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Review

KIAA1199 and its biological role in human cancer and cancer cells (Review)

  • Authors:
    • Yongsheng Zhang
    • Shuqin Jia
    • Wen G. Jiang
  • View Affiliations / Copyright

    Affiliations: Laboratory of Surgery, The Affiliated Hospital, Inner Mongolia Medical University, Hohhot 010050, P.R. China, Cardiff University-Peking University Joint Cancer Institute, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK
  • Pages: 1503-1508
    |
    Published online on: February 20, 2014
       https://doi.org/10.3892/or.2014.3038
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Abstract

KIAA1199 is a gene included in the Human Unidentified Gene-Encoded (HUGE) large protein database which contains more than 2,400 members identified in the Kazusa cDNA sequencing project. Early studies described KIAA1199 as an inner ear-specific protein in which 3 point mutations were found to be associated with non‑syndromic hearing loss. Recently, KIAA1199 has been found to play a central role in hyaluronan binding and depolymerisation, and a small number of studies indicate its senescence/apoptosis-promoting role. An increasing body of evidence suggests its involvement in cancer progression, metastasis and poor prognosis of patients with cancer as determined in clinical studies. It has also been shown, in vitro, that KIAA1199 influences the proliferation, adhesion, motility, invasiveness and epithelial-to-mesenchymal transition of cancer cells. Pathway signalling analysis found that KIAA1199 is a likely target gene of the Wnt/β-catenin signalling pathway. Therefore, KIAA1199 may be a new and prospective target for cancer therapy, although further in vitro and in vivo investigations are required.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Jia S and Jiang WG: KIAA1199 and its biological role in human cancer and cancer cells (Review). Oncol Rep 31: 1503-1508, 2014.
APA
Zhang, Y., Jia, S., & Jiang, W.G. (2014). KIAA1199 and its biological role in human cancer and cancer cells (Review). Oncology Reports, 31, 1503-1508. https://doi.org/10.3892/or.2014.3038
MLA
Zhang, Y., Jia, S., Jiang, W. G."KIAA1199 and its biological role in human cancer and cancer cells (Review)". Oncology Reports 31.4 (2014): 1503-1508.
Chicago
Zhang, Y., Jia, S., Jiang, W. G."KIAA1199 and its biological role in human cancer and cancer cells (Review)". Oncology Reports 31, no. 4 (2014): 1503-1508. https://doi.org/10.3892/or.2014.3038
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Jia S and Jiang WG: KIAA1199 and its biological role in human cancer and cancer cells (Review). Oncol Rep 31: 1503-1508, 2014.
APA
Zhang, Y., Jia, S., & Jiang, W.G. (2014). KIAA1199 and its biological role in human cancer and cancer cells (Review). Oncology Reports, 31, 1503-1508. https://doi.org/10.3892/or.2014.3038
MLA
Zhang, Y., Jia, S., Jiang, W. G."KIAA1199 and its biological role in human cancer and cancer cells (Review)". Oncology Reports 31.4 (2014): 1503-1508.
Chicago
Zhang, Y., Jia, S., Jiang, W. G."KIAA1199 and its biological role in human cancer and cancer cells (Review)". Oncology Reports 31, no. 4 (2014): 1503-1508. https://doi.org/10.3892/or.2014.3038
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