Efficacy of a dose-intensified CHOP (Double-CHOP) regimen for peripheral T-cell lymphomas

  • Authors:
    • Noriyoshi Iriyama
    • Hiromichi Takahashi
    • Yoshihiro Hatta
    • Katsuhiro Miura
    • Yujin Kobayashi
    • Daisuke Kurita
    • Yukio Hirabayashi
    • Atsuko Hojo
    • Hitomi Kodaira
    • Mai Yagi
    • Satomi Kiso
    • Yoshihito Uchino
    • Masaru Nakagawa
    • Machiko Kusuda
    • Sumiko Kobayashi
    • Akira Horikoshi
    • Yoshimasa Kura
    • Tetsuo Yamazaki
    • Umihiko Sawada
    • Jin Takeuchi
  • View Affiliations

  • Published online on: November 15, 2012     https://doi.org/10.3892/or.2012.2143
  • Pages: 805-811
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Abstract

Peripheral T-cell lymphomas (PTCLs) are a rare and heterogeneous group of non-Hodgkin lymphomas, often resulting in poor prognoses. The CHOP chemotherapy regimen, which includes cyclophosphamide, doxorubicin, vincristine and prednisone, has been used previously to treat other types of lymphomas. Here, we examined the efficacy and safety of a dose-intensified CHOP regimen (Double-CHOP), which was followed by autologous stem-cell transplantation (ASCT) or high-dose methotrexate (HDMTX), in PTCL patients. Twenty-eight PTCL patients, who received 3 courses of Double-CHOP at our institution, were retrospectively studied from 1996 to 2012. Patients with anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+-ALCL) were excluded from this study. The median age of patients was 58 years (range: 17-69). They had low-intermediate (n=11), high-intermediate (n=10) or high (n=7) risk according to the International Prognostic Index (IPI). The overall complete remission (CR) rate following Double-CHOP treatment was 68%. Of the CR patients, 10 successfully tolerated a consolidated high-dose chemotherapy followed by ASCT and 7 received HDMTX. A single case of treatment-related mortality was recorded during the study. On a median 31-month follow-up, the estimated 3- or 5-year overall survival (OS) rates were 68 or 63%, respectively, while 3- or 5-year relapse-free survival (RFS) rates after CR were 60 or 43%, respectively. Although this study included elderly and excluded low-risk IPI and ALK+-ALCL patients, OS results were superiorly favourable, indicating the efficacy of this Double-CHOP regimen. However, an effective treatment strategy for refractory or relapsing patients needs to be validated and established.
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February 2013
Volume 29 Issue 2

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Spandidos Publications style
Iriyama N, Takahashi H, Hatta Y, Miura K, Kobayashi Y, Kurita D, Hirabayashi Y, Hojo A, Kodaira H, Yagi M, Yagi M, et al: Efficacy of a dose-intensified CHOP (Double-CHOP) regimen for peripheral T-cell lymphomas. Oncol Rep 29: 805-811, 2013
APA
Iriyama, N., Takahashi, H., Hatta, Y., Miura, K., Kobayashi, Y., Kurita, D. ... Takeuchi, J. (2013). Efficacy of a dose-intensified CHOP (Double-CHOP) regimen for peripheral T-cell lymphomas. Oncology Reports, 29, 805-811. https://doi.org/10.3892/or.2012.2143
MLA
Iriyama, N., Takahashi, H., Hatta, Y., Miura, K., Kobayashi, Y., Kurita, D., Hirabayashi, Y., Hojo, A., Kodaira, H., Yagi, M., Kiso, S., Uchino, Y., Nakagawa, M., Kusuda, M., Kobayashi, S., Horikoshi, A., Kura, Y., Yamazaki, T., Sawada, U., Takeuchi, J."Efficacy of a dose-intensified CHOP (Double-CHOP) regimen for peripheral T-cell lymphomas". Oncology Reports 29.2 (2013): 805-811.
Chicago
Iriyama, N., Takahashi, H., Hatta, Y., Miura, K., Kobayashi, Y., Kurita, D., Hirabayashi, Y., Hojo, A., Kodaira, H., Yagi, M., Kiso, S., Uchino, Y., Nakagawa, M., Kusuda, M., Kobayashi, S., Horikoshi, A., Kura, Y., Yamazaki, T., Sawada, U., Takeuchi, J."Efficacy of a dose-intensified CHOP (Double-CHOP) regimen for peripheral T-cell lymphomas". Oncology Reports 29, no. 2 (2013): 805-811. https://doi.org/10.3892/or.2012.2143