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Review Open Access

Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review)

  • Authors:
    • Hilda Jiménez-Wences
    • Oscar Peralta-Zaragoza
    • Gloria Fernández-Tilapa
  • View Affiliations / Copyright

    Affiliations: Clinical Research Laboratory, Academic Unit of Biological Chemical Sciences, Guerrero Autonomous University, Colonia Haciendita, Chilpancingo, Guerrero 39070, Mexico, Direction of Chronic Infections and Cancer, Research Center for Infectious Diseases, National Institute of Public Health, Cerrada los Pinos y Caminera, Colonia Santa María Ahuacatitlán, Cuernavaca, Morelos 62100, Mexico
    Copyright: © Jiménez-Wences et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 2467-2476
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    Published online on: April 16, 2014
       https://doi.org/10.3892/or.2014.3142
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Abstract

Cancer is a complex disease caused by genetic and epigenetic abnormalities that affect gene expression. The progression from precursor lesions to invasive cervical cancer is influenced by persistent human papilloma virus (HPV) infection, which induces changes in the host genome and epigenome. Epigenetic alterations, such as aberrant miRNA expression and changes in DNA methylation status, favor the expression of oncogenes and the silencing of tumor-suppressor genes. Given that some miRNA genes can be regulated through epigenetic mechanisms, it has been proposed that alterations in the methylation status of miRNA promoters could be the driving mechanism behind their aberrant expression in cervical cancer. For these reasons, we assessed the relationship among HPV infection, cellular DNA methylation and miRNA expression. We conclude that alterations in the methylation status of protein-coding genes and various miRNA genes are influenced by HPV infection, the viral genotype, the physical state of the viral DNA, and viral oncogenic risk. Furthermore, HPV induces deregulation of miRNA expression, particularly at loci near fragile sites. This deregulation occurs through the E6 and E7 proteins, which target miRNA transcription factors such as p53.
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Copy and paste a formatted citation
Spandidos Publications style
Jiménez-Wences H, Peralta-Zaragoza O and Fernández-Tilapa G: Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review). Oncol Rep 31: 2467-2476, 2014.
APA
Jiménez-Wences, H., Peralta-Zaragoza, O., & Fernández-Tilapa, G. (2014). Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review). Oncology Reports, 31, 2467-2476. https://doi.org/10.3892/or.2014.3142
MLA
Jiménez-Wences, H., Peralta-Zaragoza, O., Fernández-Tilapa, G."Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review)". Oncology Reports 31.6 (2014): 2467-2476.
Chicago
Jiménez-Wences, H., Peralta-Zaragoza, O., Fernández-Tilapa, G."Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review)". Oncology Reports 31, no. 6 (2014): 2467-2476. https://doi.org/10.3892/or.2014.3142
Copy and paste a formatted citation
x
Spandidos Publications style
Jiménez-Wences H, Peralta-Zaragoza O and Fernández-Tilapa G: Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review). Oncol Rep 31: 2467-2476, 2014.
APA
Jiménez-Wences, H., Peralta-Zaragoza, O., & Fernández-Tilapa, G. (2014). Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review). Oncology Reports, 31, 2467-2476. https://doi.org/10.3892/or.2014.3142
MLA
Jiménez-Wences, H., Peralta-Zaragoza, O., Fernández-Tilapa, G."Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review)". Oncology Reports 31.6 (2014): 2467-2476.
Chicago
Jiménez-Wences, H., Peralta-Zaragoza, O., Fernández-Tilapa, G."Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review)". Oncology Reports 31, no. 6 (2014): 2467-2476. https://doi.org/10.3892/or.2014.3142
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