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Article

High MMP-21 expression in metastatic lymph nodes predicts unfavorable overall survival for oral squamous cell carcinoma patients with lymphatic metastasis

  • Authors:
    • Yinfei Pu
    • Lin Wang
    • Huanhuan Wu
    • Zhien Feng
    • Yixiang Wang
    • Chuanbin Guo
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Haidian, Beijing 100081, P.R. China, Central Laboratory, Peking University School and Hospital of Stomatology, Haidian, Beijing 100081, P.R. China
  • Pages: 2644-2650
    |
    Published online on: April 2, 2014
       https://doi.org/10.3892/or.2014.3124
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Abstract

The aim of the present study was to examine the clinical significance of lymph node metastatic (LNM) foci in predicting the overall survival of oral squamous cell carcinoma (OSCC) patients with LNM. MMP-21 was screened based on the LNM animal model of OSCC. Then four proteins, matrix metalloproteinase (MMP)-2, MMP-21, vascular endothelial growth factor (VEGF)-C and VEGF receptor (VEGFR)-3 were examined by immunohistochemistry in 63 OSCC specimens, including the primary tumors (PTs) and the corresponding LNM foci. The expression levels between the PTs and LNM foci were compared by Wilcoxon paired test. Relationships between expression of the four proteins and patient overall survival were assessed by Kaplan-Meier based on the median of the labeling index. The Cox proportional hazards model was used to assess the relative hazard factors. MMP-21 and VEGF-C expression levels were higher in the LNM foci than levels in the PTs. Results showed that MMP-2 and VEGF-C expression levels in the PTs and MMP-2, MMP-21 and VEGF-C expression in the LNM foci correlated with the overall survival of the OSCC patients with lymphatic metastasis. MMP-21 expression level in the LNM foci was the most reliable predictor among all the tested factors. These results suggest that high MMP-21 expression in LNM foci can be used to predict survival in OSCC patients with LNM. Characteristics of LNM foci may be more reliable than PT characteristics in predicting the overall survival of OSCC patients with lymphatic metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Pu Y, Wang L, Wu H, Feng Z, Wang Y and Guo C: High MMP-21 expression in metastatic lymph nodes predicts unfavorable overall survival for oral squamous cell carcinoma patients with lymphatic metastasis. Oncol Rep 31: 2644-2650, 2014.
APA
Pu, Y., Wang, L., Wu, H., Feng, Z., Wang, Y., & Guo, C. (2014). High MMP-21 expression in metastatic lymph nodes predicts unfavorable overall survival for oral squamous cell carcinoma patients with lymphatic metastasis. Oncology Reports, 31, 2644-2650. https://doi.org/10.3892/or.2014.3124
MLA
Pu, Y., Wang, L., Wu, H., Feng, Z., Wang, Y., Guo, C."High MMP-21 expression in metastatic lymph nodes predicts unfavorable overall survival for oral squamous cell carcinoma patients with lymphatic metastasis". Oncology Reports 31.6 (2014): 2644-2650.
Chicago
Pu, Y., Wang, L., Wu, H., Feng, Z., Wang, Y., Guo, C."High MMP-21 expression in metastatic lymph nodes predicts unfavorable overall survival for oral squamous cell carcinoma patients with lymphatic metastasis". Oncology Reports 31, no. 6 (2014): 2644-2650. https://doi.org/10.3892/or.2014.3124
Copy and paste a formatted citation
x
Spandidos Publications style
Pu Y, Wang L, Wu H, Feng Z, Wang Y and Guo C: High MMP-21 expression in metastatic lymph nodes predicts unfavorable overall survival for oral squamous cell carcinoma patients with lymphatic metastasis. Oncol Rep 31: 2644-2650, 2014.
APA
Pu, Y., Wang, L., Wu, H., Feng, Z., Wang, Y., & Guo, C. (2014). High MMP-21 expression in metastatic lymph nodes predicts unfavorable overall survival for oral squamous cell carcinoma patients with lymphatic metastasis. Oncology Reports, 31, 2644-2650. https://doi.org/10.3892/or.2014.3124
MLA
Pu, Y., Wang, L., Wu, H., Feng, Z., Wang, Y., Guo, C."High MMP-21 expression in metastatic lymph nodes predicts unfavorable overall survival for oral squamous cell carcinoma patients with lymphatic metastasis". Oncology Reports 31.6 (2014): 2644-2650.
Chicago
Pu, Y., Wang, L., Wu, H., Feng, Z., Wang, Y., Guo, C."High MMP-21 expression in metastatic lymph nodes predicts unfavorable overall survival for oral squamous cell carcinoma patients with lymphatic metastasis". Oncology Reports 31, no. 6 (2014): 2644-2650. https://doi.org/10.3892/or.2014.3124
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