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Article

Endocrine gland-derived vascular endothelial growth factor strengthens cell invasion ability via prokineticin receptor 2 in colon cancer cell lines

  • Authors:
    • Shinsuke Tabata
    • Takanori Goi
    • Toshiyuki Nakazawa
    • Youhei Kimura
    • Kanji Katayama
    • Akio Yamaguchi
  • View Affiliations / Copyright

    Affiliations: First Department of Surgery, University of Fukui, Yoshida-gun, Fukui, Japan
  • Pages: 459-463
    |
    Published online on: November 6, 2012
       https://doi.org/10.3892/or.2012.2124
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Abstract

Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) has recently been identified as one of the vascular endothelial growth factors, and it is considered that the overexpression of EG-VEGF in colon cancer is related to hepatic metastasis. In this study, we report our recent novel findings of the involvement of EG-VEGF in cell invasion of colon cancer cells. Colon cancer cell lines (DLD-1 and HCT116) with high expression of prokineticin receptor (PK-R) 1 and 2 were stimulated with the EG-VEGF protein. Furthermore, Matrigel cell invasion assay was performed to examine the changes in cancer cell invasion. In addition, we investigated the mRNA expression of matrix metalloproteinase (MMP)-2, -7 and -9 in cancer cells. Finally, the EG-VEGF receptor on the colon cancer cell membrane was blocked by anti-PK-R1 and -PK-R2 antibodies to study whether cell invasion ability would be altered. In colon cancer cell lines where the expression of PK-R1 and 2 was confirmed, stimulation with EG-VEGF increased cell invasion a maximum of ~3-5 times. Furthermore, an increase in the mRNA and protein expression of MMP-2, -7 and -9 was observed. We also observed that the cell invasion rate decreased only after exposure to the anti-PK-R2 antibody. The study showed that the EG-VEGF protein may act on MMP-2, -7 and -9 via PK-R2 to strengthen cell invasion ability in colon cancer cell lines.
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1 

Muto T, Kotake K and Koyama Y: Colorectal cancer statistics in Japan: data from JSCCR registration, 1974–1993. Int J Clin Oncol. 6:171–176. 2001.PubMed/NCBI

2 

Koyama Y and Kotake K: Overview of colorectal cancer in Japan: report from the Registry of the Japanese Society for Cancer of the Colon and Rectum. Dis Colon Rectum. 40:2–9. 1997. View Article : Google Scholar

3 

Fidler IJ and Ellis LM: The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell. 79:185–188. 1994. View Article : Google Scholar : PubMed/NCBI

4 

LeCouter J, Kowalski J, Foster J, Hass P, Zhang Z, Dillard-Telm L, Frantz G, Rangell L, DeGuzman L, Keller GA, et al: Identification of an angiogenic mitogen selective for endocrine gland endothelium. Nature. 412:877–884. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Soga T, Matsumoto S, Oda T, Saito T, Hijama H, Takasaki J, Kamohara M, Ohishi T, Matsushime H and Furuichi K: Molecular cloning and characterization of prokineticin receptors. Biochim Biophys Acta. 1579:173–179. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Lin DC, Bullock CM, Eheler FJ, Chen JL, Tian H and Zhou QY: Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor. J Biol Chem. 277:19276–19280. 2002. View Article : Google Scholar

7 

Masuda Y, Takatsu Y, Terao Y, Kumano S, Ishibashi Y, Suenaga M, Abe M, Fukusumi S, Watanabe T, Shintani Y, et al: Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors. Biochem Biophys Res Commun. 293:396–402. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Goi T, Yamaguchi A, Nakagawara G, Urano T, Shiku H and Furukawa K: Reduced expression of deleted colorectal carcinoma (DCC) protein in established colon cancers. Br J Cancer. 77:466–471. 1998. View Article : Google Scholar : PubMed/NCBI

9 

Yamaguchi A, Urano T, Goi T, Saito M, Takeuchi K, Hirose K, Nakagawara G, Shiku H and Furukawa K: Expression of a CD44 variant containing exons 8 to 10 is a useful independent factor for the prediction of prognosis in colorectal cancer patients. J Clin Oncol. 14:1122–1127. 1996.PubMed/NCBI

10 

Fujishima Y, Goi T, Kimura Y, Hirono Y, Katayama K and Yamaguchi A: MUC2 protein expression status is useful in assessing the effects of hyperthermic intraperitoneal chemotherapy for peritoneal dissemination of colon cancer. Int J Oncol. 40:960–964. 2012.

11 

Sawai K, Goi T, Hirono Y, Katayama K and Yamaguchi A: Survivin-3B gene decreases the invasion-inhibitory effect of colon cancer cells with 5-fluorouracil. Oncol Res. 18:541–547. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Goi T, Yamaguchi A, Takeuchi K, Nakagawa G, Yamashiro S, Furukawa K, Urano T and Shiku H: CD44 with variant exons 8-10 in colorectal tumors: expression analysis by a variant exon 9-specific monoclonal antibody. Int J Oncol. 8:657–662. 1996.PubMed/NCBI

13 

Ferrara N, Gerber HP and LeCouter J: The biology of VEGF and its receptors. Nat Med. 9:669–676. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Sakurai T and Kudo M: Signaling pathways governing tumor angiogenesis. Oncology. 81:24–29. 2011. View Article : Google Scholar

15 

Ferrara N and Davis-Smyth T: The biology of vascular endothelial growth factor. Endocr Rev. 18:4–25. 1997. View Article : Google Scholar

16 

Andrae J, Gallini R and Betsholtz C: Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 22:1276–1312. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, Berlin J, Baron A, Griffing S, Holmgren E, et al: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 350:2335–2342. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Giantonio BJ, Catalano PJ, Meropol NJ, O’Dwyer PJ, Mitchell EP, Alberts SR, Schwartz MA and Benson AB III: Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol. 25:1539–1544. 2007. View Article : Google Scholar

19 

Jonker DJ, O’Callaghan CJ, Karapetis CS, Zalcberg JR, Tu D, Au HJ, Berry SR, Krahn M, Price T, Simes RJ, et al: Cetuximab for the treatment of colorectal cancer. N Engl J Med. 357:2040–2048. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Cunningham D, Humblet Y, Siena S, Khayat D, Bleiberg H, Santoro A, Bets D, Mueser M, Harstrick A, Verslype C, et al: Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med. 351:337–345. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Van Cutsem E, Nowacki M, Lang I, Cascinu S, Shchepotin I, Maurel J, Rougier P, Cunningham D, Nippgen J and Kohne C: Randomized phase III study of irinotecan and 5-FU/LV with or without cetuximab in the first line treatment of patients with metastatic colorectal cancer. J Clin Oncol. 25:40002007.

22 

Van Cutsem E, Peeters M, Siena S, Humblet Y, Hendlisz A, Neyns B, Canon JL, Van Laethem JL, Maurel J, Richardson G, et al: Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol. 25:1658–1664. 2007.PubMed/NCBI

23 

Nagano H, Goi T, Koneri K, Hirono Y, Katayama K and Yamaguchi A: Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) expression in colorectal cancer. J Surg Oncol. 96:605–610. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Goi T, Fujioka M, Satoh Y, Tabata S, Koneri K, Nagano H, Hirono Y, Katayama K, Hirose K and Yamaguchi A: Angiogenesis and tumor proliferation/metastasis of human colorectal cancer cell line SW620 transfected with endocrine gland-derived-vascular endothelial growth factor, as a new angiogenic factor. Cancer Res. 64:1906–1910. 2004. View Article : Google Scholar

25 

Ngan ES, Sit FY, Lee K, Miao X, Yuan Z, Wang W, Nicholls JM, Wong KK, Garcia-Barcelo M, Lui VC and Tam PK: Implications of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression. Clin Cancer Res. 13:868–875. 2007. View Article : Google Scholar

26 

Pasquali D, Rossi V, Staibano S, De Rosa G, Chieffi P, Prezioso D, Mirone V, Mascolo M, Tramontano D, Bellastella A and Sinisi AA: The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: up-regulation of EG-VEGF/prokineticin 1 with malignancy. Endocrinology. 147:4245–4251. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Morales A, Vilchis F, Chávez B, Chan C, Robles-Díaz G and Díaz-Sánchez V: Expression and localization of endocrine gland-derived vascular endothelial growth factor (EG-VEGF) in human pancreas and pancreatic adenocarcinoma. J Steroid Biochem Mol Biol. 107:37–41. 2007. View Article : Google Scholar

28 

Jiang X, Abiatari I, Kong B, Erkan M, De Oliveira T, Giese NA, Michalski CW, Friess H and Kleeff J: Pancreatic islet and stellate cells are the main sources of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 in pancreatic cancer. Pancreatology. 9:165–172. 2009.

29 

Chakraborti S, Mandal M, Das S, Mandal A and Chakraborti T: Regulation of matrix metalloproteinases: an overview. Mol Cell Biochem. 253:269–285. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Rydlova M, Holubec L Jr, Ludvikova M Jr, Kalfert D, Franekova J, Povysil C and Ludvikova M: Biological activity and clinical implications of the matrix metalloproteinases. Anticancer Res. 28:1389–1397. 2008.PubMed/NCBI

31 

Zucker S and Vacirca J: Role of matrix metalloproteinases (MMPs) in colorectal cancer. Cancer Metastasis Rev. 23:101–117. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Tomita T and Iwata K: Matrix metaIloproteinases and tissue inhibitors of metalloproteinases in colonic adenomas-adeno-carcinomas. Dis Colon Rectum. 39:1255–1264. 1996. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tabata S, Goi T, Nakazawa T, Kimura Y, Katayama K and Yamaguchi A: Endocrine gland-derived vascular endothelial growth factor strengthens cell invasion ability via prokineticin receptor 2 in colon cancer cell lines. Oncol Rep 29: 459-463, 2013.
APA
Tabata, S., Goi, T., Nakazawa, T., Kimura, Y., Katayama, K., & Yamaguchi, A. (2013). Endocrine gland-derived vascular endothelial growth factor strengthens cell invasion ability via prokineticin receptor 2 in colon cancer cell lines. Oncology Reports, 29, 459-463. https://doi.org/10.3892/or.2012.2124
MLA
Tabata, S., Goi, T., Nakazawa, T., Kimura, Y., Katayama, K., Yamaguchi, A."Endocrine gland-derived vascular endothelial growth factor strengthens cell invasion ability via prokineticin receptor 2 in colon cancer cell lines". Oncology Reports 29.2 (2013): 459-463.
Chicago
Tabata, S., Goi, T., Nakazawa, T., Kimura, Y., Katayama, K., Yamaguchi, A."Endocrine gland-derived vascular endothelial growth factor strengthens cell invasion ability via prokineticin receptor 2 in colon cancer cell lines". Oncology Reports 29, no. 2 (2013): 459-463. https://doi.org/10.3892/or.2012.2124
Copy and paste a formatted citation
x
Spandidos Publications style
Tabata S, Goi T, Nakazawa T, Kimura Y, Katayama K and Yamaguchi A: Endocrine gland-derived vascular endothelial growth factor strengthens cell invasion ability via prokineticin receptor 2 in colon cancer cell lines. Oncol Rep 29: 459-463, 2013.
APA
Tabata, S., Goi, T., Nakazawa, T., Kimura, Y., Katayama, K., & Yamaguchi, A. (2013). Endocrine gland-derived vascular endothelial growth factor strengthens cell invasion ability via prokineticin receptor 2 in colon cancer cell lines. Oncology Reports, 29, 459-463. https://doi.org/10.3892/or.2012.2124
MLA
Tabata, S., Goi, T., Nakazawa, T., Kimura, Y., Katayama, K., Yamaguchi, A."Endocrine gland-derived vascular endothelial growth factor strengthens cell invasion ability via prokineticin receptor 2 in colon cancer cell lines". Oncology Reports 29.2 (2013): 459-463.
Chicago
Tabata, S., Goi, T., Nakazawa, T., Kimura, Y., Katayama, K., Yamaguchi, A."Endocrine gland-derived vascular endothelial growth factor strengthens cell invasion ability via prokineticin receptor 2 in colon cancer cell lines". Oncology Reports 29, no. 2 (2013): 459-463. https://doi.org/10.3892/or.2012.2124
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