Diverse roles of miR-29 in cancer (Review)

  • Authors:
    • Hesong Jiang
    • Guang Zhang
    • Jun-Hua Wu
    • Chun-Ping Jiang
  • View Affiliations

  • Published online on: February 20, 2014     https://doi.org/10.3892/or.2014.3036
  • Pages: 1509-1516
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Abstract

microRNAs (miRNAs) are non-coding RNAs which have the capacity to regulate gene expression at the post-transcriptional level, and have emerging as key factors involved in cancer at all stages ranging from initiation to metastasis. In the present review, we summmarize the diverse roles of the microRNA-29 (miR-29) family in cancer. First, we present a concise introduction to the miR-29 family and the expression profile of miR-29 in various cancer types. We next highlight the upstream regulatory pathway of miR-29 and describe the relationship between miR-29 and cancer in detail. As a tumor suppressor, miR-29 restrains cancer progression by promoting tumor cell apoptosis, by suppressing DNA methylation of tumor-suppressor genes, by reducing proliferation of tumors and by increasing chemosensitivity. However, as a tumor promoter, miR-29 mediates epithelial-mesenchymal transition (EMT) and promotes metastasis in breast cancer and colon cancer. Finally, we suggest that miR-29 represents a novel diagnostic and prognostic biomarker or a therapeutic target for cancer. Our review highlights the diverse relationship between miR-29 and cancer (particularly digestive system neoplasms). Further research of miR-29 in cancer is warranted.
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2014-April
Volume 31 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Jiang H, Zhang G, Wu J and Jiang C: Diverse roles of miR-29 in cancer (Review). Oncol Rep 31: 1509-1516, 2014
APA
Jiang, H., Zhang, G., Wu, J., & Jiang, C. (2014). Diverse roles of miR-29 in cancer (Review). Oncology Reports, 31, 1509-1516. https://doi.org/10.3892/or.2014.3036
MLA
Jiang, H., Zhang, G., Wu, J., Jiang, C."Diverse roles of miR-29 in cancer (Review)". Oncology Reports 31.4 (2014): 1509-1516.
Chicago
Jiang, H., Zhang, G., Wu, J., Jiang, C."Diverse roles of miR-29 in cancer (Review)". Oncology Reports 31, no. 4 (2014): 1509-1516. https://doi.org/10.3892/or.2014.3036