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Article Open Access

Increased expression of placental growth factor in high-grade endometrial carcinoma

  • Authors:
    • Lieve Coenegrachts
    • Stefanie Schrauwen
    • Rita Van Bree
    • Evelyn  Despierre
    • Catherine  Luyten
    • Bart Jonckx
    • Jean  Marie Stassen
    • Ignace Vergote
    • Frédéric Amant
  • View Affiliations / Copyright

    Affiliations: Division of Gynecologic Oncology, Department of Oncology, KU Leuven, B-3000 Leuven, Belgium, ThromboGenics NV, B-3001 Heverlee, Belgium
    Copyright: © Coenegrachts et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 413-418
    |
    Published online on: December 10, 2012
       https://doi.org/10.3892/or.2012.2178
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Abstract

Placental growth factor (PlGF), a homolog of vascular endothelial growth factor (VEGF), exerts pleiotropic functions in cancer by affecting tumor cells as well as endothelial and inflammatory cells. Moreover, PlGF expression correlates with tumor stage, recurrence, metastasis and patient outcome in different types of cancer. Recently, administration of anti-PlGF therapy reduced tumor growth and metastasis in preclinical tumor models. In the present study, we evaluated the diagnostic and prognostic value of systemic and local expression of PlGF in primary endometrial carcinomas. PlGF levels in tumor lysates (n=128) and serum (n=88) of patients with primary endometrial cancer were determined using ELISA. PlGF mRNA expression in endometrial carcinoma tissues was quantified by quantitative qRT-PCR. Results were compared to endometrial cancer stage and grade. Systemic PlGF levels were not altered in patients with endometrial cancer (FIGO stage I-II-III) as compared to healthy controls. Only in FIGO stage IV patients, serum PlGF levels were slightly increased. Local PlGF mRNA and protein expression in endometrial tumors progressively increased with tumor grade. In endometrioid carcinomas, PlGF mRNA expression was significantly increased in endometrioid grade 3 tumors as compared to normal endometrial tissue. PlGF protein expression was significantly increased in endometrioid grade 2 and 3 carcinomas and in serous carcinomas as compared to normal endometrial tissue. Our study showed that systemic/serum PlGF levels cannot be used as a diagnostic or prognostic marker in endometrial cancer. However, the increased local expression of PlGF, primarily in high-grade carcinomas, underscores the possibility for preclinical assessment of anti-PlGF therapy in endometrial cancer.
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1 

Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin. 60:277–300. 2010. View Article : Google Scholar

2 

Zannoni GF, Scambia G and Gallo D: The dualistic model of endometrial cancer: the challenge of classifying grade 3 endometrioid carcinoma. Gynecol Oncol. 127:262–263. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Amant F, Moerman P, Neven P, Timmerman D, Van LE and Vergote I: Endometrial cancer. Lancet. 366:491–505. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Kamat AA, Merritt WM, Coffey D, Lin YG, Patel PR, Broaddus R, Nugent E, Han LY, Landen CN Jr, Spannuth WA, Lu C, Coleman RL, Gershenson DM and Sood AK: Clinical and biological significance of vascular endothelial growth factor in endometrial cancer. Clin Cancer Res. 13:7487–7495. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Rasila KK, Burger RA, Smith H, Lee FC and Verschraegen C: Angiogenesis in gynecological oncology-mechanism of tumor progression and therapeutic targets. Int J Gynecol Cancer. 15:710–726. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Seki N, Kodama J, Hongo A, Miyagi Y, Yoshinouchi M and Kudo T: Vascular endothelial growth factor and platelet-derived endothelial cell growth factor expression are implicated in the angiogenesis of endometrial cancer. Eur J Cancer. 36:68–73. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Stefansson IM, Salvesen HB and Akslen LA: Vascular proliferation is important for clinical progress of endometrial cancer. Cancer Res. 66:3303–3309. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Kerbel RS: Tumor angiogenesis. N Engl J Med. 358:2039–2049. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Fischer C, Mazzone M, Jonckx B and Carmeliet P: FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy? Nat Rev Cancer. 8:942–956. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Carmeliet P, Moons L, Luttun A, Vincenti V, Compernolle V, De MM, Wu Y, Bono F, Devy L, Beck H, Scholz D, Acker T, DiPalma T, Dewerchin M, Noel A, Stalmans I, Barra A, Blacher S, Vandendriessche T, Ponten A, Eriksson U, Plate KH, Foidart JM, Schaper W, Charnock-Jones DS, Hicklin DJ, Herbert JM, Collen D and Persico MG: Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat Med. 7:575–583. 2001. View Article : Google Scholar

11 

Fischer C, Jonckx B, Mazzone M, Zacchigna S, Loges S, Pattarini L, Chorianopoulos E, Liesenborghs L, Koch M, De MM, Autiero M, Wyns S, Plaisance S, Moons L, van RN, Giacca M, Stassen JM, Dewerchin M, Collen D and Carmeliet P: Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. Cell. 131:463–475. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Coenegrachts L, Maes C, Torrekens S, Van LR, Mazzone M, Guise TA, Bouillon R, Stassen JM, Carmeliet P and Carmeliet G: Anti-placental growth factor reduces bone metastasis by blocking tumor cell engraftment and osteoclast differentiation. Cancer Res. 70:6537–6547. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Van de Veire S, Stalmans I, Heindryckx F, Oura H, Tijeras-Raballand A, Schmidt T, Loges S, Albrecht I, Jonckx B, Vinckier S, Van SC, Tugues S, Rolny C, De MM, Dettori D, Hainaud P, Coenegrachts L, Contreres JO, Van BT, Cuervo H, Xiao WH, Le HC, Buysschaert I, Kharabi MB, Geerts A, Schomber T, Bonnin P, Lambert V, Haustraete J, Zacchigna S, Rakic JM, Jimenez W, Noel A, Giacca M, Colle I, Foidart JM, Tobelem G, Morales-Ruiz M, Vilar J, Maxwell P, Vinores SA, Carmeliet G, Dewerchin M, Claesson-Welsh L, Dupuy E, Van VH, Christofori G, Mazzone M, Detmar M, Collen D and Carmeliet P: Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease. Cell. 141:178–190. 2010.PubMed/NCBI

14 

Maae E, Olsen DA, Steffensen KD, Jakobsen EH, Brandslund I, Sorensen FB and Jakobsen A: Prognostic impact of placenta growth factor and vascular endothelial growth factor A in patients with breast cancer. Breast Cancer Res Treat. 133:257–265. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Parr C, Watkins G, Boulton M, Cai J and Jiang WG: Placenta growth factor is over-expressed and has prognostic value in human breast cancer. Eur J Cancer. 41:2819–2827. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Wei SC, Tsao PN, Yu SC, Shun CT, Tsai-Wu JJ, Wu CH, Su YN, Hsieh FJ and Wong JM: Placenta growth factor expression is correlated with survival of patients with colorectal cancer. Gut. 54:666–672. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Sivridis E, Giatromanolaki A, Anastasiadis P, Georgiou L, Gatter KC, Harris AL, Bicknell R and Koukourakis MI: Angiogenic co-operation of VEGF and stromal cell TP in endometrial carcinomas. J Pathol. 196:416–422. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Pecorelli S: Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet. 105:103–104. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Luttun A, Tjwa M, Moons L, Wu Y, Angelillo-Scherrer A, Liao F, Nagy JA, Hooper A, Priller J, De KB, Compernolle V, Daci E, Bohlen P, Dewerchin M, Herbert JM, Fava R, Matthys P, Carmeliet G, Collen D, Dvorak HF, Hicklin DJ and Carmeliet P: Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med. 8:831–840. 2002.PubMed/NCBI

20 

Koukourakis MI, Limberis V, Tentes I, Kontomanolis E, Kortsaris A, Sivridis E and Giatromanolaki A: Serum VEGF levels and tissue activation of VEGFR2/KDR receptors in patients with breast and gynecologic cancer. Cytokine. 53:370–375. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Chang YT, Chang MC, Wei SC, Tien YW, Hsu C, Liang PC, Tsao PN, Jan IS and Wong JM: Serum vascular endothelial growth factor/soluble vascular endothelial growth factor receptor 1 ratio is an independent prognostic marker in pancreatic cancer. Pancreas. 37:145–150. 2008. View Article : Google Scholar

22 

Pompeo E, Albonici L, Doldo E, Orlandi A, Manzari V, Modesti A and Mineo TC: Placenta growth factor expression has prognostic value in malignant pleural mesothelioma. Ann Thorac Surg. 88:426–431. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Wei SC, Liang JT, Tsao PN, Hsieh FJ, Yu SC and Wong JM: Preoperative serum placenta growth factor level is a prognostic biomarker in colorectal cancer. Dis Colon Rectum. 52:1630–1636. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Zhang L, Chen J, Ke Y, Mansel RE and Jiang WG: Expression of placenta growth factor (PlGF) in non-small cell lung cancer (NSCLC) and the clinical and prognostic significance. World J Surg Oncol. 3:682005. View Article : Google Scholar : PubMed/NCBI

25 

Chen CN, Hsieh FJ, Cheng YM, Cheng WF, Su YN, Chang KJ and Lee PH: The significance of placenta growth factor in angiogenesis and clinical outcome of human gastric cancer. Cancer Lett. 213:73–82. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Voss MA, Ganesan R, Ludeman L, McCarthy K, Gornall R, Schaller G, Wei W and Sundar S: Should grade 3 endometrioid endometrial carcinoma be considered a type 2 cancer-A clinical and pathological evaluation. Gynecol Oncol. 124:15–20. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Martinsson-Niskanen T, Riisbro R, Larsson L, Winstedt L, Stenberg Y, Pakola S, Stassen JM and Glazer S: Monoclonal antibody TB-403: a first-in-human, Phase I, double-blind, dose escalation study directed against placental growth factor in healthy male subjects. Clin Ther. 33:1142–1149. 2011. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Coenegrachts L, Schrauwen S, Van Bree R, Despierre E, Luyten C, Jonckx B, Stassen JM, Vergote I and Amant F: Increased expression of placental growth factor in high-grade endometrial carcinoma. Oncol Rep 29: 413-418, 2013.
APA
Coenegrachts, L., Schrauwen, S., Van Bree, R., Despierre, E., Luyten, C., Jonckx, B. ... Amant, F. (2013). Increased expression of placental growth factor in high-grade endometrial carcinoma. Oncology Reports, 29, 413-418. https://doi.org/10.3892/or.2012.2178
MLA
Coenegrachts, L., Schrauwen, S., Van Bree, R., Despierre, E., Luyten, C., Jonckx, B., Stassen, J. M., Vergote, I., Amant, F."Increased expression of placental growth factor in high-grade endometrial carcinoma". Oncology Reports 29.2 (2013): 413-418.
Chicago
Coenegrachts, L., Schrauwen, S., Van Bree, R., Despierre, E., Luyten, C., Jonckx, B., Stassen, J. M., Vergote, I., Amant, F."Increased expression of placental growth factor in high-grade endometrial carcinoma". Oncology Reports 29, no. 2 (2013): 413-418. https://doi.org/10.3892/or.2012.2178
Copy and paste a formatted citation
x
Spandidos Publications style
Coenegrachts L, Schrauwen S, Van Bree R, Despierre E, Luyten C, Jonckx B, Stassen JM, Vergote I and Amant F: Increased expression of placental growth factor in high-grade endometrial carcinoma. Oncol Rep 29: 413-418, 2013.
APA
Coenegrachts, L., Schrauwen, S., Van Bree, R., Despierre, E., Luyten, C., Jonckx, B. ... Amant, F. (2013). Increased expression of placental growth factor in high-grade endometrial carcinoma. Oncology Reports, 29, 413-418. https://doi.org/10.3892/or.2012.2178
MLA
Coenegrachts, L., Schrauwen, S., Van Bree, R., Despierre, E., Luyten, C., Jonckx, B., Stassen, J. M., Vergote, I., Amant, F."Increased expression of placental growth factor in high-grade endometrial carcinoma". Oncology Reports 29.2 (2013): 413-418.
Chicago
Coenegrachts, L., Schrauwen, S., Van Bree, R., Despierre, E., Luyten, C., Jonckx, B., Stassen, J. M., Vergote, I., Amant, F."Increased expression of placental growth factor in high-grade endometrial carcinoma". Oncology Reports 29, no. 2 (2013): 413-418. https://doi.org/10.3892/or.2012.2178
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