Serum and glucocorticoid-regulated kinase 1 (SGK1) is a predictor of poor prognosis in non-small cell lung cancer, and its dynamic pattern following treatment with SGK1 inhibitor and γ-ray irradiation was elucidated

  • Authors:
    • Zhiyuan Tang
    • Qin Shen
    • Hao Xie
    • Zhu Zhou
    • Guanglin Shi
    • Caixin Zhang
    • Anaz Mohammed
    • Yi Wu
    • Songshi Ni
    • Xiaoyu Zhou
  • View Affiliations

  • Published online on: January 3, 2018     https://doi.org/10.3892/or.2018.6181
  • Pages:1505-1515
Metrics: HTML 0 views | PDF 0 views     Cited By (CrossRef): 0 citations

Abstract

The tumor suppressor gene p53 and its dynamic patterns have caused widespread attention in the field of cancer research. Serum and glucocorticoid-regulated kinase 1 (SGK1) with features of serine/threonine kinase activity, which also contributes to the structural and functional similarities with the AKT family of kinases, is a key enzyme in the regulation of immune responses in tumor cells, and SGK1 was noted to be expressed in close relation to p53 protein levels, and there exists a negative feedback pathway between intracellular SGK1 and p53. Noteworthy, SGK1 was detected to play a role in the development of resistance to cancer chemotherapy. In this study, we demonstrated that high SGK1 expression had strong prognostic value for reduced overall survival in NSCLC patients. Detection of SGK1 collectively was helpful to predict the prognosis of NSCLC. We also identified the expression level of SGK1 and the p53 pathway including downstream apoptotic proteins under the stimulation of γ-radiation and SGK1 inhibitor GSK650394, which presented a series of dynamic fluctuations. Our results suggest that SGK1 dynamics could play an important role in cell signaling, which is capable of directly influencing NSCLC cellular fate decisions.

Related Articles

Journal Cover

March 2018
Volume 39 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Tang, Z., Shen, Q., Xie, H., Zhou, Z., Shi, G., Zhang, C. ... Zhou, X. (2018). Serum and glucocorticoid-regulated kinase 1 (SGK1) is a predictor of poor prognosis in non-small cell lung cancer, and its dynamic pattern following treatment with SGK1 inhibitor and γ-ray irradiation was elucidated. Oncology Reports, 39, 1505-1515. https://doi.org/10.3892/or.2018.6181
MLA
Tang, Z., Shen, Q., Xie, H., Zhou, Z., Shi, G., Zhang, C., Mohammed, A., Wu, Y., Ni, S., Zhou, X."Serum and glucocorticoid-regulated kinase 1 (SGK1) is a predictor of poor prognosis in non-small cell lung cancer, and its dynamic pattern following treatment with SGK1 inhibitor and γ-ray irradiation was elucidated". Oncology Reports 39.3 (2018): 1505-1515.
Chicago
Tang, Z., Shen, Q., Xie, H., Zhou, Z., Shi, G., Zhang, C., Mohammed, A., Wu, Y., Ni, S., Zhou, X."Serum and glucocorticoid-regulated kinase 1 (SGK1) is a predictor of poor prognosis in non-small cell lung cancer, and its dynamic pattern following treatment with SGK1 inhibitor and γ-ray irradiation was elucidated". Oncology Reports 39, no. 3 (2018): 1505-1515. https://doi.org/10.3892/or.2018.6181