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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April-2015 Volume 33 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Induction and mechanism of HeLa cell apoptosis by 9-oxo‑10, 11-dehydroageraphorone from Eupatorium adenophorum

  • Authors:
    • Fei Liao
    • Yanchun Hu
    • Lei Wu
    • Hui Tan
    • Biao Luo
    • Yajun He
    • Yan Qiao
    • Quan Mo
    • Ya Wang
    • Zhicai Zuo
    • Junliang Deng
    • Yahui Wei

  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Sichuan, Wenjiang 611130, P.R. China, Key Laboratory of Resource Biology and Biotechnology in Western China, School of Life Science, Northwest University, Xi'an 710069, P.R. China
  • Pages: 1823-1827
    |
    Published online on: February 2, 2015
       https://doi.org/10.3892/or.2015.3778
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Abstract

9-Oxo-10, 11-dehydroageraphorone (euptox A), a cadenine sesquiterpene, is the main toxin from Eupatorium adenophorum. The aim of the present study was to examine the induction and mechanism of HeLa cell apoptosis by euptox A. The apoptosis‑inducing effect of the euptox A on HeLa cells was examined by MTT assay. The underlying mechanism was analyzed by flow cytometry and quantitative PCR. Flow cytometry results suggested that euptox A effectively inhibited the proliferation of HeLa cells, arrested the cell cycle transition from S to G2/M phase, did not continue to complete the cell cycle activity (mainly from 4 times and mitosis), and induced cell proliferation. The RT-qPCR detection results showed that euptox A induced apoptosis by improving the gene expression level of apoptotic proteases such as caspase-10 in HeLa cells. Its mechanism of action was associated with the upregulation of apoptotic gene expression and arresting of the cell cycle.

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Copy and paste a formatted citation
Spandidos Publications style
Liao F, Hu Y, Wu L, Tan H, Luo B, He Y, Qiao Y, Mo Q, Wang Y, Zuo Z, Zuo Z, et al: Induction and mechanism of HeLa cell apoptosis by 9-oxo‑10, 11-dehydroageraphorone from Eupatorium adenophorum. Oncol Rep 33: 1823-1827, 2015.
APA
Liao, F., Hu, Y., Wu, L., Tan, H., Luo, B., He, Y. ... Wei, Y. (2015). Induction and mechanism of HeLa cell apoptosis by 9-oxo‑10, 11-dehydroageraphorone from Eupatorium adenophorum. Oncology Reports, 33, 1823-1827. https://doi.org/10.3892/or.2015.3778
MLA
Liao, F., Hu, Y., Wu, L., Tan, H., Luo, B., He, Y., Qiao, Y., Mo, Q., Wang, Y., Zuo, Z., Deng, J., Wei, Y."Induction and mechanism of HeLa cell apoptosis by 9-oxo‑10, 11-dehydroageraphorone from Eupatorium adenophorum". Oncology Reports 33.4 (2015): 1823-1827.
Chicago
Liao, F., Hu, Y., Wu, L., Tan, H., Luo, B., He, Y., Qiao, Y., Mo, Q., Wang, Y., Zuo, Z., Deng, J., Wei, Y."Induction and mechanism of HeLa cell apoptosis by 9-oxo‑10, 11-dehydroageraphorone from Eupatorium adenophorum". Oncology Reports 33, no. 4 (2015): 1823-1827. https://doi.org/10.3892/or.2015.3778
Copy and paste a formatted citation
x
Spandidos Publications style
Liao F, Hu Y, Wu L, Tan H, Luo B, He Y, Qiao Y, Mo Q, Wang Y, Zuo Z, Zuo Z, et al: Induction and mechanism of HeLa cell apoptosis by 9-oxo‑10, 11-dehydroageraphorone from Eupatorium adenophorum. Oncol Rep 33: 1823-1827, 2015.
APA
Liao, F., Hu, Y., Wu, L., Tan, H., Luo, B., He, Y. ... Wei, Y. (2015). Induction and mechanism of HeLa cell apoptosis by 9-oxo‑10, 11-dehydroageraphorone from Eupatorium adenophorum. Oncology Reports, 33, 1823-1827. https://doi.org/10.3892/or.2015.3778
MLA
Liao, F., Hu, Y., Wu, L., Tan, H., Luo, B., He, Y., Qiao, Y., Mo, Q., Wang, Y., Zuo, Z., Deng, J., Wei, Y."Induction and mechanism of HeLa cell apoptosis by 9-oxo‑10, 11-dehydroageraphorone from Eupatorium adenophorum". Oncology Reports 33.4 (2015): 1823-1827.
Chicago
Liao, F., Hu, Y., Wu, L., Tan, H., Luo, B., He, Y., Qiao, Y., Mo, Q., Wang, Y., Zuo, Z., Deng, J., Wei, Y."Induction and mechanism of HeLa cell apoptosis by 9-oxo‑10, 11-dehydroageraphorone from Eupatorium adenophorum". Oncology Reports 33, no. 4 (2015): 1823-1827. https://doi.org/10.3892/or.2015.3778
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