Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients

  • Authors:
    • Olga Martinho
    • Kleber Simões
    • Adhemar Longatto-Filho
    • Carlos Eduardo Jacob
    • Bruno Zilberstein
    • Cláudio Bresciani
    • Joaquim Gama-Rodrigues
    • Ivan Cecconello
    • Venâncio Alves
    • Rui Manuel Reis
  • View Affiliations

  • Published online on: December 10, 2012     https://doi.org/10.3892/or.2012.2179
  • Pages: 690-696
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Abstract

Gastric cancer is a leading cause of cancer-related mortality, and the presence of lymph node metastasis an important prognostic factor. Downregulation of RKIP has been associated with tumor progression and metastasis in several types of neoplasms, being currently categorized as a metastasis suppressor gene. Our aim was to determine the expression levels of RKIP in gastric tissues and to evaluate its impact in the clinical outcome of gastric carcinoma patients. RKIP expression levels were studied by immunohistochemistry in a series of gastric tissues. Overall, we analysed 222 non-neoplastic gastric tissues, 152 primary tumors and 42 lymph node metastasis samples. We observed that RKIP was highly expressed in ~83% of non-neoplastic tissues (including normal tissue and metaplasia), was lost in ~56% of primary tumors and in ~90% of lymph node metastasis samples. Loss of RKIP expression was significantly associated with several markers of poor clinical outcome, including the presence of lymph node metastasis. Furthermore, the absence of RKIP protein constitutes an independent prognostic marker for these patients. In conclusion, RKIP expression is significantly lost during gastric carcinoma progression being almost absent in lymph node metastasis samples. Of note, we showed that the absence of RKIP expression is associated with poor outcome features of gastric cancer patients, this being also an independent prognostic marker.
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February 2013
Volume 29 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Martinho O, Simões K, Longatto-Filho A, Jacob CE, Zilberstein B, Bresciani C, Gama-Rodrigues J, Cecconello I, Alves V, Reis RM, Reis RM, et al: Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients. Oncol Rep 29: 690-696, 2013
APA
Martinho, O., Simões, K., Longatto-Filho, A., Jacob, C.E., Zilberstein, B., Bresciani, C. ... Reis, R.M. (2013). Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients. Oncology Reports, 29, 690-696. https://doi.org/10.3892/or.2012.2179
MLA
Martinho, O., Simões, K., Longatto-Filho, A., Jacob, C. E., Zilberstein, B., Bresciani, C., Gama-Rodrigues, J., Cecconello, I., Alves, V., Reis, R. M."Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients". Oncology Reports 29.2 (2013): 690-696.
Chicago
Martinho, O., Simões, K., Longatto-Filho, A., Jacob, C. E., Zilberstein, B., Bresciani, C., Gama-Rodrigues, J., Cecconello, I., Alves, V., Reis, R. M."Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients". Oncology Reports 29, no. 2 (2013): 690-696. https://doi.org/10.3892/or.2012.2179