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Article

HMGB1 induces the overexpression of miR-222 and miR-221 and increases growth and motility in papillary thyroid cancer cells

  • Authors:
    • Stefania Mardente
    • Emanuela Mari
    • Fabrizio Consorti
    • Cira Di Gioia
    • Rodolfo Negri
    • Marilena Etna
    • Alessandra Zicari
    • Alfredo Antonaci
  • View Affiliations / Copyright

    Affiliations: Department of Experimental Medicine, Sapienza University of Rome, I-00161 Rome, Italy, Department of Surgery ‘F. Durante’, Sapienza University of Rome, I-00161 Rome, Italy, Department of Radiology, Oncology and Pathology, Sapienza University of Rome, I-00161 Rome, Italy, Department of Biology and Biotechnology ‘Charles Darwin’, Sapienza University of Rome, I-00161 Rome, Italy
  • Pages: 2285-2289
    |
    Published online on: September 26, 2012
       https://doi.org/10.3892/or.2012.2058
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Abstract

Experimental and epidemiological studies have revealed that chronic inflammation contributes to cancer progression and even predisposes to cellular transformation. Inflammatory infiltrates in papillary thyroid cancer include lymphocytes, macrophages and cytokines. High-mobility group box 1 protein (HMGB1) is a late inflammatory cytokine that signals danger to the immune system through the receptor for advanced glycation end-products (RAGE) and Toll-like receptor. The activation of the above receptors results in the secretion of growth, chemotactic and angiogenic factors that contribute to chronic inflammation. In this study, we suggest that apart from the activation of signal transduction pathways by the activation of RAGE, the indirect inhibition of cell cycle regulators [such as phosphatase and tensin homolog (PTEN)] may also cause an increase in cell growth and motility. MicroRNAs (miRNAs) have increasingly been implicated in regulating the malignant progression of cancer. MiR-221 and miR-222 have been found to be deregulated in human papillary thyroid carcinomas. They are involved in cell proliferation through the inhibition of the cell cycle regulator, p27kip1, in human papillary carcinomas. In this study, we show that HMGB1 increases the expression of miR-221 and miR-222 in primary cultures of excised papillary lesions and in an established papillary cancer cell line (BC PAP). The overexpression of oncogenic miR-221 and miR-222 caused by HMGB1 is associated with an increase in malignancy scores, namely cell growth and motility.
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Copy and paste a formatted citation
Spandidos Publications style
Mardente S, Mari E, Consorti F, Di Gioia C, Negri R, Etna M, Zicari A and Antonaci A: HMGB1 induces the overexpression of miR-222 and miR-221 and increases growth and motility in papillary thyroid cancer cells. Oncol Rep 28: 2285-2289, 2012.
APA
Mardente, S., Mari, E., Consorti, F., Di Gioia, C., Negri, R., Etna, M. ... Antonaci, A. (2012). HMGB1 induces the overexpression of miR-222 and miR-221 and increases growth and motility in papillary thyroid cancer cells. Oncology Reports, 28, 2285-2289. https://doi.org/10.3892/or.2012.2058
MLA
Mardente, S., Mari, E., Consorti, F., Di Gioia, C., Negri, R., Etna, M., Zicari, A., Antonaci, A."HMGB1 induces the overexpression of miR-222 and miR-221 and increases growth and motility in papillary thyroid cancer cells". Oncology Reports 28.6 (2012): 2285-2289.
Chicago
Mardente, S., Mari, E., Consorti, F., Di Gioia, C., Negri, R., Etna, M., Zicari, A., Antonaci, A."HMGB1 induces the overexpression of miR-222 and miR-221 and increases growth and motility in papillary thyroid cancer cells". Oncology Reports 28, no. 6 (2012): 2285-2289. https://doi.org/10.3892/or.2012.2058
Copy and paste a formatted citation
x
Spandidos Publications style
Mardente S, Mari E, Consorti F, Di Gioia C, Negri R, Etna M, Zicari A and Antonaci A: HMGB1 induces the overexpression of miR-222 and miR-221 and increases growth and motility in papillary thyroid cancer cells. Oncol Rep 28: 2285-2289, 2012.
APA
Mardente, S., Mari, E., Consorti, F., Di Gioia, C., Negri, R., Etna, M. ... Antonaci, A. (2012). HMGB1 induces the overexpression of miR-222 and miR-221 and increases growth and motility in papillary thyroid cancer cells. Oncology Reports, 28, 2285-2289. https://doi.org/10.3892/or.2012.2058
MLA
Mardente, S., Mari, E., Consorti, F., Di Gioia, C., Negri, R., Etna, M., Zicari, A., Antonaci, A."HMGB1 induces the overexpression of miR-222 and miR-221 and increases growth and motility in papillary thyroid cancer cells". Oncology Reports 28.6 (2012): 2285-2289.
Chicago
Mardente, S., Mari, E., Consorti, F., Di Gioia, C., Negri, R., Etna, M., Zicari, A., Antonaci, A."HMGB1 induces the overexpression of miR-222 and miR-221 and increases growth and motility in papillary thyroid cancer cells". Oncology Reports 28, no. 6 (2012): 2285-2289. https://doi.org/10.3892/or.2012.2058
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