Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
February 2013 Volume 29 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February 2013 Volume 29 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

SLC gene-modified dendritic cells mediate T cell-dependent anti-gastric cancer immune responses in vitro

  • Authors:
    • Gang Xue
    • Ying Cheng
    • Feng Ran
    • Xianhui Li
    • Tao Huang
    • Yong Yang
    • Yanbiao Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Breast and Thyroid Surgery, Chengdu Army General Hospital, Chengdu 610083, P.R. China, Department of Endocrinology, Chengdu Army General Hospital, Chengdu 610083, P.R. China
  • Pages: 595-604
    |
    Published online on: November 28, 2012
       https://doi.org/10.3892/or.2012.2154
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Dendritic cells (DCs) are potent professional antigen-presenting cells (APCs) with the ability to prime naïve T cells, and play an important role in the initiation and regulation of immune responses. In this study, we constructed a recombinant adenovirus carrying the SLC gene (Ad-SLC), and detected the biological effects of Ad-SLC-modified DCs as an adjuvant for the initiation of gastric cancer immune responses. Human DCs were transfected with Ad-SLC and the recombinant adenovirus carrying the β-galactosidase gene, Ad-LacZ, respectively. Modified DCs were pulsed with the cell lysate antigen of SGC-7901 cells (a type of gastric cancer cell line) and co-cultured with autologous T cells. The T cells were harvested and incubated with SGC-7901 cells and the cytotoxic function of the T cells was detected. Based on the data, the expression of mature DC phenotypes CD83 and CCR7 was upregulated after transfection with Ad-SLC and the chemotaxis function of DCs was augmented after transfection with Ad-SLC. Moreover, the expression of RANTES in DCs was upregul­ated by Ad-SLC transfection, while expression levels of IL-12p70 and IL-10 were not significantly altered. When co-cultured with autologous T cells, DCs modified with the SLC gene and pulsed with SGC-7901 cell lysates significantly promoted the proliferation of autologous T cells and induced Th1 differenti­ation, and displayed a strong cytotoxicity to SGC-7901 cells. In conclusion, Ad-SLC promoted DC maturation, enhancing the ability of DCs for T-cell chemotaxis and T-cell stimulation, and induced specific anti-gastric cancer cellular immunity. Recombinant Ad-SLC-modified DCs may be used as an adjuvant to induce an effective anti-gastric cancer immune response.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Huang AY, Golumbek P, Ahmadzadeh M, Jaffee E, Pardoll D and Levitsky H: Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. Science. 264:961–965. 1994. View Article : Google Scholar : PubMed/NCBI

2 

Restifo NP, Esquivel F, Kawakami Y, Yewdell JW, Mulé JJ, Rosenberg SA and Bennink JR: Identification of human cancers deficient in antigen processing. J Exp Med. 177:265–272. 1993. View Article : Google Scholar : PubMed/NCBI

3 

Li L, Liu D, Hutt-Fletcher L, Morgan A, Masucci MG and Levitsky V: Epstein-Barr virus inhibits the development of dendritic cells by promoting apoptosis of their monocyte precursors in the presence of granulocyte macrophage-colony-stimulating factor and interleukin-4. Blood. 99:3725–3734. 2000. View Article : Google Scholar

4 

Lambrecht BN, Salomon B, Klatzmann D and Pauwels RA: Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice. J Immunol. 160:4090–4097. 1998.PubMed/NCBI

5 

Banchereau J and Steinman RM: Dendritic cells and the control of immunity. Nature. 392:245–252. 1998. View Article : Google Scholar

6 

Steinman RM, Pack M and Inaba K: Dendritic cells in the T-cell areas of lymphoid organs. Immunol Rev. 156:25–37. 1997. View Article : Google Scholar : PubMed/NCBI

7 

Tan MC, Mommaas AM, Drijfhout JW, Jordens R, Onderwater JJ, Verwoerd D, Mulder AA, van der Heiden AN, Scheidegger D, Oomen LC, Ottenhoff TH, Tulp A, Neefjes JJ and Koning F: Mannose receptor mediated uptake of antigens strongly enhances HLA class II-restricted antigen presentation by cultured dendritic cells. Eur J Immunol. 27:2426–2435. 1997. View Article : Google Scholar

8 

Nair SK, Hull S, Coleman D, Gilboa E, Lyerly HK and Morse MA: Induction of carcinoembryonic antigen (CEA)-specific cytotoxic T-lymphocyte responses in vitro using autologous dendritic cells loaded with CEA peptide or CEA RNA in patients with metastatic malignancies expressing CEA. Int J Cancer. 82:121–124. 1999. View Article : Google Scholar

9 

Timmerman JM and Levy R: Dendritic cell vaccines for cancer immunotherapy. Annu Rev Med. 50:507–529. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Lodge PA, Jones LA, Bader RA, Murphy GP and Salgaller ML: Dendritic cell-based immunotherapy of prostate cancer: immune monitoring of a phase II clinical trial. Cancer Res. 60:829–833. 2000.PubMed/NCBI

11 

Nestle FO, Alijagic S, Gilliet M, Sun Y, Grabbe S, Dummer R, Burg G and Schadendorf D: Vaccination of melanoma patients with peptide or tumor lysate-pulsed dendritic cells. Nat Med. 4:328–332. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Bell D, Young JW and Banchereau J: Dendritic cells. Adv Immunol. 72:255–324. 1999. View Article : Google Scholar

13 

Henderson RA, Nimgaonkar MT, Watkins SC, Robbins PD, Ball ED and Finn OJ: Human dendritic cells genetically engineered to express high levels of the human epithelial tumor antigen mucin (MUC-1). Cancer Res. 56:3763–3770. 1996.PubMed/NCBI

14 

Ribas A, Bui LA, Butterfield LH, Vollmer CM, Jilani SM, Dissette VB, Glaspy JA, McBride WH and Economou JS: Antitumor protection using murine dendritic cells pulsed with acid-eluted peptides from in vivo grown tumors of different immunogenicities. Anticancer Res. 19:1165–1170. 1999.

15 

Miller PW, Sharma S, Stolina M, Butterfield LH, Luo J, Lin Y, Dohadwala M, Batra RK, Wu L, Economou JS and Dubinett SM: Intratumoral administration of adenoviral interleukin 7 gene-modified dendritic cells augments specific antitumor immunity and achieves tumor eradication. Hum Gene Ther. 11:53–65. 2000. View Article : Google Scholar

16 

Cao X, Zhang W, He L, Xie Z, Ma S, Tao Q, Yu Y, Hamada H and Wang J: Lymphotactin gene-modified bone marrow dendritic cells act as more potent adjuvants for peptide delivery to induce specific antitumor immunity. J Immunol. 161:6238–6244. 1998.PubMed/NCBI

17 

Celluzzi CM and Falo LD Jr: Physical interaction between dendritic cells and tumor cells results in an immunogen that induces protective and therapeutic tumor rejection. J Immunol. 160:3081–3085. 1998.

18 

Ribas A, Butterfield LH, McBride WH, Jilani SM, Bui LA, Vollmer CM, Lau R, Dissette VB, Hu B, Chen AY, Glaspy JA and Economou JS: Genetic immunization for the melanoma antigen MART-1/Melan-A using recombinant adenovirus-transfected murine dendritic cells. Cancer Res. 57:2865–2869. 1997.

19 

Lyakh LA, Koski GK, Young HA, Spence SE, Cohen PA and Rice NR: Adenovirus type 5 vector induces dendritic cell differentiation in human CD14+ monocytes cultured under serum-free conditions. Blood. 99:600–608. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Lundqvist A, Choudhury A, Nagata T, Andersson T, Quinn G, Fong T, Maitland N, Pettersson S, Paulie S and Pisa P: Recombinant adenovirus vector activates and protects human monocyte derived dendritic cells from apoptosis. Hum Gene Ther. 13:1541–1549. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Miller G, Lahrs S, Pillarisetty VG, Shah AB and DeMatteo RP: Adenovirus infection enhances dendritic cell immunostimulatory properties and induces natural killer and T-cell-mediated tumor protection. Cancer Res. 62:5260–5266. 2002.

22 

Kirk CJ, Hartigan-O’Connor D and Mulé JJ: The dynamics of the T cell antitumor response: chemokine-secreting dendritic cells can prime tumor-reactive T cells extranodally. Cancer Res. 61:8794–8802. 2001.PubMed/NCBI

23 

Kirk CJ, Hartigan-O’Connor D, Nickoloff BJ, Chamberlain JS, Giedlin M, Aukerman L and Mule JJ: T cell-dependent antitumor immunity mediated by secondary lymphoid tissue chemokine: augmentation of dendritic cell-based immunotherapy. Cancer Res. 61:2062–2070. 2001.PubMed/NCBI

24 

Baggiolini M, Dewald B and Moser B: Human chemokines: an update. Annu Rev Immunol. 15:675–705. 1997. View Article : Google Scholar : PubMed/NCBI

25 

Gunn MD, Tangemann K, Tam C, Cyster JG, Rosen SD and Williams LT: A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naïve T lymphocytes. Proc Natl Acad Sci USA. 95:258–263. 1998.PubMed/NCBI

26 

Cyster JG: Chemokines and the homing of dendritic cells to the T cell areas of lymphoid organs. J Exp Med. 189:447–450. 1999. View Article : Google Scholar : PubMed/NCBI

27 

Chan VW, Kothakota S, Rohan MC, Panganiban-Lustan L, Gardner JP, Wachowicz MS, Winter JA and Williams LT: Secondary lymphoid-tissue chemokine (SLC) is chemotactic for mature dendritic cells. Blood. 93:3610–3616. 1999.PubMed/NCBI

28 

Hromas R, Kim CH, Klemsz M, Krathwohl M, Fife K, Cooper S, Schnizlein-Bick C and Broxmeyer HE: Isolation and characterization of Exodus-2, a novel CC chemokine with a unique 37 amino acid carboxyl-terminal extension. J Immunol. 159:2554–2558. 1997.PubMed/NCBI

29 

Willimann K, Legler DF, Loetscher M, Roos RS, Delgado MB, Clark-Lewis I, Baggiolini M and Moser B: The chemokine SLC is expressed in T cell areas of lymph nodes and mucosal lymphoid tissues and attracts activated T cells via CCR7. Eur J Immunol. 28:2025–2034. 1998. View Article : Google Scholar : PubMed/NCBI

30 

Nagira M, Imai T, Hieshima K, Kusuda J, Ridanpää M, Takagi S, Nishimura M, Kakizaki M, Nomiyama H and Yoshie O: Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13. J Biol Chem. 272:19518–19524. 1997. View Article : Google Scholar : PubMed/NCBI

31 

Gunn MD, Kyuwa S, Tam C, Kakiuchi T, Matsuzawa A, Williams LT and Nakano H: Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J Exp Med. 189:451–460. 1999. View Article : Google Scholar : PubMed/NCBI

32 

Soto H, Wang W, Strieter RM, Copeland NG, Gilbert DJ, Jenkins NA, Hedrick J and Zlotnik A: The CC chemokine SLC binds the CXC chemokine receptor CXCR3. Proc Natl Acad Sci USA. 95:8205–8210. 1998. View Article : Google Scholar : PubMed/NCBI

33 

Sharma S, Stolina M, Luo J, Strieter RM, Burdick M, Zhu LX, Batra RK and Dubinett SM: Secondary lymphoid tissue chemokine mediates T cell-dependent antitumor responses in vivo. J Immunol. 164:4558–4563. 2000. View Article : Google Scholar : PubMed/NCBI

34 

Sharma S, Stolina M, Zhu L, Lin Y, Batra R, Huang M, Strieter R and Dubinett SM: Secondary lymphoid organ chemokine reduces pulmonary tumor burden in spontaneous murine bronchoalveolar cell carcinoma. Cancer Res. 61:6406–6412. 2001.PubMed/NCBI

35 

Nishimura N, Nishioka Y, Shinohara T, Ogawa H, Yamamoto S, Tani K and Sone S: Novel centrifugal method for simple and highly efficient adenovirus-mediated green fluorescence protein gene transfection into human monocyte-derived dendritic cells. J Immunol Methods. 253:113–124. 2001. View Article : Google Scholar

36 

Nishimura N, Nishioka Y, Shinohara T and Sone S: Enhanced efficiency by centrifugal manipulation of adenovirus-mediated interleukin 12 gene transduction into human monocyte-derived dendritic cells. Hum Gene Ther. 12:333–346. 2001. View Article : Google Scholar

37 

Arthur JF, Butterfield LH, Roth MD, Bui LA, Kiertscher SM, Lau R, Dubinett S, Glaspy J, McBride WH and Economou JS: A comparison of gene transfer methods in human dendritic cells. Cancer Gene Ther. 4:17–25. 1997.PubMed/NCBI

38 

Zhong L, Granelli-Piperno A, Choi Y and Steinman RM: Recombinant adenovirus is an efficient and non-perturbing genetic vector for human dendritic cells. Eur J Immunol. 29:964–972. 1999. View Article : Google Scholar : PubMed/NCBI

39 

Fasbender A, Zabner J, Chillón M, Moninger TO, Puga AP, Davidson BL and Welsh MJ: Complexes of adenovirus with polycationic polymers and cationic lipids increase the efficiency of gene transfer in vitro and in vivo. J Biol Chem. 272:6479–6489. 1997. View Article : Google Scholar : PubMed/NCBI

40 

Dietz AB and Vuk-Pavlović S: High efficiency adenovirus-mediated gene transfer to human dendritic cells. Blood. 91:392–398. 1998.PubMed/NCBI

41 

Christopherson KW II, Campbell JJ and Hromas RA: Transgenic overexpression of the CC chemokine CCL21 disrupts T-cell migration. Blood. 98:3562–3568. 2001. View Article : Google Scholar : PubMed/NCBI

42 

Förster R, Schubel A, Breitfeld D, Kremmer E, Renner-Müller I, Wolf E and Lipp M: CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell. 99:23–33. 1999.PubMed/NCBI

43 

Bromley SK, Thomas SY and Luster AD: Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics. Nat Immunol. 6:895–901. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Bacon KB, Premack BA, Gardner P and Schall TJ: Activation of dual T cell signaling pathways by the chemokine RANTES. Science. 269:1727–1730. 1995. View Article : Google Scholar : PubMed/NCBI

45 

Dairaghi DJ, Soo KS, Oldham ER, Premack BA, Kitamura T, Bacon KB and Schall TJ: RANTES-induced T cell activation correlates with CD3 expression. J Immunol. 160:426–433. 1998.PubMed/NCBI

46 

Appay V, Dunbar PR, Cerundolo V, McMichael A, Czaplewski L and Rowland-Jones S: RANTES activates antigen-specific cytotoxic T lymphocytes in a mitogen-like manner through cell surface aggregation. Int Immunol. 12:1173–1182. 2000. View Article : Google Scholar : PubMed/NCBI

47 

Guo Z, Zhang M, Tang H and Cao X: Fas signal links innate and adaptive immunity by promoting dendritic-cell secretion of CC and CXC chemokines. Blood. 106:2033–2041. 2005. View Article : Google Scholar : PubMed/NCBI

48 

Flanagan K, Moroziewicz D, Kwak H, Hörig H and Kaufman HL: The lymphoid chemokine CCL21 costimulates naive T cell expansion and Th1 polarization of non-regulatory CD4+ T cells. Cell Immunol. 231:75–84. 2004. View Article : Google Scholar : PubMed/NCBI

49 

Marsland BJ, Bättig P, Bauer M, Ruedl C, Lässing U, Beerli RR, Dietmeier K, Ivanova L, Pfister T, Vogt L, Nakano H, Nembrini C, Saudan P, Kopf M and Bachmann MF: CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells. Immunity. 22:493–505. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xue G, Cheng Y, Ran F, Li X, Huang T, Yang Y and Zhang Y: SLC gene-modified dendritic cells mediate T cell-dependent anti-gastric cancer immune responses in vitro. Oncol Rep 29: 595-604, 2013.
APA
Xue, G., Cheng, Y., Ran, F., Li, X., Huang, T., Yang, Y., & Zhang, Y. (2013). SLC gene-modified dendritic cells mediate T cell-dependent anti-gastric cancer immune responses in vitro. Oncology Reports, 29, 595-604. https://doi.org/10.3892/or.2012.2154
MLA
Xue, G., Cheng, Y., Ran, F., Li, X., Huang, T., Yang, Y., Zhang, Y."SLC gene-modified dendritic cells mediate T cell-dependent anti-gastric cancer immune responses in vitro". Oncology Reports 29.2 (2013): 595-604.
Chicago
Xue, G., Cheng, Y., Ran, F., Li, X., Huang, T., Yang, Y., Zhang, Y."SLC gene-modified dendritic cells mediate T cell-dependent anti-gastric cancer immune responses in vitro". Oncology Reports 29, no. 2 (2013): 595-604. https://doi.org/10.3892/or.2012.2154
Copy and paste a formatted citation
x
Spandidos Publications style
Xue G, Cheng Y, Ran F, Li X, Huang T, Yang Y and Zhang Y: SLC gene-modified dendritic cells mediate T cell-dependent anti-gastric cancer immune responses in vitro. Oncol Rep 29: 595-604, 2013.
APA
Xue, G., Cheng, Y., Ran, F., Li, X., Huang, T., Yang, Y., & Zhang, Y. (2013). SLC gene-modified dendritic cells mediate T cell-dependent anti-gastric cancer immune responses in vitro. Oncology Reports, 29, 595-604. https://doi.org/10.3892/or.2012.2154
MLA
Xue, G., Cheng, Y., Ran, F., Li, X., Huang, T., Yang, Y., Zhang, Y."SLC gene-modified dendritic cells mediate T cell-dependent anti-gastric cancer immune responses in vitro". Oncology Reports 29.2 (2013): 595-604.
Chicago
Xue, G., Cheng, Y., Ran, F., Li, X., Huang, T., Yang, Y., Zhang, Y."SLC gene-modified dendritic cells mediate T cell-dependent anti-gastric cancer immune responses in vitro". Oncology Reports 29, no. 2 (2013): 595-604. https://doi.org/10.3892/or.2012.2154
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team