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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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2014-April Volume 31 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Curcumin synergistically enhances the radiosensitivity of human oral squamous cell carcinoma via suppression of radiation-induced NF-κB activity

  • Authors:
    • I-Tsang Chiang
    • Yu-Chang Liu
    • Fei-Ting Hsu
    • Yi-Chun Chien
    • Chih-Hao K. Kao
    • Wuu-Jyh Lin
    • Jing-Gung Chung
    • Jeng-Jong Hwang

  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, R.O.C., Department of Radiopharmaceutical Production, Hualien Tzu Chi Hospital, Hualien, Taiwan, R.O.C., Division of Radioisotope, Institute of Nuclear Energy Research, Taoyuan, Taiwan, R.O.C., Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C.
  • Pages: 1729-1737
    |
    Published online on: January 31, 2014
       https://doi.org/10.3892/or.2014.3009
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Abstract

The anticancer effect of curcumin has been widely reported. However, whether curcumin can enhance the radiosensitivity of human oral squamous cell carcinoma (OSCC) remains to be elucidated. The aim of the present study was to evaluate the efficacy of curcumin combined with radiation against OSCC. SAS cells were transfected with the luciferase gene (luc) and named SAS/luc. NF-κB/DNA binding activity, the surviving fraction and NF-κB-regulated effector protein expression were determined by electrophoretic mobility shift assay, clonogenic survival assay and western blotting, respectively. The therapeutic efficacy was evaluated in SAS/luc tumor-bearing mice by caliper measurement and bioluminescence imaging. Curcumin enhanced SAS/luc radiosensitivity through the inhibition of radiation-induced NF-κB activity and expression of effector proteins both in vitro and in vivo. With 4 Gy or greater radiation doses, synergistic effects of curcumin were observed. The combination group (curcumin plus radiation) had significantly better tumor control compared with that of curcumin or radiation alone. No significant body weight change of mice was found throughout the entire study. In conclusion, curcumin is a radiosensitizer against OSCC with negligible toxicity.

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Copy and paste a formatted citation
Spandidos Publications style
Chiang I, Liu Y, Hsu F, Chien Y, Kao CK, Lin W, Chung J and Hwang J: Curcumin synergistically enhances the radiosensitivity of human oral squamous cell carcinoma via suppression of radiation-induced NF-κB activity. Oncol Rep 31: 1729-1737, 2014.
APA
Chiang, I., Liu, Y., Hsu, F., Chien, Y., Kao, C.K., Lin, W. ... Hwang, J. (2014). Curcumin synergistically enhances the radiosensitivity of human oral squamous cell carcinoma via suppression of radiation-induced NF-κB activity. Oncology Reports, 31, 1729-1737. https://doi.org/10.3892/or.2014.3009
MLA
Chiang, I., Liu, Y., Hsu, F., Chien, Y., Kao, C. K., Lin, W., Chung, J., Hwang, J."Curcumin synergistically enhances the radiosensitivity of human oral squamous cell carcinoma via suppression of radiation-induced NF-κB activity". Oncology Reports 31.4 (2014): 1729-1737.
Chicago
Chiang, I., Liu, Y., Hsu, F., Chien, Y., Kao, C. K., Lin, W., Chung, J., Hwang, J."Curcumin synergistically enhances the radiosensitivity of human oral squamous cell carcinoma via suppression of radiation-induced NF-κB activity". Oncology Reports 31, no. 4 (2014): 1729-1737. https://doi.org/10.3892/or.2014.3009
Copy and paste a formatted citation
x
Spandidos Publications style
Chiang I, Liu Y, Hsu F, Chien Y, Kao CK, Lin W, Chung J and Hwang J: Curcumin synergistically enhances the radiosensitivity of human oral squamous cell carcinoma via suppression of radiation-induced NF-κB activity. Oncol Rep 31: 1729-1737, 2014.
APA
Chiang, I., Liu, Y., Hsu, F., Chien, Y., Kao, C.K., Lin, W. ... Hwang, J. (2014). Curcumin synergistically enhances the radiosensitivity of human oral squamous cell carcinoma via suppression of radiation-induced NF-κB activity. Oncology Reports, 31, 1729-1737. https://doi.org/10.3892/or.2014.3009
MLA
Chiang, I., Liu, Y., Hsu, F., Chien, Y., Kao, C. K., Lin, W., Chung, J., Hwang, J."Curcumin synergistically enhances the radiosensitivity of human oral squamous cell carcinoma via suppression of radiation-induced NF-κB activity". Oncology Reports 31.4 (2014): 1729-1737.
Chicago
Chiang, I., Liu, Y., Hsu, F., Chien, Y., Kao, C. K., Lin, W., Chung, J., Hwang, J."Curcumin synergistically enhances the radiosensitivity of human oral squamous cell carcinoma via suppression of radiation-induced NF-κB activity". Oncology Reports 31, no. 4 (2014): 1729-1737. https://doi.org/10.3892/or.2014.3009
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