microRNA-181a is associated with poor prognosis of colorectal cancer

  • Authors:
    • Junichi Nishimura
    • Rio Handa
    • Hirofumi Yamamoto
    • Fumiaki Tanaka
    • Kohei Shibata
    • Koshi Mimori
    • Ichiro Takemasa
    • Tsunekazu Mizushima
    • Masataka Ikeda
    • Mitsugu Sekimoto
    • Hideshi Ishii
    • Yuichiro Doki
    • Masaki Mori
  • View Affiliations

  • Published online on: September 26, 2012     https://doi.org/10.3892/or.2012.2059
  • Pages: 2221-2226
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Abstract

miRNAs regulate gene expression at the post-transcriptional level by degradation of mRNA and translational repression. Recent studies have shown that miR-181a is dysregulated in several types of cancer; however, the clinical significance of miR‑181a in colorectal cancer (CRC) remains unclear. We addressed this question by using quantitative real-time PCR (qRT-PCR) to analyze miR-181a expression in 162 CRC patients. There was no significant difference in miR-181a expression in normal colon vs. colorectal cancer tissue. The cancer tissue samples were categorized into a low and high expression group based on miR-181a expression. Comparison of the clinicopathological factors and prognosis in these two groups showed that the high expression group had a significantly poorer prognosis than the low expression group (P=0.011). Multivariate analysis indicated that high miR-181a expression was an independent significant prognostic factor for CRC. However, there no correlation was observed between miR-181a expression and clinicopathological parameters. In vitro analysis revealed that the overexpression of miR-181a repressed the expression of the tumor suppressor, phosphatase and tensin homolog (PTEN) located on chromosome 10, at the mRNA level. These data suggest that miR-181a may be a new independent prognostic factor for CRC patients.
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December 2012
Volume 28 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Nishimura J, Handa R, Yamamoto H, Tanaka F, Shibata K, Mimori K, Takemasa I, Mizushima T, Ikeda M, Sekimoto M, Sekimoto M, et al: microRNA-181a is associated with poor prognosis of colorectal cancer. Oncol Rep 28: 2221-2226, 2012.
APA
Nishimura, J., Handa, R., Yamamoto, H., Tanaka, F., Shibata, K., Mimori, K. ... Mori, M. (2012). microRNA-181a is associated with poor prognosis of colorectal cancer. Oncology Reports, 28, 2221-2226. https://doi.org/10.3892/or.2012.2059
MLA
Nishimura, J., Handa, R., Yamamoto, H., Tanaka, F., Shibata, K., Mimori, K., Takemasa, I., Mizushima, T., Ikeda, M., Sekimoto, M., Ishii, H., Doki, Y., Mori, M."microRNA-181a is associated with poor prognosis of colorectal cancer". Oncology Reports 28.6 (2012): 2221-2226.
Chicago
Nishimura, J., Handa, R., Yamamoto, H., Tanaka, F., Shibata, K., Mimori, K., Takemasa, I., Mizushima, T., Ikeda, M., Sekimoto, M., Ishii, H., Doki, Y., Mori, M."microRNA-181a is associated with poor prognosis of colorectal cancer". Oncology Reports 28, no. 6 (2012): 2221-2226. https://doi.org/10.3892/or.2012.2059