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2014-April Volume 31 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

Histone demethylase JARID1B promotes cell proliferation but is downregulated by N-Myc oncoprotein

  • Authors:
    • Lihong Zhang
    • Nicolas Sokolowski
    • Bernard Atmadibrata
    • Tao Liu
  • View Affiliations / Copyright

    Affiliations: Children's Cancer Institute Australia for Medical Research, Sydney, NSW 2031, Australia
  • Pages: 1935-1939
    |
    Published online on: January 30, 2014
       https://doi.org/10.3892/or.2014.3006
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Abstract

Myc oncoproteins induce tumor initiation and promote tumor progression by modulating gene transcription. We have previously shown that N-Myc represses gene transcription by recruiting histone deacetylases to Sp1-binding site-enriched regions of target gene promoters. The histone demethylase JARID1B plays a dual role in cancer. In the present study, we examined published microarray gene expression datasets and found that JARID1B was commonly repressed by Myc oncoproteins and histone deacetylases in cancer cell lines of various organ origins. Chromatin immunoprecipitation assays demonstrated that N-Myc repressed JARID1B expression by direct binding to the Sp1-binding site-enriched region of the JARID1B gene promoter, and cell proliferation assays showed that transcriptional repression of JARID1B reduced neuroblastoma cell proliferation. Our findings suggest that Myc-mediated transcriptional repression of JARID1B counterintuitively inhibits Myc-regulated cell proliferation and potentially tumorigenesis.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Sokolowski N, Atmadibrata B and Liu T: Histone demethylase JARID1B promotes cell proliferation but is downregulated by N-Myc oncoprotein. Oncol Rep 31: 1935-1939, 2014.
APA
Zhang, L., Sokolowski, N., Atmadibrata, B., & Liu, T. (2014). Histone demethylase JARID1B promotes cell proliferation but is downregulated by N-Myc oncoprotein. Oncology Reports, 31, 1935-1939. https://doi.org/10.3892/or.2014.3006
MLA
Zhang, L., Sokolowski, N., Atmadibrata, B., Liu, T."Histone demethylase JARID1B promotes cell proliferation but is downregulated by N-Myc oncoprotein". Oncology Reports 31.4 (2014): 1935-1939.
Chicago
Zhang, L., Sokolowski, N., Atmadibrata, B., Liu, T."Histone demethylase JARID1B promotes cell proliferation but is downregulated by N-Myc oncoprotein". Oncology Reports 31, no. 4 (2014): 1935-1939. https://doi.org/10.3892/or.2014.3006
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Sokolowski N, Atmadibrata B and Liu T: Histone demethylase JARID1B promotes cell proliferation but is downregulated by N-Myc oncoprotein. Oncol Rep 31: 1935-1939, 2014.
APA
Zhang, L., Sokolowski, N., Atmadibrata, B., & Liu, T. (2014). Histone demethylase JARID1B promotes cell proliferation but is downregulated by N-Myc oncoprotein. Oncology Reports, 31, 1935-1939. https://doi.org/10.3892/or.2014.3006
MLA
Zhang, L., Sokolowski, N., Atmadibrata, B., Liu, T."Histone demethylase JARID1B promotes cell proliferation but is downregulated by N-Myc oncoprotein". Oncology Reports 31.4 (2014): 1935-1939.
Chicago
Zhang, L., Sokolowski, N., Atmadibrata, B., Liu, T."Histone demethylase JARID1B promotes cell proliferation but is downregulated by N-Myc oncoprotein". Oncology Reports 31, no. 4 (2014): 1935-1939. https://doi.org/10.3892/or.2014.3006
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