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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Protein tyrosine kinase 7 plays a tumor suppressor role by inhibiting ERK and AKT phosphorylation in lung cancer

  • Authors:
    • Ji-Hee Kim
    • Junhye Kwon
    • Hae Won Lee
    • Moon Chul Kang
    • Hyeon‑Joon Yoon
    • Seung-Taek Lee
    • Jong Ho Park
  • View Affiliations / Copyright

    Affiliations: Department of Translational Research, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, Republic of Korea, Department of Thoracic Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, Republic of Korea, Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Republic of Korea
  • Pages: 2708-2712
    |
    Published online on: April 30, 2014
       https://doi.org/10.3892/or.2014.3164
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Abstract

Protein tyrosine kinase 7 (PTK7) is a catalytically inactive receptor tyrosine kinase that is also known as colon carcinoma kinase-4 (CCK-4). Recent reports have shown that PTK7 plays an important role in carcinogenesis, and it is known to be upregulated in gastric, colon and esophageal cancer, as well as in liposarcoma. However, the role of PTK7 in lung cancer has not been investigated. The aim of the present study was to investigate the expression levels and the role of PTK7 in lung cancer. We found that PTK7 expression was downregulated at the mRNA as well as protein levels in human lung squamous cell carcinoma (LSCC). Upon investigation of the functional role of PTK7 in LSCC, we found that overexpression of PTK7 in LSCC cells resulted in inhibition of cell proliferation, invasion and migration. Furthermore, we confirmed that these phenotypic changes are associated with the inactivation of AKT and ERK. Our findings suggest that PTK7 has different oncogenic roles in organs and target tumors.
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Copy and paste a formatted citation
Spandidos Publications style
Kim J, Kwon J, Lee HW, Kang MC, Yoon HJ, Lee S and Park JH: Protein tyrosine kinase 7 plays a tumor suppressor role by inhibiting ERK and AKT phosphorylation in lung cancer. Oncol Rep 31: 2708-2712, 2014.
APA
Kim, J., Kwon, J., Lee, H.W., Kang, M.C., Yoon, H., Lee, S., & Park, J.H. (2014). Protein tyrosine kinase 7 plays a tumor suppressor role by inhibiting ERK and AKT phosphorylation in lung cancer. Oncology Reports, 31, 2708-2712. https://doi.org/10.3892/or.2014.3164
MLA
Kim, J., Kwon, J., Lee, H. W., Kang, M. C., Yoon, H., Lee, S., Park, J. H."Protein tyrosine kinase 7 plays a tumor suppressor role by inhibiting ERK and AKT phosphorylation in lung cancer". Oncology Reports 31.6 (2014): 2708-2712.
Chicago
Kim, J., Kwon, J., Lee, H. W., Kang, M. C., Yoon, H., Lee, S., Park, J. H."Protein tyrosine kinase 7 plays a tumor suppressor role by inhibiting ERK and AKT phosphorylation in lung cancer". Oncology Reports 31, no. 6 (2014): 2708-2712. https://doi.org/10.3892/or.2014.3164
Copy and paste a formatted citation
x
Spandidos Publications style
Kim J, Kwon J, Lee HW, Kang MC, Yoon HJ, Lee S and Park JH: Protein tyrosine kinase 7 plays a tumor suppressor role by inhibiting ERK and AKT phosphorylation in lung cancer. Oncol Rep 31: 2708-2712, 2014.
APA
Kim, J., Kwon, J., Lee, H.W., Kang, M.C., Yoon, H., Lee, S., & Park, J.H. (2014). Protein tyrosine kinase 7 plays a tumor suppressor role by inhibiting ERK and AKT phosphorylation in lung cancer. Oncology Reports, 31, 2708-2712. https://doi.org/10.3892/or.2014.3164
MLA
Kim, J., Kwon, J., Lee, H. W., Kang, M. C., Yoon, H., Lee, S., Park, J. H."Protein tyrosine kinase 7 plays a tumor suppressor role by inhibiting ERK and AKT phosphorylation in lung cancer". Oncology Reports 31.6 (2014): 2708-2712.
Chicago
Kim, J., Kwon, J., Lee, H. W., Kang, M. C., Yoon, H., Lee, S., Park, J. H."Protein tyrosine kinase 7 plays a tumor suppressor role by inhibiting ERK and AKT phosphorylation in lung cancer". Oncology Reports 31, no. 6 (2014): 2708-2712. https://doi.org/10.3892/or.2014.3164
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