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Article

Shikonin blocks migration and invasion of human breast cancer cells through inhibition of matrix metalloproteinase-9 activation

  • Authors:
    • Soon Young Jang
    • Jae Koan Lee
    • Eun Hyang Jang
    • Seo Young Jeong
    • Jong-Ho Kim
  • View Affiliations / Copyright

    Affiliations: College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea, Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul 130-701, Republic of Korea
  • Pages: 2827-2833
    |
    Published online on: April 25, 2014
       https://doi.org/10.3892/or.2014.3159
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Abstract

Shikonin, a natural naphthoquinone isolated from a traditional Chinese medicinal herb, has been reported to promote tumor cell death. However, there are few reports concerning its effect on metastasis-related cell invasion and migration behavior. In the present study, we investigated the effect of shikonin on human breast cancer invasion and migration. We found that shikonin inhibited phorbol 12-myristate 13-acetate (PMA)-induced cell migration and invasion in MCF-7 breast cancer cells, which was correlated with modulation of matrix metalloproteinase-9 (MMP-9) through suppression of both expression and proteolytic and promoter activity. We also found that shikonin inhibited both MMP-9 expression and promoter activity in MDA-MB‑231 cells with high metastatic potential. These results indicated that shikonin induces the suppression of migration and invasion through modulation of MMP-9 in human breast cancer cells. Therefore, shikonin may be a potential anticancer drug for human breast cancer therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Jang SY, Lee JK, Jang EH, Jeong SY and Kim J: Shikonin blocks migration and invasion of human breast cancer cells through inhibition of matrix metalloproteinase-9 activation. Oncol Rep 31: 2827-2833, 2014.
APA
Jang, S.Y., Lee, J.K., Jang, E.H., Jeong, S.Y., & Kim, J. (2014). Shikonin blocks migration and invasion of human breast cancer cells through inhibition of matrix metalloproteinase-9 activation. Oncology Reports, 31, 2827-2833. https://doi.org/10.3892/or.2014.3159
MLA
Jang, S. Y., Lee, J. K., Jang, E. H., Jeong, S. Y., Kim, J."Shikonin blocks migration and invasion of human breast cancer cells through inhibition of matrix metalloproteinase-9 activation". Oncology Reports 31.6 (2014): 2827-2833.
Chicago
Jang, S. Y., Lee, J. K., Jang, E. H., Jeong, S. Y., Kim, J."Shikonin blocks migration and invasion of human breast cancer cells through inhibition of matrix metalloproteinase-9 activation". Oncology Reports 31, no. 6 (2014): 2827-2833. https://doi.org/10.3892/or.2014.3159
Copy and paste a formatted citation
x
Spandidos Publications style
Jang SY, Lee JK, Jang EH, Jeong SY and Kim J: Shikonin blocks migration and invasion of human breast cancer cells through inhibition of matrix metalloproteinase-9 activation. Oncol Rep 31: 2827-2833, 2014.
APA
Jang, S.Y., Lee, J.K., Jang, E.H., Jeong, S.Y., & Kim, J. (2014). Shikonin blocks migration and invasion of human breast cancer cells through inhibition of matrix metalloproteinase-9 activation. Oncology Reports, 31, 2827-2833. https://doi.org/10.3892/or.2014.3159
MLA
Jang, S. Y., Lee, J. K., Jang, E. H., Jeong, S. Y., Kim, J."Shikonin blocks migration and invasion of human breast cancer cells through inhibition of matrix metalloproteinase-9 activation". Oncology Reports 31.6 (2014): 2827-2833.
Chicago
Jang, S. Y., Lee, J. K., Jang, E. H., Jeong, S. Y., Kim, J."Shikonin blocks migration and invasion of human breast cancer cells through inhibition of matrix metalloproteinase-9 activation". Oncology Reports 31, no. 6 (2014): 2827-2833. https://doi.org/10.3892/or.2014.3159
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