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2014-April Volume 31 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

CCR9 as a prognostic marker and therapeutic target in hepatocellular carcinoma

  • Authors:
    • Zhenhai Zhang
    • Chengkun Qin
    • Yaguang Wu
    • Zhongxue Su
    • Guozhe Xian
    • Bo Hu
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Emergency, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China
  • Pages: 1629-1636
    |
    Published online on: January 24, 2014
       https://doi.org/10.3892/or.2014.2998
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Abstract

The chemokine receptor CCR9 was recently implicated in tumor biology. In the present study, our objective was to evaluate the clinical significance and potential role of CCR9 in hepatocellular carcinoma (HCC). CCR9 expression was detected by immunohistochemistry, quantitative PCR (qPCR) and western blotting in HCC patients. The prognostic significance of CCR9 expression was assessed. The functional roles of CCR9 in HCC were investigated using MTT, BrdU, colony formation assay and flow cytometry. CCR9 was significantly elevated in HCC tissue samples. High CCR9 expression was correlated with multiple tumor nodes, high Edmondson-Steiner grade and vascular invasion. Multivariate analysis showed that CCR9 expression was an independent prognostic factor for the overall survival (OS) of HCC patients. Further investigations revealed that ectopic expression of CCR9 enhanced cell proliferation and tumorigenicity in HCC cells, whereas CCR9 silencing impaired cell proliferation and tumorigenicity, which was mediated through downregulation of the cell cycle regulators p21, p27 as well as upregulation of cyclin D1. These results suggest that CCR9 can act as a novel prognostic marker and therapeutic target for HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Z, Qin C, Wu Y, Su Z, Xian G and Hu B: CCR9 as a prognostic marker and therapeutic target in hepatocellular carcinoma. Oncol Rep 31: 1629-1636, 2014.
APA
Zhang, Z., Qin, C., Wu, Y., Su, Z., Xian, G., & Hu, B. (2014). CCR9 as a prognostic marker and therapeutic target in hepatocellular carcinoma. Oncology Reports, 31, 1629-1636. https://doi.org/10.3892/or.2014.2998
MLA
Zhang, Z., Qin, C., Wu, Y., Su, Z., Xian, G., Hu, B."CCR9 as a prognostic marker and therapeutic target in hepatocellular carcinoma". Oncology Reports 31.4 (2014): 1629-1636.
Chicago
Zhang, Z., Qin, C., Wu, Y., Su, Z., Xian, G., Hu, B."CCR9 as a prognostic marker and therapeutic target in hepatocellular carcinoma". Oncology Reports 31, no. 4 (2014): 1629-1636. https://doi.org/10.3892/or.2014.2998
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, Qin C, Wu Y, Su Z, Xian G and Hu B: CCR9 as a prognostic marker and therapeutic target in hepatocellular carcinoma. Oncol Rep 31: 1629-1636, 2014.
APA
Zhang, Z., Qin, C., Wu, Y., Su, Z., Xian, G., & Hu, B. (2014). CCR9 as a prognostic marker and therapeutic target in hepatocellular carcinoma. Oncology Reports, 31, 1629-1636. https://doi.org/10.3892/or.2014.2998
MLA
Zhang, Z., Qin, C., Wu, Y., Su, Z., Xian, G., Hu, B."CCR9 as a prognostic marker and therapeutic target in hepatocellular carcinoma". Oncology Reports 31.4 (2014): 1629-1636.
Chicago
Zhang, Z., Qin, C., Wu, Y., Su, Z., Xian, G., Hu, B."CCR9 as a prognostic marker and therapeutic target in hepatocellular carcinoma". Oncology Reports 31, no. 4 (2014): 1629-1636. https://doi.org/10.3892/or.2014.2998
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