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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
March-2018 Volume 39 Issue 3

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

A double-edged function of DDX3, as an oncogene or tumor suppressor, in cancer progression (Review)

Yu He, Dan Zhang, Yanfang Yang, Xixi Wang, Xinyu Zhao, Peng Zhang, Hongxia Zhu, Ningzhi Xu, Shufang Liang
Pages: 883-892
Published online on: 09 January 2018

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Review

Application of multifunctional nanomaterials in cancer vaccines (Review)

Biao Fu, Xiaomei Huang, Jiaqi Deng, Daijiao Gu, Qibing Mei, Mingming Deng, Shixiao Tang, Muhan Lü
Pages: 893-900
Published online on: 10 January 2018

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Review

Mechanisms of the CDK4/6 inhibitor palbociclib (PD 0332991) and its future application in cancer treatment (Review)

Minghui Liu, Hongyu Liu, Jun Chen
Pages: 901-911
Published online on: 19 January 2018

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Article Open Access

Inactivation of DNA-PK by knockdown DNA-PKcs or NU7441 impairs non-homologous end-joining of radiation-induced double strand break repair

Jun Dong, Yufeng Ren, Tian Zhang, Zhenyu Wang, Clifton C. Ling, Gloria C. Li, Fuqiu He, Chengtao Wang, Bixiu Wen
Pages: 912-920
Published online on: 16 January 2018

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Article Open Access

Effects of diphyllin as a novel V-ATPase inhibitor on TE-1 and ECA-109 cells

Haijiao Chen, Pengfei Liu, Ting Zhang, Yi Gao, Yingdi Zhang, Xiuyun Shen, Xiao Li, Weidong Shen
Pages: 921-928
Published online on: 04 January 2018

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Article Open Access

Meta-analysis of mRNA expression profiles to identify differentially expressed genes in lung adenocarcinoma tissue from smokers and non-smokers

Xiaona He, Cheng Zhang, Chao Shi, Quqin Lu
Pages: 929-938
Published online on: 08 January 2018

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Article Open Access

Knockdown of hnRNP A2/B1 inhibits cell proliferation, invasion and cell cycle triggering apoptosis in cervical cancer via PI3K/AKT signaling pathway

Xiang Shi, Li Ran, Yao Liu, Shu‑Huai Zhong, Ping‑Ping Zhou, Ming‑Xin Liao, Wen Fang
Pages: 939-950
Published online on: 05 January 2018

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Article Open Access

CircDOCK1 suppresses cell apoptosis via inhibition of miR‑196a‑5p by targeting BIRC3 in OSCC

Liping Wang, Yongxiang Wei, Yongyong Yan, Haiyan Wang, Jiantin Yang, Zhichao Zheng, Jun Zha, Peng Bo, Yinghua Tang, Xueqi Guo, Weihong Chen, Xinxin Zhu, Linhu Ge
Pages: 951-966
Published online on: 28 December 2017

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Article Open Access

Chronic oxymatrine treatment induces resistance and epithelial‑mesenchymal transition through targeting the long non-coding RNA MALAT1 in colorectal cancer cells Retraction in /10.3892/or.2024.8732

Yibai Xiong, Jun Wang, Huirong Zhu, Lingshuang Liu, Yi Jiang
Pages: 967-976
Published online on: 10 January 2018

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Article Open Access

hsa-miR-212 modulates the radiosensitivity of glioma cells by targeting BRCA1 Retraction in /10.3892/or.2024.8818

Xin He, Saijun Fan
Pages: 977-984
Published online on: 15 December 2017

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Article Open Access

Bcl-2 overexpression reduces cisplatin cytotoxicity by decreasing ER-mitochondrial Ca2+ signaling in SKOV3 cells

Lu Xu, Qi Xie, Ling Qi, Chunyan Wang, Na Xu, Weimin Liu, Yang Yu, Songyan Li, Ye Xu
Pages: 985-992
Published online on: 19 December 2017

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Article Open Access

DNA methylation enzyme inhibitor RG108 suppresses the radioresistance of esophageal cancer

Yao Ou, Quan Zhang, Yiting Tang, Zhonghua Lu, Xujing Lu, Xifa Zhou, Changmin Liu
Pages: 993-1002
Published online on: 11 January 2018

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Article Open Access

Bioinformatic identification of chemoresistance-associated microRNAs in breast cancer based on microarray data

Ya-Wen Wang, Weiguo Zhang, Rong Ma
Pages: 1003-1010
Published online on: 10 January 2018

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Article Open Access

Actin-capping protein CapG is associated with prognosis, proliferation and metastasis in human glioma

Da-Peng Yun, Yu-Qi Wang, De-Long Meng, Yuan-Yuan Ji, Ju-Xiang Chen, Hong-Yan Chen, Da-Ru Lu
Pages: 1011-1022
Published online on: 22 January 2018

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Article Open Access

NEK2 promotes hepatocellular carcinoma migration and invasion through modulation of the epithelial-mesenchymal transition

Yi Zhang, Wei Wang, Yifei Wang, Xiaohui Huang, Zhaohui Zhang, Bin Chen, Wenxuan Xie, Shaoqiang Li, Shunli Shen, Baogang Peng
Pages: 1023-1033
Published online on: 22 January 2018

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Article Open Access

Goserelin promotes the apoptosis of epithelial ovarian cancer cells by upregulating forkhead box O1 through the PI3K/AKT signaling pathway Corrigendum in /10.3892/or.2025.8910

Ning Zhang, Junjun Qiu, Tingting Zheng, Xiaodan Zhang, Keqin Hua, Ying Zhang
Pages: 1034-1042
Published online on: 15 December 2017

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Article Open Access

Characterization of different osteoclast phenotypes in the progression of bone invasion by oral squamous cell carcinoma

Jingjing Quan, Yuluan Hou, Weiling Long, Shu Ye, Zhiyuan Wang
Pages: 1043-1051
Published online on: 19 December 2017

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Article Open Access

Paeoniflorin exerts antitumor effects by inactivating S phase kinase-associated protein 2 in glioma cells

Jia Ouyang, Hui Xu, Ming Li, Xingliang Dai, Fengqing Fu, Xueguang Zhang, Qing Lan
Pages: 1052-1062
Published online on: 28 December 2017

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Article Open Access

Antitumor activity of Notch‑1 inhibition in human colorectal carcinoma cells

Wangdi Liao, Guohua Li, Yu You, Hongping Wan, Qiong Wu, Chongwen Wang, Nonghua Lv
Pages: 1063-1071
Published online on: 29 December 2017

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Article Open Access

HIF‑1α‑induced upregulation of lncRNA UCA1 promotes cell growth in osteosarcoma by inactivating the PTEN/AKT signaling pathway

Tengfei Li, Yang Xiao, Tunsheng Huang
Pages: 1072-1080
Published online on: 03 January 2018

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Article Open Access

Combination of gemcitabine and erlotinib inhibits recurrent pancreatic cancer growth in mice via the JAK-STAT pathway

Liwen Chen, Ding'an Zhou, Zhehao Liu, Xinhao Huang, Qianfan Liu, Yiping Kang, Zili Chen, Yuntao Guo, Haitao Zhu, Chengyi Sun
Pages: 1081-1089
Published online on: 08 January 2018

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Article Open Access

miR‑873 inhibits colorectal cancer cell proliferation by targeting TRAF5 and TAB1

Hui Gong, Lishan Fang, Yifan Li, Jihui Du, Bei Zhou, Xiu Wang, Hekai Zhou, Lingli Gao, Kaixin Wang, Juan Zhang
Pages: 1090-1098
Published online on: 08 January 2018

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Article Open Access

Detection of high-grade neoplasia in air-dried cervical PAP smears by a microRNA-based classifier

Mikhail K. Ivanov, Sergei E. Titov, Sergei A. Glushkov, Victoria V. Dzyubenko, Anastasia V. Malek, Polina A. Arkhangelskaya, Roman B. Samsonov, Andrey A. Mikhetko, Elena V. Bakhidze, Igor V. Berlev, Nikolay N. Kolesnikov
Pages: 1099-1111
Published online on: 12 January 2018

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Article Open Access

Fra‑1 enhances the radioresistance of colon cancer cells to X‑ray or C‑ion radiation

Satoshi Endo, Mayumi Fujita, Shigeru Yamada, Kaori Imadome, Fumiaki Nakayama, Tetsuro Isozaki, Takeshi Yasuda, Takashi Imai, Hisahiro Matsubara
Pages: 1112-1118
Published online on: 19 January 2018

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Article

Heat shock protein 27 knockdown using nucleotide‑based therapies enhances sensitivity to 5-FU chemotherapy in SW480 human colon cancer cells

Takehiro Shimada, Masashi Tsuruta, Hirotoshi Hasegawa, Koji Okabayashi, Kohei Shigeta, Takashi Ishida, Yusuke Asada, Hirofumi Suzumura, Kaoru Koishikawa, Shingo Akimoto, Yuko Kitagawa
Pages: 1119-1124
Published online on: 03 January 2018

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Article

Immune response-associated gene profiling in Japanese melanoma patients using multi-omics analysis

Yasuto Akiyama, Yoshio Kiyohara, Shusuke Yoshikawa, Masaki Otsuka, Ryota Kondou, Chizu Nonomura, Haruo Miyata, Akira Iizuka, Tadashi Ashizawa, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima, Masatoshi Kusuhara, Takashi Sugino, Ken Yamaguchi
Pages: 1125-1131
Published online on: 21 December 2017

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Article

Long non-coding RNA MEG3 functions as a tumour suppressor and has prognostic predictive value in human pancreatic cancer

Ling Ma, Feng Wang, Chong Du, Zhengkui Zhang, Huahu Guo, Xuehai Xie, Hongqiao Gao, Yan Zhuang, Marko Kornmann, Hong Gao, Xiaodong Tian, Yinmo Yang
Pages: 1132-1140
Published online on: 02 January 2018

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Article

Rhus verniciflua Stokes extract induces inhibition of cell growth and apoptosis in human chronic myelogenous leukemia K562 cells

Kyung-Wook Lee, Eun-Sik Um, Bo-Bae Jung, Eun-Sol Choi, Eun-Young Kim, Seungbo Lee, Eungyeong Jang, Jang-Hoon Lee, Youngchul Kim
Pages: 1141-1147
Published online on: 03 January 2018

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Article

Inhibition of Gli leads to antitumor growth and enhancement of cisplatin-induced cytotoxicity in large cell neuroendocrine carcinoma of the lung

Tsukasa Ishiwata, Shunichiro Iwasawa, Takahiro Ebata, Mengmeng Fan, Yuji Tada, Koichiro Tatsumi, Yuichi Takiguchi
Pages: 1148-1154
Published online on: 03 January 2018

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Article

Overexpression of interleukin-32α promotes invasion by modulating VEGF in hepatocellular carcinoma

Wen-Bo Zhao, Quan-Li Wang, Yan-Tian Xu, Shi-Feng Xu, Yang Qiu, Feng Zhu
Pages: 1155-1162
Published online on: 19 December 2017

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Article

α-solanine enhances the chemosensitivity of esophageal cancer cells by inducing microRNA‑138 expression

Jianbo Wu, Li Wang, Xinhui Du, Qianqian Sun, Yuanyuan Wang, Min Li, Wenqiao Zang, Kangdong Liu, Guoqiang Zhao
Pages: 1163-1172
Published online on: 04 January 2018

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Article

Function of miR‑152 as tumor suppressor in oral squamous cell carcinoma cells by targeting c‑MET Retraction in /10.3892/or.2022.8254

Minghe Li, Zhihong Li, Xue Wang, Yumei Wang, Cong Zhao, Lei Wang
Pages: 1173-1180
Published online on: 15 December 2017

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Article

Licochalcone A suppresses hexokinase 2-mediated tumor glycolysis in gastric cancer via downregulation of the Akt signaling pathway

Jian Wu, Xingxing Zhang, Yaohui Wang, Qingmin Sun, Min Chen, Shenlin Liu, Xi Zou
Pages: 1181-1190
Published online on: 14 December 2017

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Article

Inhibition effect of triptolide on human epithelial ovarian cancer via adjusting cellular immunity and angiogenesis

Hui Hu, Genhua Huang, Haibin Wang, Xiaoli Li, Xiaobing Wang, Ying Feng, Buzhen Tan, Tingtao Chen
Pages: 1191-1196
Published online on: 15 December 2017

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Article

Construction and investigation of lncRNA-associated ceRNA regulatory network in papillary thyroid cancer

Yangjing Zhao, Hui Wang, Chengjiang Wu, Meina Yan, Haojie Wu, Jingzhe Wang, Xinxin Yang, Qixiang Shao
Pages: 1197-1206
Published online on: 10 January 2018

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Article

MicroRNA-let-7a regulates cell autophagy by targeting Rictor in gastric cancer cell lines MGC-803 and SGC-7901

Hao Fan, Mingkun Jiang, Bowen Li, Yu He, Chi Huang, Dakui Luo, Hao Xu, Li Yang, Jundong Zhou
Pages: 1207-1214
Published online on: 05 January 2018

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Article

Synthesis and application of 131I-fulvestrant as a targeted radiation drug for endocrine therapy in human breast cancer

Guobing Yin, Bin Zeng, Zhiping Peng, Ying Liu, Lu Sun, Changan Liu
Pages: 1215-1226
Published online on: 11 January 2018

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Article

Over-regulation of microRNA-133b inhibits cell proliferation of cisplatin-induced non-small cell lung cancer cells through PI3K/Akt and JAK2/STAT3 signaling pathway by targeting EGFR

Bin Li, Cui-Min Ding, Yan-Xiao Li, Jing-Cui Peng, Nan Geng, Wen-Wen Qin
Pages: 1227-1234
Published online on: 15 January 2018

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Article

MicroRNA‑16/VEGFR2/p38/NF‑κB signaling pathway regulates cell growth of human pituitary neoplasms

Bin Lu, Ge-Ling Liu, Fang Yu, Wei-Juan Li, Xiu-Xiu Xiang, Hong-Zhen Xiao
Pages: 1235-1244
Published online on: 22 January 2018

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Article

Targeting bladder cancer using activated T cells armed with bispecific antibodies

Juan Ma, Jing Ge, Xin Xue, Weigang Xiu, Pan Ma, Ximing Sun, Man Zhang
Pages: 1245-1252
Published online on: 11 January 2018

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Article

A 60 kDa prolactin variant secreted by cervical cancer cells modulates apoptosis and cytokine production

Adrián Ramírez De Arellano, Annie Riera Leal, Edgar I. Lopez-Pulido, Luis Renee González-Lucano, José Macías Barragan, Susana Del Toro Arreola, Mariel García-Chagollan, Claudia A. Palafox-Sánchez, José F. Muñoz-Valle, Ana Laura Pereira-Suárez
Pages: 1253-1260
Published online on: 19 January 2018

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Article

The role of aldehyde dehydrogenase 1A1 in B-cell non-Hodgkin's lymphoma

Ying-Hui Song, Mei-Zuo Zhong, Qin Chai, Kui-Yu Gong, Xiao-Lang Tan, Jin-Yue Hu, Gui-Hua Wang
Pages: 1261-1268
Published online on: 18 January 2018

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Article

Knockdown of immature colon carcinoma transcript 1 induces suppression of proliferation, S-phase arrest and apoptosis in leukemia cells

Guang-Yao Li, Ji-Zhu Liu, Li Zhang, Guo-Zhen Liu, Shuang-Jing Li, Tai-Wu Xiao, Jing-Xia Wang, Le-Xin Wang, Ming Hou
Pages: 1269-1275
Published online on: 03 January 2018

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Article

Mitochondrial pyruvate carrier modulates the epithelial-mesenchymal transition in cholangiocarcinoma

Tomofumi Ohashi, Hidetoshi Eguchi, Koichi Kawamoto, Masamitsu Konno, Ayumu Asai, Hugh Colvin, Yuji Ueda, Hirofumi Takaoka, Yoshifumi Iwagami, Daisaku Yamada, Tadafumi Asaoka, Takehiro Noda, Hiroshi Wada, Kunihito Gotoh, Shogo Kobayashi, Jun Koseki, Taroh Satoh, Kazuhiko Ogawa, Yuichiro Doki, Masaki Mori, Hideshi Ishii
Pages: 1276-1282
Published online on: 20 December 2017

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Article

GC7 enhances cisplatin sensitivity via STAT3 signaling pathway inhibition and eIF5A2 inactivation in mesenchymal phenotype oral cancer cells

Liang Fang, Li Gao, Lei Xie, Guizhou Xiao
Pages: 1283-1291
Published online on: 15 December 2017

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Article

Additive antitumour effect of D‑allose in combination with cisplatin in non-small cell lung cancer cells

Nobuhiro Kanaji, Kazuyo Kamitori, Akram Hossain, Chisato Noguchi, Ayako Katagi, Norimitsu Kadowaki, Masaaki Tokuda
Pages: 1292-1298
Published online on: 04 January 2018

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Article

Peiminine serves as an adriamycin chemosensitizer in gastric cancer by modulating the EGFR/FAK pathway

Qianqian Tang, Yunfei Wang, Lanjing Ma, Meiling Ding, Tingyu Li, Yongzhan Nie, Zhengyi Gu
Pages: 1299-1305
Published online on: 03 January 2018

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Article

Effects of epidermal growth factor receptor fusion protein on the cytotoxic activity of SOCS1-silenced dendritic cells in vitro

Qichuan Jiang, Xuefeng Wang, Ming Qian, Dong Chen, Yanan Xu
Pages: 1306-1312
Published online on: 15 December 2017

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Article

Estrogen receptor β1 activation accelerates resistance to epidermal growth factor receptor-tyrosine kinase inhibitors in non-small cell lung cancer

Shengling Fu, Changyu Liu, Quanfu Huang, Sheng Fan, Hexiao Tang, Xiangning Fu, Bo Ai, Yongde Liao, Qian Chu
Pages: 1313-1321
Published online on: 04 January 2018

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Article

CHK1 inhibition sensitizes pancreatic cancer cells to gemcitabine via promoting CDK-dependent DNA damage and ribonucleotide reductase downregulation

Min Liang, Tiangang Zhao, Linfeng Ma, Yingjie Guo
Pages: 1322-1330
Published online on: 20 December 2017

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Article

2-Phenyl-4-quinolone (YT-1) induces G2/M phase arrest and an intrinsic apoptotic mechanism in human leukemia cells

Meng‑Wei Lin, Jai‑Sing Yang, Chi‑Cheng Lu, Chingju Lin, Sheng‑Chu Kuo, Fuu‑Jen Tsai, Miau‑Rong Lee
Pages: 1331-1337
Published online on: 20 December 2017

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Article

Serum microRNA panel excavated by machine learning as a potential biomarker for the detection of gastric cancer

Yao Huang, Jie Zhu, Wenshuai Li, Ziqiang Zhang, Panpan Xiong, Hong Wang, Jun Zhang
Pages: 1338-1346
Published online on: 19 December 2017

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Article

Galectin-1 expression in activated pancreatic satellite cells promotes fibrosis in chronic pancreatitis/pancreatic cancer via the TGF-β1/Smad pathway

Dong Tang, Qi Wu, Jingqiu Zhang, Hongpeng Zhang, Zhongxu Yuan, Jiaming Xu, Yang Chong, Yuqin Huang, Qingquan Xiong, Sen Wang, Ying Tian, Yongdie Lu, Xiao Ge, Wenjing Shen, Daorong Wang
Pages: 1347-1355
Published online on: 09 January 2018

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Article

Epithelial mesenchymal transition induced by the CXCL9/CXCR3 axis through AKT activation promotes invasion and metastasis in tongue squamous cell carcinoma Corrigendum in /10.3892/or.2020.7883

Ziliang Li, Jianqi Liu, Lei Li, Shuai Shao, Jianhua Wu, Li Bian, Yongwen He
Pages: 1356-1368
Published online on: 20 December 2017

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Article

Targeting the overexpressed CREB inhibits esophageal squamous cell carcinoma cell growth

Ping Chen, Miaomiao Li, Qianyun Hao, Xuesong Zhao, Tao Hu
Pages: 1369-1377
Published online on: 19 December 2017

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Article

Terrein inhibits migration of human breast cancer cells via inhibition of the Rho and Rac signaling pathways

Anongnard Kasorn, Fabien Loison, Thaned Kangsamaksin, Suchada Jongrungruangchok, Mathurose Ponglikitmongkol
Pages: 1378-1386
Published online on: 04 January 2018

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Article

Acylated and unacylated ghrelin inhibit apoptosis in myoblasts cocultured with colon carcinoma cells

Xianliang Zeng, Sizeng Chen, Yanfeng Lin, Zhao Ke
Pages: 1387-1395
Published online on: 12 January 2018

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Article

Antibody-nanoparticle conjugate constructed with trastuzumab and nanoparticle albumin-bound paclitaxel for targeted therapy of human epidermal growth factor receptor 2-positive gastric cancer

Jian Xiong, Shuhua Han, Shuang Ding, Jingchao He, Haijun Zhang
Pages: 1396-1404
Published online on: 09 January 2018

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Article

Sigma-1 receptor (σ1R) is downregulated in hepatic malignant tumors and regulates HepG2 cell proliferation, migration and apoptosis

Qingxia Xu, Liang Li, Cuihong Han, Li Wei, Lingling Kong, Fanzhong Lin
Pages: 1405-1413
Published online on: 22 January 2018

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Article

Aspirin and metformin exhibit antitumor activity in murine breast cancer

Maoyuan Zhao, Yuyi Wang, Chi Du, Yanyang Liu, Nan Zhang, Feng Luo
Pages: 1414-1422
Published online on: 04 January 2018

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Article

TTF1‑NP induces protective autophagy during apoptosis by inhibiting the Akt/mTOR pathway and activating JNK in human liver cancer cells

Xuan Zhang, Meilan Zhang, Bin Xiao, Wenjun Jiao, Silin Zhang, Xuewu Zhang
Pages: 1423-1431
Published online on: 05 January 2018

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Article

Expression and prognostic significance of TRPV6 in the development and progression of pancreatic cancer Corrigendum in /10.3892/or.2022.8395

He Song, Ming Dong, Jianping Zhou, Weiwei Sheng, Xin Li, Wei Gao
Pages: 1432-1440
Published online on: 15 January 2018

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Article

CLDN5 affects lncRNAs acting as ceRNA dynamics contributing to regulating blood‑brain barrier permeability in tumor brain metastasis

Shun‑Chang Ma, Qi Li, Jia‑Yi Peng, Jian‑Long Zhouwen, Dai‑Nan Zhang, Chuan‑Bao Zhang, Wen‑Guo Jiang, Wang Jia
Pages: 1441-1453
Published online on: 10 January 2018

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Article

miR-141 inhibits prostatic cancer cell proliferation and migration, and induces cell apoptosis via targeting of RUNX1 Retraction in /10.3892/or.2023.8679

Song Xu, Jingping Ge, Zhengyu Zhang, Wenquan Zhou
Pages: 1454-1460
Published online on: 11 January 2018

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Article

miR-375 inhibits IFN-γ-induced programmed death 1 ligand 1 surface expression in head and neck squamous cell carcinoma cells by blocking JAK2/STAT1 signaling

Qingwei Wu, Yingying Zhao, Yiyuan Sun, Xiaojun Yan, Peihua Wang
Pages: 1461-1468
Published online on: 02 January 2018

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Article

Polysaccharide sulphated derivative from Aconitum coreanum induces cell apoptosis in the human brain glioblastoma U87MG cell line via the NF-κB/Bcl-2 cell apoptotic signaling pathway

Libo Sun, Zhijun Wang, Hailiang Wang, Jincheng Li, Huaxin Liang
Pages: 1469-1474
Published online on: 19 December 2017

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Article

Cytisine induces endoplasmic reticulum stress caused by calcium overload in HepG2 cells

Lei Yu, Bo Jiang, Zhifeng Chen, Xin Wang, Dongxue Shang, Xiaopo Zhang, Yongxue Sun, Jinghui Yang, Yubin Ji
Pages: 1475-1484
Published online on: 08 January 2018

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Article

Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E‑BP1 in nasopharyngeal carcinoma cells

Yudui Xia, Xia Liu, Chunlin Zou, Shixiu Feng, Hongwei Guo, Yeguo Yang, Yong Lei, Jian Zhang, Yi Lu
Pages: 1485-1493
Published online on: 16 January 2018

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Article

MicroRNA-454 inhibits the malignant biological behaviours of gastric cancer cells by directly targeting mitogen-activated protein kinase 1 Retraction in /10.3892/or.2022.8276

Xiaodong Wang, Baichun Liu, Fuxing Wen, Ying Song
Pages: 1494-1504
Published online on: 20 December 2017

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Article

Serum and glucocorticoid-regulated kinase 1 (SGK1) is a predictor of poor prognosis in non-small cell lung cancer, and its dynamic pattern following treatment with SGK1 inhibitor and γ-ray irradiation was elucidated

Zhiyuan Tang, Qin Shen, Hao Xie, Zhu Zhou, Guanglin Shi, Caixin Zhang, Anaz Mohammed, Yi Wu, Songshi Ni, Xiaoyu Zhou
Pages: 1505-1515
Published online on: 03 January 2018

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Article

Fucoidan downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells

In-Hye Kim, Taek-Jeong Nam
Pages: 1516-1522
Published online on: 04 January 2018

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Article

Antitumor activity of curcumin by modulation of apoptosis and autophagy in human lung cancer A549 cells through inhibiting PI3K/Akt/mTOR pathway

Furong Liu, Song Gao, Yuxuan Yang, Xiaodan Zhao, Yameng Fan, Wenxia Ma, Danrong Yang, Aimin Yang, Yan Yu
Pages: 1523-1531
Published online on: 04 January 2018

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Article

MicroRNA-125 modulates radioresistance through targeting p21 in cervical cancer

Abraham Pedroza‑Torres, Alma D. Campos‑Parra, Oliver Millan‑Catalan, Yahir A. Loissell‑Baltazar, Horacio Zamudio‑Meza, David Cantú de León, Gonzalo Montalvo‑Esquivel, David Isla‑Ortiz, Luis A. Herrera, Óscar Ángeles‑Zaragoza, Guadalupe Robelo‑Romero, Ángel Herrera‑Gómez, Carlos Pérez‑Plasencia
Pages: 1532-1540
Published online on: 18 January 2018

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Journal Cover
January-2026 Volume 55 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Article Open Access

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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Article Open Access

S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Review Open Access

Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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Review Open Access

The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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Review Open Access

From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Review Open Access

Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Article Open Access

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Alternative splicing in cancer drug resistance: Mechanisms and therapeutic prospects (Review)

Wenpu Zhu, Zikun Wu, Chai Luv, Banghe Bao, Weijie Zhao, Guanglong Chen, Hang Yang, Huihan Ai, Faqiang Liu, Zhi Li
Article Number: 31
Published online on: 05 December 2025

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Article Open Access

Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Review

Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Article Open Access

Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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