miR‑124 targets retinoid X receptor α to reduce growth of TSC2‑deficient lymphangioleiomyomatosis

  • Authors:
    • Jia Liu
    • Jun Yuan
    • Tianxiang Feng
    • Yinjuan Zhao
    • Qian Sun
    • Jun Chen
    • Jingyu Chen
    • Meiling Jin
    • Bin Xue
  • View Affiliations

  • Published online on: December 7, 2018     https://doi.org/10.3892/or.2018.6916
  • Pages: 1342-1350
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Abstract

Lymphangioleiomyomatosis (LAM) is a rare neoplastic disease that leads to progressive destruction of lung function. However, the mechanisms underlying the progression of LAM remain unknown. Recent studies demonstrated that miR‑124‑3p (hereinafter referred to as miR‑124) is a downregulated miRNA in tumors and it is still unclear whether miR‑124 participates in LAM. In the present study, it was revealed that miR‑124 was downregulated in LAM specimens and overexpression of miR‑124 resulted in the apoptosis of TSC2‑deficient cells via RXRα (retinoid X receptor α), while slightly influencing TSC2 wild‑type cells. Furthermore, a xenograft model demonstrated that the miR‑124/RXRα axis regulated the growth and fatty acid oxidation genes in TSC2‑null cells. Altogether, our results revealed the suppressive functions and mechanisms of miR‑124 in LAM progression, providing novel therapeutic targets for LAM treatment.

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February 2019
Volume 41 Issue 2

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Copy and paste a formatted citation
APA
Liu, J., Yuan, J., Feng, T., Zhao, Y., Sun, Q., Chen, J. ... Xue, B. (2019). miR‑124 targets retinoid X receptor α to reduce growth of TSC2‑deficient lymphangioleiomyomatosis. Oncology Reports, 41, 1342-1350. https://doi.org/10.3892/or.2018.6916
MLA
Liu, J., Yuan, J., Feng, T., Zhao, Y., Sun, Q., Chen, J., Chen, J., Jin, M., Xue, B."miR‑124 targets retinoid X receptor α to reduce growth of TSC2‑deficient lymphangioleiomyomatosis". Oncology Reports 41.2 (2019): 1342-1350.
Chicago
Liu, J., Yuan, J., Feng, T., Zhao, Y., Sun, Q., Chen, J., Chen, J., Jin, M., Xue, B."miR‑124 targets retinoid X receptor α to reduce growth of TSC2‑deficient lymphangioleiomyomatosis". Oncology Reports 41, no. 2 (2019): 1342-1350. https://doi.org/10.3892/or.2018.6916