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Article

Ginsenoside Rh2 mediates changes in the microRNA expression profile of human non-small cell lung cancer A549 cells

  • Authors:
    • In-Sook An
    • Sungkwan An
    • Ku Jung Kwon
    • Young Joo Kim
    • Seunghee Bae
  • View Affiliations / Copyright

    Affiliations: Korea Institute for Skin and Clinical Sciences, Seoul 143-701, Republic of Korea, Molecular-Targeted Drug Research Center, Seoul 143-701, Republic of Korea, Department of Bioengineering, Graduate School of Konkuk University, Seoul 143-701, Republic of Korea, Department of Skin Care and Beauty, Osan College, Osan-si, Gyeonggi-do 447-749, Republic of Korea
  • Pages: 523-528
    |
    Published online on: November 14, 2012
       https://doi.org/10.3892/or.2012.2136
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Abstract

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer insensitive to chemotherapy. Efforts are, therefore, directed toward understanding the molecular mechanisms of chemotherapy insensitivity and the development of new anticancer drugs. Ginsenoside Rh2, one of the components in ginseng saponin, has been shown to have anti-proliferative effect on human NSCLC cells and is being studied as a therapeutic drug for NSCLC. microRNAs (miRNAs) are small, non-coding RNA molecules that play a key role in cancer progression and prevention. However, the miRNA portrait of ginsenoside Rh2-treated NSCLC cells has not yet been studied. In this study, we identified a unique set of changes in the miRNA expression profile in response to Rh2 treatment in the human NSCLC cell line A549. Using miRNA microarray analysis, we identified 44 and 24 miRNAs displaying changes in expression greater than 2-fold in Rh2-treated A549 cells. In addition, using an miRNA target prediction program, we discovered that these miRNAs are predicted to have several target genes related to angiogenesis, apoptosis, chromatic modification, cell proliferation and differentiation. Thus, these results may assist in the better understanding of the anticancer mechanism of Rh2 in NSCLC.
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1 

Walker S: Updates in non-small cell lung cancer. Clin J Oncol Nurs. 12:587–596. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Gong HC, Wang S, Mayer G, et al: Signatures of drug sensitivity in nonsmall cell lung cancer. Int J Proteomics. August 7–2011.(Epub ahead of print). View Article : Google Scholar

3 

Ramalingam S and Belani CP: Recent advances in targeted therapy for non-small cell lung cancer. Expert Opin Ther Targets. 11:245–257. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Ambros V: microRNAs: tiny regulators with great potential. Cell. 107:823–826. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Ceppi P, Mudduluru G, Kumarswamy R, et al: Loss of miR-200c expression induces an aggressive, invasive and chemoresistant phenotype in non-small cell lung cancer. Mol Cancer Res. 8:1207–1216. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Markou A, Tsaroucha EG, Kaklamanis L, Fotinou M, Georgoulias V and Lianidou ES: Prognostic value of mature microRNA-21 and microRNA-205 overexpression in non-small cell lung cancer by quantitative real-time RT-PCR. Clin Chem. 54:1696–1704. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Zhang JG, Wang JJ, Zhao F, Liu Q, Jiang K and Yang GH: MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC). Clin Chim Acta. 411:846–852. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Zhu X, Li H, Long L, et al: miR-126 enhances the sensitivity of non-small cell lung cancer cells to anticancer agents by targeting vascular endothelial growth factor A. Acta Biochim Biophys Sin (Shanghai). 44:519–526. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Shibata S: Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds. J Korean Med Sci. (Suppl 16): S28–S37. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Bi WY, Fu BD, Shen HQ, et al: Sulfated derivative of 20(S)-ginsenoside Rh2 inhibits inflammatory cytokines through MAPKs and NF-kappa B pathways in LPS-induced RAW264.7 macrophages. Inflammation. 35:1659–1668. 2012. View Article : Google Scholar : PubMed/NCBI

11 

He L, Lee J, Jang JH, et al: Ginsenoside Rh2 inhibits osteoclastogenesis through down-regulation of NF-kappaB, NFATc1 and c-Fos. Bone. 50:1207–1213. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Luo JZ and Luo L: Ginseng on hyperglycemia: effects and mechanisms. Evid Based Complement Alternat Med. 6:423–427. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Wu N, Wu GC, Hu R, Li M and Feng H: Ginsenoside Rh2 inhibits glioma cell proliferation by targeting microRNA-128. Acta Pharmacol Sin. 32:345–353. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Li B, Zhao J, Wang CZ, et al: Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53. Cancer Lett. 301:185–192. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Zhang C, Yu H and Hou J: Effects of 20 (S)-ginsenoside Rh2 and 20 (R)-ginsenoside Rh2 on proliferation and apoptosis of human lung adenocarcinoma A549 cells. Zhongguo Zhong Yao Za Zhi. 36:1670–1674. 2011.(In Chinese).

16 

Cheng CC, Yang SM, Huang CY, Chen JC, Chang WM and Hsu SL: Molecular mechanisms of ginsenoside Rh2-mediated G1 growth arrest and apoptosis in human lung adenocarcinoma A549 cells. Cancer Chemother Pharmacol. 55:531–540. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Li Q, Li Y, Wang X, et al: Co-treatment with ginsenoside Rh2 and betulinic acid synergistically induces apoptosis in human cancer cells in association with enhanced capsase-8 activation, bax translocation, and cytochrome c release. Mol Carcinog. 50:760–769. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Jia WW, Bu X, Philips D, et al: Rh2, a compound extracted from ginseng, hypersensitizes multidrug-resistant tumor cells to chemotherapy. Can J Physiol Pharmacol. 82:431–437. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Hu S, Yu JY, Xiong LJ, Hu CP and Zhang YX: Research on the mechanism of ginsenoside Rh2 reversing the resistance of lung adenocarcinoma cells to cisplatin. Zhonghua Yi Xue Za Zhi. 90:264–268. 2010.(In Chinese).

20 

Hummel R, Watson DI, Smith C, et al: Mir-148a improves response to chemotherapy in sensitive and resistant oesophageal adenocarcinoma and squamous cell carcinoma cells. J Gastrointest Surg. 15:429–438. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Fujita Y, Kojima K, Ohhashi R, et al: MiR-148a attenuates paclitaxel resistance of hormone-refractory, drug-resistant prostate cancer PC3 cells by regulating MSK1 expression. J Biol Chem. 285:19076–19084. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Lehmann U, Hasemeier B, Christgen M, et al: Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer. J Pathol. 214:17–24. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Zheng B, Liang L, Wang C, et al: MicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer. Clin Cancer Res. 17:7574–7583. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Zhang H, Li Y, Huang Q, et al: MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal cancer. Cell Death Differ. 18:1702–1710. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Pillai RS, Bhattacharyya SN and Filipowicz W: Repression of protein synthesis by miRNAs: how many mechanisms? Trends Cell Biol. 17:118–126. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Yue PY, Mak NK, Cheng YK, et al: Pharmacogenomics and the Yin/Yang actions of ginseng: anti-tumor, angiomodulating and steroid-like activities of ginsenosides. Chin Med. 2:62007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
An I, An S, Kwon KJ, Kim YJ and Bae S: Ginsenoside Rh2 mediates changes in the microRNA expression profile of human non-small cell lung cancer A549 cells. Oncol Rep 29: 523-528, 2013.
APA
An, I., An, S., Kwon, K.J., Kim, Y.J., & Bae, S. (2013). Ginsenoside Rh2 mediates changes in the microRNA expression profile of human non-small cell lung cancer A549 cells. Oncology Reports, 29, 523-528. https://doi.org/10.3892/or.2012.2136
MLA
An, I., An, S., Kwon, K. J., Kim, Y. J., Bae, S."Ginsenoside Rh2 mediates changes in the microRNA expression profile of human non-small cell lung cancer A549 cells". Oncology Reports 29.2 (2013): 523-528.
Chicago
An, I., An, S., Kwon, K. J., Kim, Y. J., Bae, S."Ginsenoside Rh2 mediates changes in the microRNA expression profile of human non-small cell lung cancer A549 cells". Oncology Reports 29, no. 2 (2013): 523-528. https://doi.org/10.3892/or.2012.2136
Copy and paste a formatted citation
x
Spandidos Publications style
An I, An S, Kwon KJ, Kim YJ and Bae S: Ginsenoside Rh2 mediates changes in the microRNA expression profile of human non-small cell lung cancer A549 cells. Oncol Rep 29: 523-528, 2013.
APA
An, I., An, S., Kwon, K.J., Kim, Y.J., & Bae, S. (2013). Ginsenoside Rh2 mediates changes in the microRNA expression profile of human non-small cell lung cancer A549 cells. Oncology Reports, 29, 523-528. https://doi.org/10.3892/or.2012.2136
MLA
An, I., An, S., Kwon, K. J., Kim, Y. J., Bae, S."Ginsenoside Rh2 mediates changes in the microRNA expression profile of human non-small cell lung cancer A549 cells". Oncology Reports 29.2 (2013): 523-528.
Chicago
An, I., An, S., Kwon, K. J., Kim, Y. J., Bae, S."Ginsenoside Rh2 mediates changes in the microRNA expression profile of human non-small cell lung cancer A549 cells". Oncology Reports 29, no. 2 (2013): 523-528. https://doi.org/10.3892/or.2012.2136
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