengucci
    • Daniele Calistri
    • Emanuele Giordano
  • View Affiliations / Copyright

    Affiliations: Laboratory of Cellular and Molecular Engineering ‘S. Cavalcanti’, University of Bologna, Cesena, Italy, Gruppo Neuroncologico Romagnolo (GNR), Cesena, Italy, Department of Biochemistry ‘G. Moruzzi’, University of Bologna, Bologna, Italy, IRCCS Romagnolo Scientific Institute for the Study and Treatment of Cancer (IRST), Meldola, Italy
  • Pages: 2271-2277
    |
    Published online on: September 20, 2012
       https://doi.org/10.3892/or.2012.2047
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

We previously described a cohort of grade II oligodendroglioma (OII) patients, in whom the loss of heterozygosity (LOH) 19q was present in the subgroup at a higher risk of relapse. In this study, we evaluated the CpG methylation of the putative tumor suppressor epithelial membrane protein 3 (EMP3, 19q13.3) gene promoter in the same OII cohort, to investigate whether a correlation could be found between EMP3 cytogenetic and epigenetic loss and higher risk of relapse. Twenty-three tumor samples from OII patients were collected over a period of 10 years. Seventeen glioblastoma (GBM) samples (2 of which were relapses) were collected from 15 patients. The EMP3, O6-methylguanine methyltransferase (MGMT) and cyclooxygenase 2 (COX2) promoter methylation, evaluated by methylation-specific PCR, and the isocitrate dehydrogenase 1 (IDH1) mutation, identified by sequencing, were compared between the OII and GBM histotypes. The EMP3 promoter methylation was correlated with the analysis of LOH 19q, performed by microsatellite amplification, in OII patients. Disease progression-free interval was evaluated in the OII patients with the EMP3 methylation with either LOH 19q or conserved chromosome 19 arms. The EMP3 and MGMT promoter methylation was more frequent in OII than in GBM patients, and the IDH1 mutation was absent in GBM. The COX2 promoter was unmethylated in both histotypes. Both LOH+/- 19q OII patients showed EMP3 hypermethylation. Concomitant LOH 19q and EMP3 gene promoter methylation was observed in the OII patients at a higher risk of relapse. Our results suggest that a total (cytogenetic and epigenetic) functional loss of both EMP3 alleles accounts for the reduced disease progression-free interval in OII patients. Although the small sample size limits the strength of this study, our results support testing this hypothesis in larger cohorts of patients, considering the methylation of the EMP3 gene promoter together with LOH 19q as an indication for treatment with adjuvant therapy ab initio in order to improve the overall survival of OII patients.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, et al: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 114:97–109. 2007. View Article : Google Scholar : PubMed/NCBI

2 

El-Hateer H, Souhami L, Roberge D, Maestro RD, Leblanc R, Eldebawy, et al: Low-grade oligodendroglioma: an indolent but incurable disease? J Neurosurg. 111:265–271. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Mason WP: Oligodendroglioma. Curr Treat Options Neurol. 7:305–314. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Shaw EG, Berkey B, Coons SW, Bullard D, Brachman D, Buckner JC, et al: Recurrence following neurosurgeon-determined gross-total resection of adult supratentorial low-grade glioma: results of a prospective clinical trial. J Neurosurg. 109:835–841. 2008. View Article : Google Scholar

5 

Pignatti F, van den Bent M, Curran D, Debruyne C, Sylvester R, Therasse P, Afra D, Cornu P, Bolla M, Vecht C and Karim AB; European Organization for Research and Treatment of Cancer Brain Tumor Cooperative Group; European Organization for Research and Treatment of Cancer Radiotherapy Cooperative Group. Prognostic factors for survival in adult patients with cerebral low-grade glioma. J Clin Oncol. 20:2076–2084. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Jenkins RB, Blair H, Ballman KV, Giannini C, Arusell RM, Law M, et al: At(1;19)(q10;p10) mediates the combined deletions of 1p and 19q and predicts a better prognosis of patients with oligodendroglioma. Cancer Res. 66:9852–9861. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Felsberg J, Erkwoh A, Sabel MC, Kirsch L, Fimmers R, Blaschke B, et al: Oligodendroglial tumours: refinement of candidate regions on chromosome arm 1p and correlation of 1p/19q status with survival. Brain Pathol. 14:121–130. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Okamoto Y, Di Patre PL, Burkhard C, Horstmann S, Jourde B, Fahey M, et al: Population-based study on incidence, survival rates, and genetic alterations of low-grade diffuse astrocytomas and oligodendrogliomas. Acta Neuropathol. 108:49–56. 2004. View Article : Google Scholar

9 

van den Bent MJ, Looijenga LH, Langenberg K, Dinjens W, Graveland W, Uytdewilligen L, et al: Chromosomal anomalies in oligodendroglial tumours are correlated with clinical features. Cancer. 97:1276–1284. 2003.PubMed/NCBI

10 

Natsume A, Kondo Y, Ito M, Motomura K, Wakabayashi T and Yoshida J: Epigenetic aberrations and therapeutic implications in gliomas. Cancer Sci. 101:1331–1336. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Esteller M, Hamilton SR, Burger PC, Baylin SB and Herman JG: Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res. 59:793–797. 1999.PubMed/NCBI

12 

Esteller M, Garcia-Foncillas J, Andion E, Goodman SN, Hidalgo OF, Vanaclocha V, et al: Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med. 343:1350–1354. 2000. View Article : Google Scholar

13 

Hegi ME, Diserens AC, Gorlia T, Hamou MF, de Tribolet N, Weller M, et al: MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med. 352:997–1003. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Alaminos M, Dávalos V, Ropero S, Setién F, Paz MF, Herranz M, et al: EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumour suppressor in glioma and neuroblastoma. Cancer Res. 65:2565–2571. 2005. View Article : Google Scholar

15 

Fumoto S, Tanimoto K, Hiyama E, Noguchi T, Nishiyama M and Hiyama K: EMP3 as a candidate tumor suppressor gene for solid tumors. Expert Opin Ther Targets. 13:811–822. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Qu M, Jiao H, Zhao J, Ren ZP, Smits A, Kere J and Nistér M: Molecular genetic and epigenetic analysis of NCX2/SLC8A2 at 19q13.3 in human gliomas. Neuropathol Appl Neurobiol. 36:198–210. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Taylor V and Suter U: Epithelial membrane protein-2 and epithelial membrane protein-3: two novel members of the peripheral myelin protein 22 gene family. Gene. 175:115–120. 1996. View Article : Google Scholar : PubMed/NCBI

18 

Tews B, Felsberg J, Hartmann C, Kunitz A, Hahn M, Toedt G, et al: Identification of novel oligodendroglioma-associated candidate tumour suppressor genes in 1p36 and 19q13 using microarray-based expression profiling. Int J Cancer. 119:792–800. 2006. View Article : Google Scholar

19 

Yim JH, Kim YJ, Ko JH, Cho YE, Kim SM, Kim JY, et al: The putative tumour suppressor gene GLTSCR2 induces PTEN-modulated cell death. Cell Death Differ. 14:1872–1879. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Li KK, Pang JC, Chung NY, Ng YL, Chan NH, Zhou L, et al: EMP3 overexpression is associated with oligodendroglial tumours retaining chromosome arms 1p and 19q. Int J Cancer. 120:947–950. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Kunitz A, Wolter M, van den Boom J, Felsberg J, Tews B, Hahn M, et al: DNA hypermethylation and aberrant expression of the EMP3 gene at 19q13.3 in human gliomas. Brain Pathol. 17:363–370. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Molinari C, Iorio P, Medri L, Ballardini M, Guiducci G, Cremonini AM, et al: Chromosome 1p and 19q evaluation in low-grade oligodendrogliomas: A descriptive study. Int J Mol Med. 25:145–151. 2010.PubMed/NCBI

23 

Brandes AA, Tosoni A, Cavallo G, Reni M, Franceschi E, Bonaldi L, et al: Correlations between O6-methylguanine DNA methyltransferase promoter methylation status, 1p and 19q deletions, and response to temozolomide in anaplastic and recurrent oligodendroglioma: a prospective GICNO study. J Clin Oncol. 24:4746–4753. 2006.PubMed/NCBI

24 

Ichimura K, Pearson DM, Kocialkowski S, Bäcklund LM, Chan R, Jones DT and Collins VP: IDH1 mutations are present in the majority of common adult gliomas but are rare in primary glioblastomas. Neuro Oncol. 11:341–347. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Herman JG, Graff JR, Myöhänen S, Nelkin BD and Baylin SB: Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA. 93:9821–9826. 1996. View Article : Google Scholar : PubMed/NCBI

26 

Giannini C, Burger PC, Berkey BA, Cairncross JG, Jenkins RB, Mehta M, et al: Anaplastic oligodendroglial tumours: refining the correlation among histopathology, 1p 19q deletion and clinical outcome in Intergroup Radiation Therapy Oncology Group Trial 9402. Brain Pathol. 18:360–369. 2008. View Article : Google Scholar

27 

Bello MJ, Leone PE, Vaquero J, de Campos JM, Kusak ME, Sarasa JL, et al: Allelic loss at 1p and 19q frequently occurs in association and may represent early oncogenic events in oligodendroglial tumours. Int J Cancer. 64:207–210. 1995. View Article : Google Scholar : PubMed/NCBI

28 

Smith JS, Alderete B, Minn Y, Borell TJ, Perry A, Mohapatra G, et al: Localization of common deletion regions on 1p and 19q in human gliomas and their association with histological subtype. Oncogene. 18:4144–4152. 1999. View Article : Google Scholar : PubMed/NCBI

29 

Kaneshiro D, Kobayashi T, Chao ST, Suh J and Prayson RA: Chromosome 1p and 19q deletions in glioblastoma multiforme. Appl Immunohistochem Mol Morphol. 17:512–516. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Nigro JM, Misra A, Zhang L, Smirnov I, Colman H, Griffin C, et al: Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma. Cancer Res. 65:1678–1686. 2005. View Article : Google Scholar

31 

Ruano Y, Mollejo M, Ribalta T, Fiaño C, Camacho FI, Gómez E, et al: Identification of novel candidate target genes in amplicons of Glioblastoma multiforme tumors detected by expression and CGH microarray profiling. Mol Cancer. 5:392006. View Article : Google Scholar : PubMed/NCBI

32 

Fumoto S, Hiyama K, Tanimoto K, Noguchi T, Hihara J, Hiyama E, et al: EMP3 as a tumor suppressor gene for esophageal squamous cell carcinoma. Cancer Lett. 274:25–32. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Pasini A, Iorio P, Bianchi E, Cerasoli S, Cremonini AM, Faedi M, Guarnieri C, Guiducci G, Riccioni L, Molinari C, Molinari C, et al: LOH 19q indicates shorter disease progression-free interval in low-grade oligodendrogliomas with EMP3 methylation. Oncol Rep 28: 2271-2277, 2012.
APA
Pasini, A., Iorio, P., Bianchi, E., Cerasoli, S., Cremonini, A.M., Faedi, M. ... Giordano, E. (2012). LOH 19q indicates shorter disease progression-free interval in low-grade oligodendrogliomas with EMP3 methylation. Oncology Reports, 28, 2271-2277. https://doi.org/10.3892/or.2012.2047
MLA
Pasini, A., Iorio, P., Bianchi, E., Cerasoli, S., Cremonini, A. M., Faedi, M., Guarnieri, C., Guiducci, G., Riccioni, L., Molinari, C., Rengucci, C., Calistri, D., Giordano, E."LOH 19q indicates shorter disease progression-free interval in low-grade oligodendrogliomas with EMP3 methylation". Oncology Reports 28.6 (2012): 2271-2277.
Chicago
Pasini, A., Iorio, P., Bianchi, E., Cerasoli, S., Cremonini, A. M., Faedi, M., Guarnieri, C., Guiducci, G., Riccioni, L., Molinari, C., Rengucci, C., Calistri, D., Giordano, E."LOH 19q indicates shorter disease progression-free interval in low-grade oligodendrogliomas with EMP3 methylation". Oncology Reports 28, no. 6 (2012): 2271-2277. https://doi.org/10.3892/or.2012.2047
Copy and paste a formatted citation
x
Spandidos Publications style
Pasini A, Iorio P, Bianchi E, Cerasoli S, Cremonini AM, Faedi M, Guarnieri C, Guiducci G, Riccioni L, Molinari C, Molinari C, et al: LOH 19q indicates shorter disease progression-free interval in low-grade oligodendrogliomas with EMP3 methylation. Oncol Rep 28: 2271-2277, 2012.
APA
Pasini, A., Iorio, P., Bianchi, E., Cerasoli, S., Cremonini, A.M., Faedi, M. ... Giordano, E. (2012). LOH 19q indicates shorter disease progression-free interval in low-grade oligodendrogliomas with EMP3 methylation. Oncology Reports, 28, 2271-2277. https://doi.org/10.3892/or.2012.2047
MLA
Pasini, A., Iorio, P., Bianchi, E., Cerasoli, S., Cremonini, A. M., Faedi, M., Guarnieri, C., Guiducci, G., Riccioni, L., Molinari, C., Rengucci, C., Calistri, D., Giordano, E."LOH 19q indicates shorter disease progression-free interval in low-grade oligodendrogliomas with EMP3 methylation". Oncology Reports 28.6 (2012): 2271-2277.
Chicago
Pasini, A., Iorio, P., Bianchi, E., Cerasoli, S., Cremonini, A. M., Faedi, M., Guarnieri, C., Guiducci, G., Riccioni, L., Molinari, C., Rengucci, C., Calistri, D., Giordano, E."LOH 19q indicates shorter disease progression-free interval in low-grade oligodendrogliomas with EMP3 methylation". Oncology Reports 28, no. 6 (2012): 2271-2277. https://doi.org/10.3892/or.2012.2047
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team