Bioinformatics screening regarding herbal components that targetedly regulate the function of tumour-associated macrophages

  • Authors:
    • Bo Gao
    • Yingmei Wang
    • Yan Qiu
    • Weiliang  Xia
    • Xianzhi  Meng
    • Ming  Lu
    • Weihui  Zhang
    • Xin  Qiao
    • Yingmei Zhang
    • Dongbo Xue
  • View Affiliations

  • Published online on: May 23, 2014     https://doi.org/10.3892/or.2014.3217
  • Pages: 309-317
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Abstract

As an important component of tumour stroma, tumour-associated macrophages (TAMs) promote tumour development and progression. Herbs have been increasingly used in anticancer therapies due to their wide-ranging anticancer effects and minor side-effects. However, no herb-based treatments targeting TAMs have yet been proposed. To address this issue, screening using modular analysis bioinformatics techniques found 6 core functional modules for TAMs that contain 46 total genes. Moreover, 15 potential new anticancer drugs that regulate the genes in the 6 core modules were identified through bioinformatics techniques and Fisher's exact test. Our results provide a new research avenue for targeting TAMs in anticancer therapies.

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July-2014
Volume 32 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Gao B, Wang Y, Qiu Y, Xia W, Meng X, Lu M, Zhang W, Qiao X, Zhang Y, Xue D, Xue D, et al: Bioinformatics screening regarding herbal components that targetedly regulate the function of tumour-associated macrophages. Oncol Rep 32: 309-317, 2014.
APA
Gao, B., Wang, Y., Qiu, Y., Xia, W., Meng, X., Lu, M. ... Xue, D. (2014). Bioinformatics screening regarding herbal components that targetedly regulate the function of tumour-associated macrophages. Oncology Reports, 32, 309-317. https://doi.org/10.3892/or.2014.3217
MLA
Gao, B., Wang, Y., Qiu, Y., Xia, W., Meng, X., Lu, M., Zhang, W., Qiao, X., Zhang, Y., Xue, D."Bioinformatics screening regarding herbal components that targetedly regulate the function of tumour-associated macrophages". Oncology Reports 32.1 (2014): 309-317.
Chicago
Gao, B., Wang, Y., Qiu, Y., Xia, W., Meng, X., Lu, M., Zhang, W., Qiao, X., Zhang, Y., Xue, D."Bioinformatics screening regarding herbal components that targetedly regulate the function of tumour-associated macrophages". Oncology Reports 32, no. 1 (2014): 309-317. https://doi.org/10.3892/or.2014.3217