Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
December 2012 Volume 28 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December 2012 Volume 28 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

The effect of G-CSF on F-actin reorganization in HL-60 and K562 cell lines

  • Authors:
    • Magdalena Izdebska
    • Dariusz Grzanka
    • Maciej Gagat
    • Lidia Gackowska
    • Alina Grzanka
  • View Affiliations / Copyright

    Affiliations: Department of Histology and Embryology, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, 85-092 Bydgoszcz, Poland, Department of Clinical Pathomorphology, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, 85-092 Bydgoszcz, Poland, Department of Immunology, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, 85-092 Bydgoszcz, Poland
  • Pages: 2138-2148
    |
    Published online on: September 26, 2012
       https://doi.org/10.3892/or.2012.2061
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of this investigation was to show the influence of G-CSF (G-CSF) on the F-actin cytoskeleton and the morphology of G-CSFR-proficient HL-60 and G-CSFR-deficient K562 cell lines. In the present study, we show changes in F-actin distribution in HL-60 cells after treatment with 5 and 10 ng/ml concentration of G-CSF but also changes in the organization and fluorescence intensity of F-actin in the K562 cell line. After treatment of HL-60 cells with 5 ng/ml concentration of G-CSF we observed an increase in F-actin levels. Additionally, a higher labeling of nuclear F-actin under TEM was observed. Moreover, changes in the cell cycle indicate cell differentiation. On the other hand, in the K562 cell line we observed an increase in the percentage sub-G1 cells following treatment with both concentration of G-CSF. Furthermore, an increase in the percentage of late apoptotic cells after G-CSF treatment was observed. A statistically significant difference in the cytoplasmic F-actin levels was not detected, but nuclear levels were decreased. In conclusion, we suggest that the G-CSF-based reorganization of actin filaments in HL-60 cells is involved in the differentiation process. Moreover, we suggest that the G-CSF-induced changes observed in K562 cells are associated with a G-CSF receptor-independent pathway or its binding to other similar receptors.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

Figure 11

View References

1 

Oppenheim JJ: Cytokines: past, present and future. Int J Hematol. 74:3–8. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Basu S, Dunn A and Ward A: G-CSF: function and modes of action. Int J Mol Med. 10:3–10. 2002.PubMed/NCBI

3 

Beekman R and Touw IP: G-CSF and its receptor in myeloid malignancy. Blood. 115:5131–5136. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Franzke A: The role of G-CSF in adaptive immunity. Cytokine Growth Factor Rev. 17:235–244. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Leavey PJ, Sellins KS, Thurman G, et al: In vivo treatment with granulocyte colony-stimulating factor results in divergent effects on neutrophil functions measured in vitro. Blood. 92:4366–4374. 1998.PubMed/NCBI

6 

Suzuki S, Kobayashi M, Chiba K, et al: Autocrine production of epithelial cell-derived neutrophil attractant-78 induced by granulocyte colony-stimulating factor in neutrophils. Blood. 99:1863–1865. 2002.PubMed/NCBI

7 

Bradstock KF: The use of hematopoietic growth factors in the treatment of acute leukemia. Curr Pharm Des. 8:343–355. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Carulli G, Mattii L, Azzara A, et al: Actin polymerization in neutrophils from donors of peripheral blood stem cells: divergent effects of glycosylated and nonglycosylated recombinant human granulocyte colony-stimulating factor. Am J Hematol. 81:318–323. 2006. View Article : Google Scholar

9 

Håkansson L, Höglund M, Jönsson UB, Torsteinsdottir I, Xu X and Venge P: Effects of in vivo administration of G-CSF on neutrophil and eosinophil adhesion. Br J Haematol. 98:603–611. 1997.PubMed/NCBI

10 

Ripa RS and Kastrup J: G-CSF therapy with mobilization of bone marrow stem cells for myocardial recovery after acute myocardial infarction - a relevant treatment? Exp Hematol. 36:681–686. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Ku NO, Zhou X, Toivola DM and Omary MB: The cytoskeleton of digestive epithelia in health and disease. Am J Physiol. 277:G1108–G1137. 1999.PubMed/NCBI

12 

Bursch W, Hochegger K, Torok L, Marian B, Ellinger A and Hermann RS: Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments. J Cell Sci. 113:1189–1198. 2000.PubMed/NCBI

13 

Pollard TD: The cytoskeleton, cellular motility and the reductionist agenda. Nature. 422:741–745. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Ndozangue-Touriguine O, Hamelin J and Bréard J: Cytoskeleton and apoptosis. Biochem Pharmacol. 76:11–18. 2008. View Article : Google Scholar

15 

Hightower RC and Meagher RB: The molecular evolution of actin. Genetics. 114:315–332. 1986.PubMed/NCBI

16 

Akisaka T, Yoshida H, Inoue S and Shimizu K: Organization of cytoskeletal F-actin, G-actin, and gelsolin in the adhesion structures in cultured osteoclast. J Bone Miner Res. 16:1248–1255. 2001. View Article : Google Scholar : PubMed/NCBI

17 

White S, Williams P, Wojcik KR, Sun S, Hiemstra PS, Rabe KF and Dorscheid DR: Initiation of apoptosis by actin cytoskeletal derangement in human airway epithelial cells. Am J Respir Cell Mol Biol. 24:282–294. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Ascough KR: Endocytosis: Actin in the driving seat. Curr Biol. 14:R124–R126. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Carlier MF and Pantaloni D: Control of actin assembly dynamics in cell motility. J Biol Chem. 282:23005–23009. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Pederson T and Aebi U: Actin in the nucleus: what form and what for? J Struct Biol. 140:3–9. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Visa N and Percipalle P: Nuclear functions of actin. Cold Spring Harb Perspect Biol. 2:a0006202010. View Article : Google Scholar : PubMed/NCBI

22 

Olave IA, Reck-Peterson SL and Crabtree GR: Nuclear actin and actin-related proteins in chromatin remodeling. Annu Rev Biochem. 71:755–781. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Blessing CA, Ugrinova GT and Goodson HV: Actin and ARPs: action in the nucleus. Trends Cell Biol. 14:435–442. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Hofmann WA, Stojiljkovic L, Fuchsova B, et al: Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II. Nat Cell Biol. 6:1094–1101. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Miralles F and Visa N: Actin in transcription and transcription regulation. Curr Opin Cell Biol. 18:261–266. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Chen M and Shen X: Nuclear actin and actin-related proteins in chromatin dynamics. Curr Opin Cell Biol. 19:326–330. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Pederson T: As functional nuclear actin comes into view, is it globular, filamentous, or both? J Cell Biol. 180:1061–1064. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Gieni RS and Hendzel MJ: Actin dynamics and functions in the interphase nucleus: moving toward an understanding of nuclear polymeric actin. Biochem Cell Biol. 87:283–306. 2009.PubMed/NCBI

29 

Xu YZ, Thuraisingam T, Morais DA, Rola-Pleszczynski M and Radzioch D: Nuclear translocation of β-actin is involved in transcriptional regulation during macrophage differentiation of HL-60 cells. Mol Biol Cell. 21:811–820. 2010.

30 

Kutsuna H, Suzuki K, Kamata N, et al: Actin reorganization and morphological changes in human neutrophils stimulated by TNF, GM-CSF and G-CSF: the role of MAP kinases. Am J Physiol Cell Physiol. 286:55–64. 2004. View Article : Google Scholar : PubMed/NCBI

31 

El-Sonbaty SS, Watanabe M, Hochito K, Yamaguchi K, Matsuda I and Tsuchiya H: Exogenously expressed granulocyte colony-stimulating factor (G-CSF) receptor on K562 cells can transduce G-CSF-triggered growth and differentiation signals. Int J Hematol. 61:61–68. 1995. View Article : Google Scholar

32 

Saito K, Nakamura Y, Waga K, et al: Mature and immature myeloid cells decrease the granulocyte colony-stimulating factor level by absorption of granulocyte colony-stimulating factor. Int J Hematol. 67:145–151. 1998. View Article : Google Scholar : PubMed/NCBI

33 

Brandstetter T, Ninci E, Bettendorf H, et al: Granulocyte colony stimulating factor (G-CSF) receptor gene expression of ovarian carcinoma does not correlate with G-CSF caused cell proliferation. Cancer. 91:1372–1383. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Veselska R, Zitterbart K, Jelinkova S, Neradil J and Svoboda A: Specific cytoskeleton changes during apoptosis accompanying induced differentiation of HL-60 myeloid leukemia cells. Oncol Rep. 10:1049–1058. 2003.

35 

Godyn JJ, Xu H, Zhang F, Kolla S and Studzinski GP: A dual block to cell cycle progression in HL60 cells exposed to analogues of vitamin D3. Cell Prolif. 27:37–46. 1994. View Article : Google Scholar : PubMed/NCBI

36 

Erenpreisa J and Cragg MS: Mitotic death: a mechanism of survival? Cancer Cell Int. 1:12001. View Article : Google Scholar

37 

Zitterbart K and Veselska R: Effect of retinoic acid on the actin cytoskeleton in HL-60 cells. Neoplasma. 48:456–461. 2001.PubMed/NCBI

38 

Grzanka A, Grzanka D and Orlikowska M: Cytoskeletal reorganization during process of apoptosis induced by cytostatic drugs in K-562 and HL-60 leukemia cell lines. Biochem Pharmacol. 66:1611–1617. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Atencia R, Garcia-Sanz M, Perez-Yarza G, Asumendi A, Hilario E and Arechaga J: A structural analysis of cytoskeleton components during the execution chase of apoptosis. Protoplasma. 198:163–169. 1997. View Article : Google Scholar

40 

Brown SB, Bailey K and Savill J: Actin is cleaved during constitutive apoptosis. Biochem J. 323:233–237. 1997.PubMed/NCBI

41 

Grzanka A, Izdebska M, Litwiniec A, Grzanka D and Safiejko-Mroczka B: Actin filament reorganization in HL-60 leukemia cell line after treatment with G-CSF and GM-CSF. Folia Histochem Cytobiol. 45:191–197. 2007.PubMed/NCBI

42 

Chodniewicz D and Zhelev DV: Novel pathway of F-actin polymerization in the human neutrophil. Blood. 102:2251–2258. 2003. View Article : Google Scholar : PubMed/NCBI

43 

Gomez-Cambronero J, Horn J, Paul CC and Baumann MA: Granulocyte-macrophage colony-stimulating factor is a chemoattractant cytokine for human neutrophils: involvement of the ribosomal p70 S6 kinase signaling pathway. J Immunol. 171:6846–6855. 2003. View Article : Google Scholar

44 

Mailänder V and Landfester K: Interaction of nanoparticles with cells. Biomacromolecules. 10:2379–2400. 2009.

45 

Izdebska M, Grzanka D, Gackowska L, Żuryń A and Grzanka A: The influence of Trisenox on action organization in HL-60 cells. Cent Eur J Biol. 4:351–361. 2009. View Article : Google Scholar

46 

Grzanka D, Marszałek A, Gagat M, Izdebska M, Gackowska L and Grzanka A: Doxorubicin-induced F-actin reorganization in cofilin-1 (nonmuscle) down-regulated CHO AA8 cells. Folia Histochem Cytobiol. 48:377–386. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Izdebska M, Grzanka A, Ostrowski M, Żuryń A and Grzanka D: Effect of arsenic trioxide (Trisenox) on actin organization in K-562 erythroleukemia cells. Folia Histochem Cytobiol. 47:453–459. 2009.PubMed/NCBI

48 

Zhao K, Wang W, Rando OJ, Xue Y, Swiderek K, Kuo A and Crabtree GR: Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell. 95:625–636. 1998. View Article : Google Scholar : PubMed/NCBI

49 

Widlak P, Palyvoda O, Kumala S and Garrard WT: Modeling apoptotic chromatin condensation in normal cell nuclei. Requirement for intranuclear mobility and actin involvement. J Biol Chem. 277:21683–21690. 2002. View Article : Google Scholar : PubMed/NCBI

50 

Sjolinder M, Bjork P, Soderberg E, Sabri N, Farrants AK and Visa N: The growing pre-mRNA recruits actin and chromatin-modifying factors to transcriptionally active genes. Genes Dev. 19:1871–1884. 2005. View Article : Google Scholar : PubMed/NCBI

51 

Zhu QS, Xia L, Mills GB, Lowell CA, Touw IP and Corey SJ: G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth. Blood. 107:1847–1856. 2006. View Article : Google Scholar : PubMed/NCBI

52 

Kitagawa J, Hara T, Tsurumi H, Kanemura N, Kasahara S, Shimizu M and Moriwaki H: Cell cycle-dependent priming action of granulocyte colony-stimulating factor (G-CSF) enhances in vitro apoptosis induction by cytarabine and etoposide in leukemia cell lines. J Clin Exp Hematop. 50:99–105. 2010. View Article : Google Scholar

53 

Chow DC, Brevnova L, He XL, Martick MM, Bankovich A and Garcia KC: A structural template for gp130-cytokine signaling assemblies. Biochim Biophys Acta. 1592:225–235. 2002. View Article : Google Scholar : PubMed/NCBI

54 

Gearing DP, Thut CJ, VandeBos T, et al: Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J. 10:2839–2848. 1991.PubMed/NCBI

55 

Tartaglia LA, Dembski M, Weng X, et al: Identification and expression cloning of a leptin receptor, OB-R. Cell. 83:1263–1271. 1995. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Izdebska M, Grzanka D, Gagat M, Gackowska L and Grzanka A: The effect of G-CSF on F-actin reorganization in HL-60 and K562 cell lines. Oncol Rep 28: 2138-2148, 2012.
APA
Izdebska, M., Grzanka, D., Gagat, M., Gackowska, L., & Grzanka, A. (2012). The effect of G-CSF on F-actin reorganization in HL-60 and K562 cell lines. Oncology Reports, 28, 2138-2148. https://doi.org/10.3892/or.2012.2061
MLA
Izdebska, M., Grzanka, D., Gagat, M., Gackowska, L., Grzanka, A."The effect of G-CSF on F-actin reorganization in HL-60 and K562 cell lines". Oncology Reports 28.6 (2012): 2138-2148.
Chicago
Izdebska, M., Grzanka, D., Gagat, M., Gackowska, L., Grzanka, A."The effect of G-CSF on F-actin reorganization in HL-60 and K562 cell lines". Oncology Reports 28, no. 6 (2012): 2138-2148. https://doi.org/10.3892/or.2012.2061
Copy and paste a formatted citation
x
Spandidos Publications style
Izdebska M, Grzanka D, Gagat M, Gackowska L and Grzanka A: The effect of G-CSF on F-actin reorganization in HL-60 and K562 cell lines. Oncol Rep 28: 2138-2148, 2012.
APA
Izdebska, M., Grzanka, D., Gagat, M., Gackowska, L., & Grzanka, A. (2012). The effect of G-CSF on F-actin reorganization in HL-60 and K562 cell lines. Oncology Reports, 28, 2138-2148. https://doi.org/10.3892/or.2012.2061
MLA
Izdebska, M., Grzanka, D., Gagat, M., Gackowska, L., Grzanka, A."The effect of G-CSF on F-actin reorganization in HL-60 and K562 cell lines". Oncology Reports 28.6 (2012): 2138-2148.
Chicago
Izdebska, M., Grzanka, D., Gagat, M., Gackowska, L., Grzanka, A."The effect of G-CSF on F-actin reorganization in HL-60 and K562 cell lines". Oncology Reports 28, no. 6 (2012): 2138-2148. https://doi.org/10.3892/or.2012.2061
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team