ZNF703 acts as an oncogene that promotes progression in gastric cancer

Yang,Gongli; Ma,Feng; Zhong,Muxiao; Fang,Lin; Peng,Yao; Xin,Xiaoming; Zhong,Jietao; Yuan,Fangfang; Gu,Hongxiang; Zhu,Wei; Zhang,Yali

doi:10.3892/or.2014.2997

2014-April Volume 31 Issue 4

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2014-April Volume 31 Issue 4

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Article

ZNF703 acts as an oncogene that promotes progression in gastric cancer

Authors:
- Gongli Yang
- Feng Ma
- Muxiao Zhong
- Lin Fang
- Yao Peng
- Xiaoming Xin
- Jietao Zhong
- Fangfang Yuan
- Hongxiang Gu
- Wei Zhu
- Yali Zhang
View Affiliations / Copyright

Affiliations: Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
Pages: 1877-1882
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Published online on: January 24, 2014

https://doi.org/10.3892/or.2014.2997
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Abstract

ZNF703, a member of the NET/Nlz family of zinc finger transcription factors, contributes to aspects of developmental growth and patterning across evolutionarily diverse species. ZNF703 has been identified as a novel oncogene in human breast cancer. In the present study, we investigated the expression of ZNF703 in gastric carcinoma and attempted to determine, using cell line models, its biological actions. Using immunohistochemistry, we analyzed the ZNF703 protein expression in 120 clinicopathologically characterized gastric cancer cases. Using RNA interference, we investigated the effects of ZNF703 depletion on tumor proliferation and metastasis in vitro. We found that ZNF703 was overexpressed in invasive gastric carcinoma tissues, and its expression levels were closely correlated with the depth of invasion, node metastasis and venous invasion. RNA interference-mediated silencing of the ZNF703 gene in SGC7901 cells inhibited cell proliferation and migration significantly. The results showed that ZNF703 acts as a gastric cancer oncogene and should be considered a therapeutic target for metastatic gastric cancer.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

ZNF703 acts as an oncogene that promotes progression in gastric cancer

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